摘要:
Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
摘要翻译:淀粉样蛋白结合它们是含有Chrysamine的G衍生物,药物组合物的化合物,并且使用搜索的化合物的方法,以确定体内阿尔茨海默氏脑和诊断淀粉样变性,:如唐氏综合征,其特征等病理状态下进行说明。 使用搜索的组合物,以防止在淀粉样变性相关的病症细胞变性和淀粉样诱导的毒性含Chrysamine G和它们的衍生物的药物组合物和方法,以便说明。 因此利用Chrysamine G ^衍生物染色或检测活检或死后组织淀粉样蛋白沉积物的方法被描述。 因此利用Chrysamine G ^衍生物量化活检和死后组织匀浆中淀粉样蛋白沉积物的方法被描述。
摘要:
Azo compounds of formula (I), wherein X stands for halogen, in particular for chlorine, or C1-C4alkoxy, in particular for methoxy, Y stands for -CH2- or -O-, R1 and R2, independently from each other, stand for hydrogen, C1-C8alkyl, or C6-C14aryl, which may be substituted up to three times with C1-C8alkyl, C1-C4alkoxy or halogen, a process for their preparation and their use as fluorescent compounds, in particular as solid fluorescent compounds, such as for special effect printing, security printing or in the opto-electronic field.
摘要:
A fluidizing agent which is a diamine and/or diquaternary ammonium salt of a coloured acid of the phthalocyanine or disazo series of dyestuffs wherein the diamine or diquaternary ammonium cation is of formula (1) wherein R is optionally substituted C6-30-alkyl or optionally substituted C6-30-alkenyl; R is hydrogen, optionally substituted C1-30-alkyl or C2-30-alkenyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; R , R and R are each, individually, optionally substituted C1-6-alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; R is hydrogen, optionally substituted C1-6-alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; X is C1-12-alkylene or C2-14-alkenylene; or R and R together with the two nitrogen atoms to which they are attached and X form a ring; and/or R and R together with the nitrogen atom to which they are attached form a ring. Preferably, R is C14-18-alkyl, X is propylene and R to R is methyl.
摘要:
Verfahren zum Herstellen von Monoazo- oder Disazo- pigmenten, dadurch gekennzeichnet, dass man a) zu einer Lösung eines Diazonium- und/oder Tetrazoniumsalzes eines aromatischen oder heterocyclischen Amins eine Lösung oder Suspension enthaltend 0,1-50 Gew.% des theoretisch einzusetzenden Gesamtgewichts einer oder mehrerer Kupplungskomponenten zugibt, und b) die Kupplungsreaktion durch Beimischen des gemäss Verfahrensschritt a) erhaltenen teilweise gekuppelten Produkts zu einer Lösung oder Suspension einer oder mehrerer im Verfahrensschritt a) eingesetzten oder davon verschiedenen Kupplungskomponente vervollständigt. Die so hergestellten Pigment zeigen verglichen mit nach herkömmlichen Methoden hergestellten Produkten erhöhte Farbstärke, verbesserte Transparenz, verbesserte Fliesseigenschaften, erhöhte Reinheit und Dispergierbarkeit.
摘要:
A process for the preparation of disazo pigments by which coupling can be attained in an enhanced conversion; and disazo pigments prepared by this process and excellent in transparency, sharpness, staining power and gloss. This process is characterized by continuously pouring an aqueous solution containing a coupler component of the general formula (I) and an aqueous solution of a tetrazo component derived from a benzidine into an aqueous acid solution put in a batch-wise agitated tank at a mole ratio of the coupler to the tetrazo component of 2 : 0.8 to 0.99 to conduct coupling: formula (I), wherein X, Y and Z are each independently H, CH3, OCH3 or C1.
摘要:
Diarylide pigment compositions useful for preparing storage stable printing inks (especially of the publication gravure type) are prepared using a poly (alkylene oxide) substituted acetoacetanilide together with a typical acetoacetanilide and coupling the mixture of acetanilides with tetrazotized dichlorobenzidine.
摘要:
An object that is to be achieved by the present invention is to provide an azo pigment having excellent transparency, suitable dispersibility, and a low viscosity, an ink, and the like. An azo pigment according to the present invention has a zeta potential of -80 to -30 mV in isopropanol (IPA). The content of a metal element in the azo pigment is preferably 0.05 to 2.00 parts by mass relative to 100 parts by mass of the azo pigment. The metal element is preferably an iron element. The ratio (Fe/C) of the concentration Fe (atomic%) of an iron element in the surfaces of particles of the azo pigment to the concentration C (atomic%) of a carbon element in the surfaces of the particles of the azo pigment which are determined by X-ray photoelectron spectroscopy is preferably 0.20 or less.