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公开(公告)号：EP4457239A2
公开(公告)日：2024-11-06
申请号：EP23743886.6
申请日：2023-01-18
申请人： Nkarta, Inc.
发明人： TRAGER, James, Barnaby , CHAN, Ivan , WANG, Don-Hong , LI, Guangnan , LAZETIC, Alexandra, Leida, Liana , GUO, Chao
IPC分类号： C07K14/725 , C07K14/15 , C07K19/00 , C12N5/0783 , C07K16/30 , A61P35/00
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2.发明公开
公开(公告)号：EP4456912A1
公开(公告)日：2024-11-06
申请号：EP22856960.4
申请日：2022-12-27
发明人： CARTON, Jill, Marinari , WHEELER, John , DOWER, Christopher , UCHUROVA, Raisa , MILLER, Michael , NISHIMURA, Toshinobu , SANTOSTEFANO, Katherine , WALLET, Mark
IPC分类号： A61K39/00 , C12N5/074 , C12N5/0783 , C12N5/0789 , C07K14/725 , C07K16/30
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公开(公告)号：EP4271702B1
公开(公告)日：2024-11-06
申请号：EP21854871.7
申请日：2021-12-28
发明人： FARKAS, Sándor , TAKÁCS, Zoltán , NACSA, János , RÁCZ, Gábor , HORNYÁK, Péter , HUJBER, Zoltán , CIOCA, Daniel
IPC分类号： C07K14/435 , A61K47/64 , C12N15/62 , A61K39/00 , A61K47/65 , A61K49/00 , C12N5/0783 , G01N33/532 , G01N33/574
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公开(公告)号：EP4110799B1
公开(公告)日：2024-11-06
申请号：EP21713843.7
申请日：2021-03-01
IPC分类号： A61K39/00 , C12N5/0783 , A61K35/13 , A61K38/00 , C07K14/54 , A61K35/17 , C07K14/55 , C07K14/705 , C07K14/725 , C07K14/73 , C07K16/28
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公开(公告)号：EP4420663A3
公开(公告)日：2024-10-30
申请号：EP24173692.5
申请日：2014-12-19
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： C07K19/00 , C12N5/0783 , A61K31/436 , A61K35/17 , C07K14/725 , C07K16/28
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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公开(公告)号：EP4448728A2
公开(公告)日：2024-10-23
申请号：EP22844462.6
申请日：2022-12-16
申请人： VIB VZW , Universiteit Gent
IPC分类号： C12N5/0783 , C07K14/725 , A61P35/00 , A61K39/00 , C07K16/28
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公开(公告)号：EP4428229A1
公开(公告)日：2024-09-11
申请号：EP22889998.5
申请日：2022-11-02
发明人： KISHIMOTO, Megumi , SHIMIZU, Yuto , KUBOTA, Susumu , YAGYU, Shigeki , SUEMATSU, Masaya , NAKAZAWA, Yozo , TANAKA, Miyuki
IPC分类号： C12N5/0783 , C12N15/11
摘要： The present invention provides a method for producing a chimeric antigen receptor T (CAR-T) cell, including a step of bead separating with a specific factor a T cell from a T cell source, wherein the specific factor is CD45RA+ or the like. The method enables production of CAR-T cells high antitumor property, and can produce highly functional CAR-T cells conveniently in a short time at a low cost.
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8.发明公开
公开(公告)号：EP4426722A1
公开(公告)日：2024-09-11
申请号：EP22891024.6
申请日：2022-11-02
发明人： MESHINCHI, Soheil , LE, Quy , RIES, Rhonda , CASTRO, Sommer
IPC分类号： C07K14/705 , A61K35/17 , A61K47/64 , A61P35/02 , C12N5/0783 , C12N5/10 , C12N15/85
CPC分类号： A61P35/02 , C07K14/7051 , C07K16/28 , A61K39/464402 , A61K39/4611 , C07K14/70521 , C12N15/62 , C07K2317/62220130101 , C07K2319/0320130101 , C07K2319/3320130101 , C07K2317/5320130101 , C07K2317/2420130101 , C12N2740/1604320130101 , C12N5/0636 , C12N2510/0020130101 , A61K39/4631 , A61K2239/1320230501 , A61K2239/1720230501 , A61K2239/4820230501 , A61K45/06 , A61K31/7034 , A61K31/704 , A61K31/475 , A61K31/167
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公开(公告)号：EP4426319A1
公开(公告)日：2024-09-11
申请号：EP22813969.7
申请日：2022-11-04
申请人： APHP (Assistance Publique - Hôpitaux de Paris) , INSERM (Institut National de la Santé et de la Recherche Médicale) , Fondation Imagine - Institut des Maladies Génétiques , Université Paris Cité
IPC分类号： A61K35/17 , C12N5/0783
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公开(公告)号：EP4176048B1
公开(公告)日：2024-09-11
申请号：EP21787042.7
申请日：2021-09-23
IPC分类号： A61K39/00 , C12N5/0783 , A61K35/17 , A61K38/00 , C12N15/113 , C12N15/90 , A61K48/00
CPC分类号： C12N5/0636 , C12N2510/0020130101 , C12N2310/2020170501 , C12N15/1138 , C12N2310/31520130101 , A61K38/00 , C12N15/907 , C12N2750/1414320130101 , A61K48/00 , A61K39/4611 , A61K39/4631 , A61K39/464438 , A61K39/464417 , A61K39/464412 , A61K2239/2620230501 , A61K2239/4820230501 , A61K2239/3820230501 , A61K2239/5420230501 , A61K2239/5620230501 , A61K2239/3120230501 , A61K39/464462
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