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公开(公告)号：EP4420663A3
公开(公告)日：2024-10-30
申请号：EP24173692.5
申请日：2014-12-19
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： C07K19/00 , C12N5/0783 , A61K31/436 , A61K35/17 , C07K14/725 , C07K16/28
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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公开(公告)号：EP3331913A1
公开(公告)日：2018-06-13
申请号：EP16754055.8
申请日：2016-08-05
发明人： LOEW, Andreas , GRANDA, Brian , RAMONES, Melissa
IPC分类号： C07K16/28 , C07K16/30 , C07K14/725 , C07K14/705
CPC分类号： C07K14/7051 , C07K16/2803 , C07K16/30 , C07K19/00 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C07K2319/70
摘要： The present disclosure features the use of chimeric CD3 proteins to modulate T cell Receptor (TCR) signaling. Specifically, the disclosure is based, in part, on the discovery that chimeric CD3 proteins (e.g., CD3delta, CD3gamma, and CD3epsilon) having all or most of their extracellular domain fused to an antigen binding domain can activate the TCR in the presence of a cognate antigen. The disclosure is further based on the observation that the above chimeric proteins can be potentiated through the inclusion of a co-stimulatory domain in the intracellular portion of the chimeric molecule. Thus, the preferred elements of the engineered signaling complexes of the disclosure include an antigen binding domain, an extracellular domain derived from one of the above CD3 proteins, and an intracellular co-stimulatory domain.
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公开(公告)号：EP3523331A1
公开(公告)日：2019-08-14
申请号：EP17797204.9
申请日：2017-10-06
发明人： BRANNETTI, Barbara , BROGDON, Jennifer , ENGELS, Boris , GRANDA, Brian , HUANG, Lu , LEI, Ming , LI, Na , ZHANG, Jimin , GUIMARAES, Carla
IPC分类号： C07K16/28 , A61K39/395
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公开(公告)号：EP4420663A2
公开(公告)日：2024-08-28
申请号：EP24173692.5
申请日：2014-12-19
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： A61K31/436
CPC分类号： C07K14/7051 , C07K14/70521 , C07K14/70539 , C07K14/70578 , C12N9/90 , C07K2319/0020130101 , C07K2319/0320130101 , C07K2319/7020130101 , C12N9/1205 , C07K2319/4120130101 , C07K2319/4320130101 , A61K31/436 , C12Y502/00 , A61P35/00 , A61P37/04 , A61K39/464468 , A61K2239/2420230501 , A61K2239/4820230501 , A61K39/4631 , A61K39/464404 , A61K2239/2320230501 , A61K39/4611 , A61K2239/3820230501 , A61K39/464412
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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5.发明公开
公开(公告)号：EP3615055A1
公开(公告)日：2020-03-04
申请号：EP18727094.7
申请日：2018-04-27
IPC分类号： A61K38/17 , A61K35/17 , C07K14/725 , C07K16/28 , C12N5/0783
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公开(公告)号：EP3087101A1
公开(公告)日：2016-11-02
申请号：EP14872734.0
申请日：2014-12-19
申请人： Novartis AG , The Trustees of The University of Pennsylvania , Brogdon, Jennifer , Engels, Boris , GLASS, David, Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , Milone, Michael C. , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS,William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： C07K19/00 , C12N5/0783
CPC分类号： C07K16/2863 , A61K31/436 , A61K35/17 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K14/71 , C07K2317/622 , C07K2319/00 , C07K2319/03 , C07K2319/41 , C07K2319/43 , C07K2319/70 , C12N9/1205 , C12N9/90 , C12Y502/00
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
摘要翻译： 提供了与可调节嵌合抗原受体（RCAR）相关的组合物和方法，其中可以控制RCAR的细胞内信号传导或增殖以优化使用表达RCAR的细胞以提供免疫应答。 例如，RCAR可以包含二聚转换开关，其在存在二聚化分子时可以将细胞内信号转导域偶联到细胞外识别元件，例如抗原结合结构域，抑制性反配体结合结构域或共刺激ECD结构域 。 RCAR可以被设计成包括对所需抗原靶特异性并用于治疗疾病的合适的抗原结合结构域。
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公开(公告)号：EP3972993A1
公开(公告)日：2022-03-30
申请号：EP20731690.2
申请日：2020-05-19
申请人： Novartis AG
IPC分类号： C07K14/725 , C07K14/705 , A61P35/00
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公开(公告)号：EP3713962A1
公开(公告)日：2020-09-30
申请号：EP18880478.5
申请日：2018-11-20
申请人： Novartis AG
发明人： GRANDA, Brian , HONG, Connie , RAMONES, Melissa , SKEGRO, Darko
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公开(公告)号：EP3972998A1
公开(公告)日：2022-03-30
申请号：EP20731689.4
申请日：2020-05-19
申请人： Novartis AG
发明人： GRANDA, Brian , RAYO, Amy , HONG, Connie , CHELUR, Dattananda , LU, Haihui , CEBE, Regis , JANG, Sunyoung
IPC分类号： C07K16/28 , A61P35/00 , C07K14/705 , A61K39/395
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公开(公告)号：EP4281115A1
公开(公告)日：2023-11-29
申请号：EP22701058.4
申请日：2022-01-18
申请人： Novartis AG
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