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公开(公告)号:EP4450619A1
公开(公告)日:2024-10-23
申请号:EP22907471.1
申请日:2022-12-14
发明人: YOKOE, Sho , OCHI, Kensuke , NAKANO, Shogo , ITO, Sohei
摘要: Provided is a novel reverse transcriptase with excellent thermal stability. A reverse transcriptase comprising the following amino acid sequence: (a) an amino acid sequence having at least 75% identity with the amino acid sequence represented by SEQ ID NO: 2 or 3; or (b) an amino acid sequence having deletion, substitution, insertion, or addition of one or several amino acids in the amino acid sequence represented by SEQ ID NO: 2 or 3.
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公开(公告)号:EP4448739A2
公开(公告)日:2024-10-23
申请号:EP22908777.0
申请日:2022-12-16
发明人: ESTRIN, Eric , PALLUK, Sebastian , ARLOW, Daniel
IPC分类号: C12N9/12 , C12Q1/6844 , C12N9/16 , C12P19/34
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公开(公告)号:EP3250715B1
公开(公告)日:2024-10-23
申请号:EP16743914.0
申请日:2016-01-25
发明人: JUDICE, Stephen, A.
IPC分类号: C12Q1/68 , C07H21/04 , C12N9/16 , C12P19/34 , C07H21/00 , C12Q1/6818 , C12Q1/6823
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公开(公告)号:EP4441240A2
公开(公告)日:2024-10-09
申请号:EP22902196.9
申请日:2022-12-01
CPC分类号: C12N15/1096 , C12Q1/6855 , C12Q1/6874 , C12Q1/6806 , C12Q1/6844
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公开(公告)号:EP4430176A2
公开(公告)日:2024-09-18
申请号:EP22817897.6
申请日:2022-11-10
申请人: DNA Script
发明人: MCHALE, Daniel , DEGROTTE, Florent , JAZIRI, Faten , SUNE, Elodie , SOSKINE, Mikhael , CHAMPION, Elise
CPC分类号: C12N9/1264 , C12Y207/07031 , C12P19/34
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公开(公告)号:EP4378531A3
公开(公告)日:2024-09-04
申请号:EP24157422.7
申请日:2018-03-09
IPC分类号: C12N5/02 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/113 , C12P19/34 , C07H21/04 , C12Q1/68 , A61K31/7105 , A61K31/713 , A61K39/00 , A61P35/00 , A61K35/13
CPC分类号: A61K2039/54520130101 , A61K2039/5556120130101 , C12N2320/3220130101 , C12N15/1138 , A61K31/713 , C12N2310/1120130101 , A61P35/00 , A61K2039/58520130101 , A61K39/0011 , A61K31/7105 , A61K39/001103 , A61K2039/515220130101 , A61K35/13
摘要: The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.
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公开(公告)号:EP4419713A1
公开(公告)日:2024-08-28
申请号:EP22884322.3
申请日:2022-10-17
发明人: LACKEY, Jeremy , BANYAI, William
IPC分类号: C12Q1/6869 , C12M1/34 , C12P19/34 , C12Q1/6834 , C12Q1/6876 , C12Q1/6806
CPC分类号: C12Q1/6874 , C40B40/06
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公开(公告)号:EP4416304A1
公开(公告)日:2024-08-21
申请号:EP22881991.8
申请日:2022-10-12
申请人: Indevr, Inc.
IPC分类号: C12Q1/6841 , C12Q1/6837 , C12Q1/6816 , C12P19/34
CPC分类号: C12P19/34 , C12Q1/6837
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公开(公告)号:EP4413149A1
公开(公告)日:2024-08-14
申请号:EP22798206.3
申请日:2022-09-02
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