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127 条记录 (耗时 0.02 秒)

    COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS
    2.
    发明公开
    COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS 审中-公开
    化合物和鉴定，合成，优化和蛋白调节剂的创建方法

    公开(公告)号：EP1960535A2

    公开(公告)日：2008-08-27

    申请号：EP06838389.2

    申请日：2006-11-24

    申请人： Housey, Gerard M.

    发明人： HOUSEY, Gerard, M.

    IPC分类号： C12Q1/50

    CPC分类号： G01N33/5008 ,  G01N33/5011 ,  G01N33/502

    摘要： This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost, reductions in the drug discovery process resulting from the corresponding increases in efficiency.

    STABILISIERTES REAGENZ UND VERFAHREN ZUR BESTIMMUNG VON CREATIN-KINASE
    3.
    发明授权
    STABILISIERTES REAGENZ UND VERFAHREN ZUR BESTIMMUNG VON CREATIN-KINASE 有权
    稳定化试剂，用于确定肌酸激酶

    公开(公告)号：EP1038024B1

    公开(公告)日：2007-06-13

    申请号：EP98966274.7

    申请日：1998-12-09

    申请人： Roche Diagnostics GmbH

    发明人： NAGEL, Rolf ,  MISTELE, Jürgen ,  SCHRÖDER, Norbert

    IPC分类号： C12Q1/50

    CPC分类号： C12Q1/50

    摘要： A stabilised reagent for photometric enzymatic determination of creatine kinase (CK) in biological sample material by forming ATP from creatine phosphate and ADP and detection of the ATP thus formed containing an organic or inorganic sulphur compound, preferably with a molar deficiency in relation to the added CK activator. A corresponding reagent remains stable at 2-8 DEG C for up to 12 months without incurring any significant functional loss.

    CELL CYCLE REGULATORY FACTOR
    6.
    发明公开
    CELL CYCLE REGULATORY FACTOR 审中-公开
    细胞周期调控因子

    公开(公告)号：EP1090987A4

    公开(公告)日：2003-05-28

    申请号：EP99957181

    申请日：1999-06-23

    申请人： CHUGAI PHARMACEUTICAL CO LTD

    发明人： NAKANISHI MAKOTO

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12N15/54 ,  C12Q1/50 ,  A61K38/45 ,  C12N5/10 ,  C12Q1/48

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/4738 ,  C12Q1/50

    摘要： To search human Cds1 (hCds1) being homologous with yeast cell cycle regulatory factors scCds1 and spCds1, GenBank EST data base is retrieved based on fission yeast spCds1 sequence and baker's yeast scCds1 sequence, thereby finding a homologous molecule (dCds1) of Drosophila which is significantly homologous with spCds1 and sdCds1. Then the full-length gene thereof is isolated. It is confirmed that this gene is expressed strongly in testis and, moreover, widely expressed in other tissues. A protein encoded by the thus isolated gene is prepared as a recombinant protein and its kinase activity is detected in vitro. As a result, it is found out that this protein efficiently phosphorylates cdc25 and histone H1.

    REAGENT FOR ASSAYING CREATINE KINASE.
    7.
    发明公开
    REAGENT FOR ASSAYING CREATINE KINASE. 失效
    试剂测定肌酸激酶。

    公开(公告)号：EP0685561A4

    公开(公告)日：1998-10-07

    申请号：EP95902987

    申请日：1994-12-19

    申请人： IATRON LAB

    发明人： TSUBOTA HIROYUKI ,  SHIMADA REIKO

    IPC分类号： C12Q1/50 ,  C12Q1/32 ,  C12Q1/48 ,  C12Q1/54

    CPC分类号： C12Q1/50

    摘要： A reagent for assaying creatine kinase, which contains glucokinase or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate, creatine phosphate, oxidized nicotinamide adenine dinucleotide phosphate, magnesium salt, and glucose, and which is composed of a first liquid reagent having a pH value of 7.5 to 10 and containing at least glucokinase and/or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate and creatine phosphate, and a second liquid reagent having a pH value of 2 to 5 and containing at least oxidized nicotinamide adenine dinucleotide phosphate. This reagent can be stored in liquid form stably for long at normal or low temperatures in both dark and light places. Hence it can be used without the necessity for dissolution after being preserved for long at the site of clinical examination and is also applicable to automatic analyzers.

    Creatine kinase reagent
    9.
    发明公开
    Creatine kinase reagent 失效
    ReagenzfürKreatinkinase

    公开(公告)号：EP0721986A2

    公开(公告)日：1996-07-17

    申请号：EP96300226.6

    申请日：1996-01-11

    申请人： WAKO PURE CHEMICAL INDUSTRIES LTD

    发明人： Danno,Masakazu, c/o Osaka Kenkyusho, Wako ,  Hanada, Toshiro, c/o Osaka Kenkyusho, Wako

    IPC分类号： C12Q1/50

    CPC分类号： C12Q1/50

    摘要： A stabilized liquid reagent for measuring creatine kinase activity which comprises as the main constituent at least one compound selected from the group consisting of thioglycerol, 2-mercaptoethanol, and 2-mercaptoethanesulfonic acid or its salt is stable and can be stored for a long period of time.

    摘要翻译： 一种用于测量肌酸激酶活性的稳定液体试剂，其包含作为主要成分的至少一种选自硫代甘油，2-巯基乙醇和2-巯基乙磺酸或其盐的化合物是稳定的，并且可以长期储存 时间。