公开(公告)号：JP2013092386A

公开(公告)日：2013-05-16

申请号：JP2011232828

申请日：2011-10-24

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： DOI SHIGERU

IPC: G01N27/327 ,  G01N27/26 ,  G01N27/416

Abstract: PROBLEM TO BE SOLVED: To provide a test piece that can be loaded in a different analysis device.SOLUTION: There is provided a test piece 101 loaded in an analysis device, the test-piece including a loaded part 111 inserted into a first reception part of the analysis device, and a second loaded part 112 which is inserted into a second reception part different from the first reception part provided to the analysis device or a different analysis device.

Abstract translation: 要解决的问题：提供可以装载在不同分析装置中的试件。 提供了一种加载在分析装置中的试片101，该试件包括插入分析装置的第一接收部分中的加载部分111和插入到分析装置中的第二加载部分112 接收部分不同于提供给分析装置的第一接收部分或不同的分析装置。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013083634A

公开(公告)日：2013-05-09

申请号：JP2012194188

申请日：2012-09-04

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： HOASHI SHOGO ,  YAMAGUCHI TAKEHIRO

IPC: G01N27/327 ,  G01N27/416

CPC classification number: C12Q1/004

Abstract: PROBLEM TO BE SOLVED: To provide a glucose sensor that is capable of measuring a glucose concentration even in the case where Aspergillus oryzae type FAD-GDH and a ruthenium compound are used in combination.SOLUTION: The glucose sensor includes an insulative substrate, an electrode system having a working electrode and a counter electrode provided on the substrate, and a reagent layer provided on the electrode system. The reagent layer contains Aspergillus oryzae type FAD-GDH, a ruthenium compound, and PMS (phenazine methosulfate).

Abstract translation: 要解决的问题：即使在将米曲霉FAD-GDH和钌化合物组合使用的情况下，也能够提供能够测定葡萄糖浓度的葡萄糖传感器。 解决方案：葡萄糖传感器包括绝缘基板，具有工作电极的电极系统和设置在基板上的对电极以及设置在电极系统上的试剂层。 试剂层含有米曲霉FAD-GDH，钌化合物和PMS（吩嗪甲硫酸盐）。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013081448A

公开(公告)日：2013-05-09

申请号：JP2012082391

申请日：2012-03-30

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： HIRAI MITSUHARU ,  KUROSE KAORU ,  IGUCHI AKI

IPC: C12Q1/68 ,  C12N15/09

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: PROBLEM TO BE SOLVED: To provide a gene mutation detection probe capable of specifically detecting a particular gene mutation to be detected, which is not affected by a gene mutation other than the gene mutation to be detected even when a gene-encoding base sequence includes plural gene mutations.SOLUTION: A gene mutation detection probe for detection of a target gene mutation in a base sequence encoding a gene of interest that includes the target gene mutation and a non-target gene mutation includes an oligonucleotide such as a P1 oligonucleotide that has a base complementary to either a wild-type base or a mutant base of the target gene mutation, a base complementary to neither a wild-type base nor a mutant base of the non-target gene mutation, and has an identity of at least 80% with a base sequence complementary to the base sequence encoding the gene of interest.

Abstract translation: 待解决的问题：为了提供能够特异性检测待检测的特定基因突变的基因突变检测探针，其即使在基因编码基质时也不受基因突变以外的基因突变的影响 序列包括多个基因突变。 解决方案：用于检测编码目标基因突变和非靶基因突变的感兴趣基因的碱基序列中的靶基因突变的基因突变检测探针包括：寡核苷酸，例如具有 与靶基因突变的野生型碱基或突变型碱基互补的碱基，与野生型碱基和非靶基因突变的突变型碱基互补的碱基，并且具有至少80％的同一性， 与编码目的基因的碱基序列互补的碱基序列。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013079932A

公开(公告)日：2013-05-02

申请号：JP2012060101

申请日：2012-03-16

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： SHIMOMURA YUKA ,  YAMADA MAYUMI

IPC: G01N1/10 ,  C22B3/20

CPC classification number: G01N1/4055 ,  G01N1/4044 ,  G01N33/84 ,  G01N2001/4061

Abstract: PROBLEM TO BE SOLVED: To provide a method for recovering metal capable of easily recovering metal without using an organic medium.SOLUTION: A complex between a chelating agent and a metal in a specimen is formed in a mixed liquid prepared by mixing the chelating agent and the specimen under a pH condition where the chelating agent can be insoluble in an aqueous medium. Then, the complex is recovered from the mixed liquid, and further, the metal is recovered by dissolving the recovered complex in an aqueous medium under a pH condition that is different from the pH conditions where the chelating agent can be insoluble in an aqueous medium. By this method, metal can be easily recovered without using an organic medium.

Abstract translation: 要解决的问题：提供一种回收能够容易地回收金属而不使用有机介质的金属的方法。 解决方案：在螯合剂不溶于水介质的pH条件下，通过将螯合剂和样品混合而制备的混合液中形成螯合剂和试样中的金属络合物。 然后，从混合液中回收配合物，此外，通过将回收的络合物溶解在与螯合剂不溶于水性介质的pH条件不同的pH条件下在水性介质中回收金属。 通过这种方法，可以容易地回收金属而不使用有机介质。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JPWO2011062258A1

公开(公告)日：2013-04-11

申请号：JP2011541962

申请日：2010-11-19

Applicant: アークレイ株式会社

Inventor： 光春 平井 ,  光春 平井 ,  昌弘 小塚 ,  昌弘 小塚

IPC: C12N15/09 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: 核酸増幅法によりMTHFR遺伝子の目的領域を特異的に増幅するためのプライマーセットを提供する。F1プライマーとR1プライマーとを含むプライマーセット(1)、および、F2のプライマーとR2プライマーとを含むプライマーセット(2)を含むプライマーセットを使用する。これにより、例えば、同一反応液において同時に、MTHFR遺伝子の2種類の多型を生じる部分をそれぞれ含む2つの目的領域を増幅できる。(F1)塩基長が20〜28塩基長であり、配列番号1に示す塩基配列において、塩基番号8715のグアニン(g)を3’末端とするオリゴヌクレオチド(R1)塩基長が18〜26塩基長であり、配列番号1に示す塩基配列において、塩基番号8817のシトシン(c)を5’末端とするオリゴヌクレオチドに相補的なオリゴヌクレオチド(F2)塩基長が26〜36塩基長であり、配列番号1に示す塩基配列において、塩基番号10590のグアニン(g)を3’末端とするオリゴヌクレオチド(R2)塩基長が22〜34塩基長であり、配列番号1に示す塩基配列において、塩基番号10695のシトシン(c)を5’末端とするオリゴヌクレオチドに相補的なオリゴヌクレオチド

公开(公告)号：JP2013063062A

公开(公告)日：2013-04-11

申请号：JP2012164891

申请日：2012-07-25

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： HIRANO KATSUYASU

IPC: C12M1/00 ,  C12M1/34

CPC classification number: C12Q1/682 ,  C12Q1/6825 ,  C12Q2527/107 ,  C12Q2565/107

Abstract: PROBLEM TO BE SOLVED: To set an appropriate amplification factor for detecting with good precision the amount of target nucleic acid that has been amplified or melted.SOLUTION: A light reception section 14 receives fluorescence emitted according to the amount of the target nucleic acid that has been amplified by PCR by a light source 12 illuminating excitation light onto a reaction liquid. Electrical signals from the light reception section whose level depends on the received fluorescence intensity are amplified by plural amplification circuits 16a to 16n having different amplification factors from each other. A multiplexer 18 selects an electrical signal amplified with an amplification factor (for example 1 times) in an initial stage of an amplification reaction and detects a fluorescence value for that cycle. A CPU 30 acquires the largest fluorescence value in the initial stage and determines the amplification factor for a corrected stage to be (apparatus detection threshold value-margin)/largest value of the fluorescence value in initial stage, and inputs a selection signal to the multiplexer 18 to select the electrical signal amplified by the determined amplification factor. In the corrected stage, the electrical signal amplified with the determined amplification factor is selected and the fluorescence values are detected.

Abstract translation: 要解决的问题：为了设置适当的扩增因子，以高精度检测被扩增或熔化的靶核酸的量。 光接收部分14接收根据通过PCR扩增的目标核酸的量的荧光，其通过将激发光照射到反应液体上的光源12。 来自受光部的电信号依赖于接收到的荧光强度，由具有不同放大系数的多个放大电路16a〜16n放大。 多路复用器18选择在扩增反应的初始阶段以放大因子（例如1倍）放大的电信号，并检测该周期的荧光值。 CPU30获取初始阶段中最大的荧光值，并将校正阶段的放大系数确定为初始阶段的荧光值的（装置检测阈值 - 余量）/最大值，并将选择信号输入到多路复用器 18选择由确定的放大因子放大的电信号。 在校正阶段，选择用确定的放大因子放大的电信号，并检测荧光值。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP5170797B2

公开(公告)日：2013-03-27

申请号：JP2010507131

申请日：2009-03-02

Applicant: アークレイ株式会社

Inventor： 眞彦 福沢

IPC: G01N21/01

CPC classification number: A61B5/14532 ,  A61B5/01 ,  A61B2560/04

公开(公告)号：JP5166905B2

公开(公告)日：2013-03-21

申请号：JP2008031123

申请日：2008-02-12

Applicant: アークレイ株式会社

Inventor： 裕久 内田

IPC: G01N17/00 ,  G01N23/20

Abstract: PROBLEM TO BE SOLVED: To establish a method for preliminarily easily and simply evaluating the laser irradiation resistance of an organic optical crystal in a non-destructive manner in order to irradiate the organic optical crystal with a laser beam to continuously use it, and the organic optical crystal having laser irradiation resistance evaluated by the evaluation method. SOLUTION: The evaluation method for determining the presence of the laser irradiation resistance of the organic optical crystal by the diffractive analyzing process before the organic optical crystal is irradiated with the laser beam. Further, the organic optical crystal having laser irradiation resistance evaluated by the evaluation method is easily and simply provided to a wide field in a non-destructive manner. COPYRIGHT: (C)2009,JPO&INPIT

公开(公告)号：JP2013054029A

公开(公告)日：2013-03-21

申请号：JP2012170299

申请日：2012-07-31

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： TOGASHI TOMOKO ,  YAGI MASAYUKI

IPC: G01N33/53 ,  G01N33/48 ,  G01N33/543 ,  G01N33/545 ,  G01N33/553

CPC classification number: G01N33/6812 ,  G01N33/54313

Abstract: PROBLEM TO BE SOLVED: To provide a new assay method for simply and accurately assaying CMA.SOLUTION: The method of assaying Carboxymethyl arginine in a sample includes processing the sample with a pretreatment agent containing urea, and assaying the Carboxymethyl arginine in the pretreated sample with an immunological method.

Abstract translation: 要解决的问题：提供用于简单且准确地测定CMA的新的测定方法。 解决方案：测定样品中羧甲基精氨酸的方法包括用含尿素的预处理剂处理样品，并用免疫学方法测定预处理样品中的羧甲基精氨酸。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013033031A

公开(公告)日：2013-02-14

申请号：JP2012139417

申请日：2012-06-21

Applicant: Arkray Inc ,  アークレイ株式会社

Inventor： OKUBO AKIO ,  NAKAMURA TSUTOMU

IPC: G01N21/27 ,  G01J3/28

CPC classification number: G01N21/274 ,  G01J3/0267 ,  G01J3/027 ,  G01J3/10 ,  G01J3/32 ,  G01J3/42 ,  G01N21/31 ,  G01N21/78

Abstract: PROBLEM TO BE SOLVED: To compensate absorbance, when measurement is done for each individual spectroscopic measuring tool, with the length of an optical path over which light passes a checked substance.SOLUTION: A light emitting unit 11 irradiates a checked substance 3 held by a spectroscopic measuring tool 2 with light rays of a plurality of wavelengths. A light receiving unit 13 receives the light rays of the plurality of wavelengths having passed the checked substance 3. A detecting unit 14 detects wavelength component absorbance from the light rays received by the light receiving unit 13. An optical path length calculating unit 16 compares, out of the pieces of wavelength component absorbance detected by the detecting unit 14, the wavelength component absorbance of light rays absorbed by pigment that absorbs light rays of other wavelengths than the light wavelengths absorbed by analytical object contained in the checked substance 3, and the prescribed values of those wavelength component absorbance, and calculates the length of the optical path over which light passes the checked substance 3. A compensating unit 17 compensates the wavelength component absorbance detected by the detecting unit 14 for other wavelengths than those of the light rays absorbed by pigment with the optical path lengths calculated by the optical path length calculating unit 16, and thereby calculates the compensated wavelength component absorbance in a reference optical path length.

Abstract translation: 要解决的问题：为了补偿吸光度，当对每个单独的光谱测量工具进行测量时，具有光通过所检查物质的光路的长度。 解决方案：发光单元11用由多个波长的光线照射由光谱测量工具2保持的检查物质3。 光接收单元13接收通过了检查物质3的多个波长的光线。检测单元14检测由光接收单元13接收的光线的波长分量吸光度。光程长度计算单元16， 在由检测单元14检测到的波长分量吸光度之中，吸收由包含在检查物质3中的分析对象吸收的光波长以外的其他波长的光吸收的光线的波长成分吸光度和规定的 这些波长分量吸光度的值，并且计算光通过所检查物质3的光路的长度。补偿单元17补偿由检测单元14检测的波长分量吸光度除了由 颜料，光路长度由光路长度计算 计算单元16，从而计算参考光路长度中的补偿波长分量吸光度。 版权所有（C）2013，JPO＆INPIT