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公开(公告)号：JPH07267992A
公开(公告)日：1995-10-17
申请号：JP6190594
申请日：1994-03-31
Applicant: HOECHST JAPAN
Inventor： KOYAMA MASAYOSHI , TAKAHASHI MIKIKO , DOI KAZUYUKI
Abstract: PURPOSE:To obtain a new protein plasma heparin binding protein 70 (PHBP-70), available from blood of a fetus and a neonate of mammals including humans, having a specific molecular weight and a specified amino acid, capable of manifesting growth promoting activities for fibroblasts and useful as a therapeutic agent, etc., for wounds. CONSTITUTION:This new protein PHBP-70 is obtained from blood of a fetus and a neonate of mammals including humans and has about 60-80 kDa molecular weight measured by the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) under reducing conditions and an amino-terminal sequence having an amino acid sequence expressed by the formula. Furthermore, the protein is capable of manifesting growth promoting activities for fibroblasts and useful as a therapeutic agent, etc., for wounds. This protein is prepared by adding an anticoagulant to a bovine blood plasma, adding IM barium chloride thereto, centrifuging the resultant mixture, collecting the produced white precipitate, dissolving the precipitate in a phosphoric acid buffer solution, treating the obtained solution with an anion exchanger, adsorbing and removing a vitamin K-dependent protein, treating a fraction without being adsorbed with a column immobilizing a heparin, a get filtration column and an anion exchange column and purifying the resultant eluate according to the reversed phase liquid chromatography.
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公开(公告)号：JPH07244443A
公开(公告)日：1995-09-19
申请号：JP6009294
申请日：1994-03-04
Applicant: HOECHST JAPAN
Inventor： NAKAMURA TORU , SUGIYAMA IKUO
Abstract: PURPOSE:To obtain a toner fixing device with a heat roll heated for the short warm-up time with low electric power by using a metallic pipe contg. a coiled heating wire disposed as a heat roll and coating the heating wire with a polybenzimidazole-based layer. CONSTITUTION:A metallic pipe 1 contg. a coiled heating wire 2 disposed as a heat source at the center is used as a heat roll. The heating wire 2 has been coated with a polybenzimidazole-based layer and the coated coiled heating wire 2 is disposed so that the temp. distribution of the surface of the heat roll is made uniform. The pipe 1 and the heating wire 2 are especially preferably kept in contact with each other from the viewpoint of thermal efficiency. In order to fix the position of the heating wire 2 in the pipe 1, packing 3 may be disposed in the gap in the pipe 1. The objective toner fixing device capable of warm-up for a short time with low electric power is obtd. and the size of this device can be reduced in accordance with the reduction of the diameter of the heat roll.
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公开(公告)号：JPH07126181A
公开(公告)日：1995-05-16
申请号：JP27647393
申请日：1993-11-05
Applicant: HOECHST JAPAN
Inventor： KOYAMA MASAYOSHI , TAKAHASHI MIKIKO , DOI KAZUYUKI
Abstract: PURPOSE:To provide a preventive and therapeutic agent for fracture, containing platelet factor 4 as the active component and having an ossification promotion effect. CONSTITUTION:This preventive and therapeutic agent contains human platelet factor 4 and bovine platelet factor 4 as the active components. The platelet factor 4(PF4) is useful for diseases related to osteoblast and especially for prevention and therapy of diseases such as fracture requiring promotion of differentiation and growth of bone since it promotes differentiation of osteoblast. For therapy of fracture, it is administrated most preferably by mixing it with a suitable gel-state base and applying locally and directly to an affected part. PF4 is very soluble in water and can be systemically administrated in the form of a water-soluble injection. Nasal or transpulmonary administration is also possible in the form of a fine-particle aerosol. The dosage is 1 to 100mug/ administration part/human/day in the case of local administration or 0.1 to 10mg/kg/day in the case of systemic administration.
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公开(公告)号：JPH07120914A
公开(公告)日：1995-05-12
申请号：JP26389093
申请日：1993-10-21
Applicant: HOECHST JAPAN
Inventor： NISHIKAWA MASAHITO
IPC: G03F7/004 , C07D251/18 , C07D251/66 , C08L61/04 , C08L61/06 , G03F7/022 , G03F7/039 , H01L21/027
Abstract: PURPOSE:To obtain a photoresist compsn. excellent, in adhesion to various substrates, especially an ITO substrate by incorporating novolak resin, a specified photosensitive agent and a specified adhesion improver. CONSTITUTION:Novolak resin, a photosensitive agent based on naphtho- quinonediazidosulfonic ester and a melamine deriv. and/or a guanamine deriv. as an adhesion improver are incorporated. The novolak resin may be produced by condensing m-cresol and aldehyde such as formaldehyde but it is preferably produced by condensing a mixture of m-cresol with one or more kinds of phenols selected from among p-cresol, 2,4-xylenol, 2,5-xylenol and 3,5-xylenol and an aldehyde.
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公开(公告)号：JPH0792440A
公开(公告)日：1995-04-07
申请号：JP24008693
申请日：1993-09-27
Applicant: MATSUSHITA ELECTRIC IND CO LTD , HOECHST JAPAN
Inventor： TAKADA NAOMI , NAKAO KENJI , ONISHI HIROYUKI , NAGAO KAZUYA
Abstract: PURPOSE:To provide a ferroelectric liquid crystal panel capable of maintaining a good display without generating stripelike defects even after long-time driving by layer dulling after continuous driving. CONSTITUTION:This panel has a ferroelectric liquid crystal 206 having a layer structure clamped between two sheets of substrates 205, 207, on at least one of which transparent electrodes are formed. This ferroelectric liquid crystal 206 is subjected to an electric field treatment under a temp. condition of 40 deg.C. A liquid crystal material which is formed by mixing a ONE-WING liquid crystal material to a pyrimidine liquid crystal material and is
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Patent Agency Ranking
公开(公告)号：JPH0792165A
公开(公告)日：1995-04-07
申请号：JP23464893
申请日：1993-09-21
Applicant: HOECHST JAPAN
Inventor： AKITA MIKIO , ENOMOTO KOICHI , TANAKA SHIGEAKI , HAMAMOTO YOKO
IPC: G01N33/53 , A61K39/395 , G01N33/68
Abstract: PURPOSE:To make it possible to classify a part of osteoporosis as one of autoimmune diseases by detecting an autoantibody in the blood serum of an osteoporosis patient using an osteospecific sialoprotein. CONSTITUTION:An antibody containing an osteospecific sialoprotein (BSP) as an antigen is present in the blood serum of an osteoporosis patient. A diagnostic agent therefor is present in the osseous tissue of an osteoporosis patient and contains an antigen which reacts on the antibody in the blood serum of human osteoporosis patient but does not react on the antibody in the blood serum of healthy human. For example, BSP extracted from the bone of a mammal, e.g. a bovine, is purified by ion exchange chromatography to produce a diagnostic agent. The purifies antigens are then fixed to a plastic microplate having 96 holes and caused to react on a sample, i.e., a blood serum of human, and an enzyme-labeled secondary antibody is further caused to react before the color development of enzyme is detected.
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公开(公告)号：JPH0717854A
公开(公告)日：1995-01-20
申请号：JP6237694
申请日：1994-03-31
Applicant: SHUDO KOICHI , HOECHST JAPAN
Inventor： SHUDO KOICHI , SUGIOKA TATSUO , INAZU MIZUHO , TANAKA HIDEYUKI , INOUE TSUTOMU , KITAMURA KAZUYUKI
IPC: A61K31/165 , A61K31/19 , A61K31/235 , A61K31/335 , A61K31/336 , A61K31/35 , A61K31/352 , A61K31/44 , A61K31/655 , A61P19/10 , A61P43/00 , C07D213/79 , C07D213/80 , C07D303/38 , C07D303/40 , C07D311/30
Abstract: PURPOSE:To provide the agent containing, as active ingredient, a specific aromatic carboxylic acid derivative, exhibiting remarkable effect for suppressing bone quantity decrease and osteogenesis, thus useful for curing and preventing osteopathy such as bone dysbolism, osteoporosis and fracture. CONSTITUTION:The anti-osteopathic agent can be obtained by formulating (A) as active ingredient, a compound (or a salt thereof) of formula I [R1-R5 are each H, lower or medium alkyl, lower or medium alkoxy (however, they are not H at the same time), combined adjacently, together with the carbon atoms bound thereto, into five-or six-membered cycloalkyl, etc.; R6 is OH, lower alkoxyl, etc.; X is a group of formula II (R9 is H or lower alkyl), of formula III (R10 is the same as R9), etc.; Y is a group of formula IV (W is H or OH) or formula V] {e.g. 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carboxyamidolbenzoic acid} with (B) additive(s) such as vehicle, disintegrant, binder and/or lubricant and by subjecting the resultant formulation to pharmaceutical manufacturing.
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公开(公告)号：JPH06265551A
公开(公告)日：1994-09-22
申请号：JP5025793
申请日：1993-03-11
Applicant: HOECHST JAPAN
Inventor： NISHIZAKI YUTAKA
IPC: G01N27/327 , G01N27/26 , G01N27/416 , G01N33/536 , G01N33/543
Abstract: PURPOSE:To determine a specimen with no influence of nonspecific agglutination by bringing a particle carrier sensitized by an immunoactive substance into contact with the specimen reactive specifically on the active substance and detecting variation of Zeta potential before and after contact. CONSTITUTION:Latex particles are employed as particle carrier and the type thereof is not limited. Various available antigens or antibodies are employed as immunoactive substance. Sodium chloride or potassium chloride dissolved into phosphoric acid buffer is employed as an electrolytic aqueous solution. According to normal immunoassay, the particle carrier sensitized by the immunoactive substance is suspended in the electrolytic aqueous solution and after measuring Zeta potential of the suspension, a specimen reactive specifically on the active substance is added to cause reaction and Zeta potential after reaction is measured. The specimen is determined based on the relationship between the potential difference before and after reaction and the concentration of the specimen. Since the specimen can be measured at low concentration, nonspecific agglutination can be suppressed during stock or measurement.
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公开(公告)号：JPH06247499A
公开(公告)日：1994-09-06
申请号：JP5482993
申请日：1993-02-19
Applicant: HOECHST JAPAN
Inventor： NIWA NOBUYUKI , MASUDA TOSHIHARU
Abstract: PURPOSE:To obtain a stable supplying method for chemicals into a CVD(chemical vapor phase device) by penetrating a part for integrally fixing an opening part or a wall of a pressure container, and providing a valved gas introducing pipe, a valved liquid chemical introducing hole and a discharging hole for applying pressure therebetween, in a double structure of the pressure container and a film container on the inner side thereof. CONSTITUTION:An interior container G formed by welding a taking-out parts formed by longitudinal two sheets made of PTFE and PFA is inserted into an external container made of pressure stainless, and composed of upper and lower end plates A, B, etc., and a chemical discharging pipe portion of a double structural container composed of an interior container fixing part H and a chemical introducing/discharging piping I is connected to a CVD device, moreover positive silicic acid ethyl is filled into the interior container from the introducing pipe side by using high purity He gas. A wafer is set in the CVD device, and the temperature is set to 400 deg.C, moreover positive silicic acid ethyl is forcibly fed from the container. Pressure difference is provided in the piping whose aperture becomes smaller, ortho-silicic acid ethyl is vaporized and inserted into the CVD device, thereby uniform silicon oxide film can be obtained.
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公开(公告)号：JPH06244099A
公开(公告)日：1994-09-02
申请号：JP5154893
申请日：1993-02-17
Applicant: HOECHST JAPAN
Inventor： TAKEDA TAKASHI
IPC: H01L21/30 , G03F7/42 , H01L21/027 , H01L21/306
Abstract: PURPOSE:To dissolve photoresist readily at a relatively low temperature, to completely remove it and to enable water cleaning in a process after removal by adding at least one kind of an imino-bis-alkylamine group. CONSTITUTION:Photoresist removing solution is mainly composed of an imino- bis-alkylamine group expressed by the formula (R is hydrogen atom, a 1 to 3C alkyl group or a 1 to 3C hydroxyalkylamine group, and each of n and m is an integer of 1 to 3). Methylimino-bis propylamine is especially desirable for the imino-bis-alkylamine group. The imino-bis-alkylamine group is used alone or mixed with two or more kinds. The ratio of imino-bis-alkylamine group in the removing solution is in a range of 10 to 100wt.%. Thereby, photoresist can be completely removed and a process after treatment can be finished just by water cleaning.
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