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1.发明专利Cultivation of lawsonia intracellularis, anti-lawsonia intracellularis vaccine and diagnostic agent 有权罗非鱼细菌内毒素，抗病毒细菌疫苗和诊断试剂的培养
公开(公告)号：JP2006061165A
公开(公告)日：2006-03-09
申请号：JP2005304585
申请日：2005-10-19
发明人： KNITTEL JEFFREY P , ROOF MICHAEL B
IPC分类号： C12N1/20 , G01N33/554 , A61K39/02 , A61K39/07 , A61K39/106 , A61K39/40 , A61P1/00 , A61P31/04 , C07K16/12 , C12N1/00 , C12N1/36 , C12N5/06 , C12N9/92 , C12Q1/02 , G01N33/53 , G01N33/569
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/521 , A61K2039/522 , A61K2039/552 , C07K16/1203 , C12N1/20 , G01N33/56911 , G01N33/56922 , G01N2333/195 , G01N2469/20 , Y10S424/825
摘要： PROBLEM TO BE SOLVED: To provide a method for large scale cultivation of Lawsonia intracellularis, and a non-toxic attenuated strain and a method for producing the same, and further a method for detecting an antibody against Lawsonia intracellularis using the obtained cultured cells, and a vaccine. SOLUTION: In the cultivation, cultured cells are inoculated with the Lawsonia intracellularis bacteria, and incubated in a reduced oxygen concentration and the infected cells are maintained in suspension to culture the cells. The attenuated Lawsonia intracellularis strain is also obtained by subcultivation of the infected cultured cells. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译： 待解决的问题：提供一种用于大规模培养细胞内劳森氏菌的方法和一种无毒性减毒菌株及其制备方法，还提供一种使用获得的培养物检测细胞内劳森氏菌抗体的方法 细胞和疫苗。 解决方案：在培养中，培养的细胞接种细胞内劳森氏菌，并以减少的氧浓度进行培养，将感染的细胞保持在悬浮液中以培养细胞。 减毒的细胞内劳森氏菌菌株也通过感染的培养细胞的继代培养获得。 版权所有（C）2006，JPO＆NCIPI
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2.发明专利Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents 有权LAWSONIA细胞内细胞培养，抗病毒细菌疫苗和诊断试剂
公开(公告)号：JP2007151554A
公开(公告)日：2007-06-21
申请号：JP2006355093
申请日：2006-12-28
发明人： KNITTEL JEFFREY P , ROOF MICHAEL B
IPC分类号： C12N1/20 , G01N33/554 , A61K39/02 , A61K39/106 , A61K39/40 , A61P1/00 , A61P1/04 , A61P31/04 , C07K16/12 , C12N1/00 , C12N1/36 , C12N5/06 , C12N9/92 , C12Q1/02 , G01N33/569
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/521 , A61K2039/522 , A61K2039/552 , C07K16/1203 , C12N1/20 , G01N33/56911 , G01N33/56922 , G01N2333/195 , G01N2469/20 , Y10S424/825
摘要： PROBLEM TO BE SOLVED: To provide a method for large scale cultivation of Lawsonia intracellularis and a non-toxic attenuated strain thereof and a production method thereof, furthermore, a method for detecting an antibody to L. intracellularis using the obtained cultured bacteria and an anti-L. intracellularis vaccine. SOLUTION: In this method, the cultured cells are cultured by inoculating the cells with L. intracellularis bacteria, incubating the cells in a reduced oxygen concentration and maintaining the infected cells in suspension. The attenuated L. intracellularis strain is also obtained by sub-culturing the infected cultured cells. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译： 待解决的问题：提供一种大规模培养细胞内劳森氏菌及其无毒性减毒菌株的方法及其制备方法，此外，使用获得的培养细菌检测细胞内抗细胞因子的方法 和抗L。 细胞内毒素疫苗。 解决方案：在这种方法中，培养的细胞通过用细胞内细菌细菌细胞接种细胞进行培养，将细胞以降低的氧浓度孵育，并将感染的细胞保持在悬浮液中。 通过亚培养感染的培养细胞也可以获得减毒的细胞内酵母菌菌株。 版权所有（C）2007，JPO＆INPIT
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3.发明专利Live vaccine containing attenuated avirulent strain of lawsonia intracellularis 有权含有衰老的LAWSONIA细胞内毒素的活体疫苗
公开(公告)号：JP2008266340A
公开(公告)日：2008-11-06
申请号：JP2008124788
申请日：2008-05-12
发明人： KNITTEL JEFFREY P , ROOF MICHAEL B
IPC分类号： A61K39/02 , G01N33/554 , A61K39/106 , A61K39/40 , A61P1/04 , A61P31/04 , C07K16/12 , C12N1/00 , C12N1/20 , C12N1/36 , C12N5/06 , C12N9/92 , C12N15/09 , C12Q1/02 , G01N33/569
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/521 , A61K2039/522 , A61K2039/552 , C07K16/1203 , C12N1/20 , G01N33/56911 , G01N33/56922 , G01N2333/195 , G01N2469/20 , Y10S424/825
摘要： PROBLEM TO BE SOLVED: To provide a method of a large scale cultivation of Lawsonia intracellularis, its avirulent attenuated strain, its manufacturing process, and a live vaccine containing Lawsonia intracellularis using the cultured bacteria obtained. SOLUTION: Cultured cells are inoculated with Lawsonia intracellularis bacteria and incubated in a reduced oxygen concentration, and the infected cells are maintained in suspension and cultured. The avirulent Lawsonia intracellularis strain is obtained by passageing the infected cells. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译： 要解决的问题：提供一种大规模培养细胞内劳森氏菌，其无毒性减毒菌株，其制备方法和使用所获培养细菌的含有劳森氏菌的活疫苗的方法。 解决方案：将培养的细胞接种细胞内劳森氏菌细菌并以降低的氧浓度进行培养，将感染的细胞保持悬浮并培养。 通过传代感染的细胞获得无毒力的劳森氏菌菌株。 版权所有（C）2009，JPO＆INPIT
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