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    Antibacterial vaccine composition
    1.
    发明专利
    Antibacterial vaccine composition 审中-公开
    抗生素疫苗组合物

    公开(公告)号：JP2011097938A

    公开(公告)日：2011-05-19

    申请号：JP2010247585

    申请日：2010-11-04

    申请人： Pharmacia & Upjohn Co Llc ,  ファルマシア・アンド・アップジョン・カンパニー・エルエルシー

    发明人： LOWERY DAVID E ,  FULLER TROY E ,  KENNEDY MICHAEL J

    IPC分类号： C12N1/21 ,  G01N33/50 ,  A61K39/102 ,  A61K39/39 ,  A61P31/04 ,  C07K14/285 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/569 ,  G01N33/577

    CPC分类号： C07K14/285 ,  A61K2039/522

    摘要： PROBLEM TO BE SOLVED: To identify a pathogenic gene of gram-negative bacterium, thereby allowing the identification of a new antibacterial agent that targets the pathogenic gene and a product thereof, and to provide a new gram-negative bacterial mutant useful in vaccines.
    SOLUTION: An attenuated Pasteurella (Mannheimia) haemolytica bacterium is provided, being such that: a mutation is introduced into a gene represented by a polynucleotide sequence encoding atpG polypeptide to effect modification so as to decline in the expression of a gene product encoded by the gene and cause the expression of an inactive gene product. Besides, an immunogenic composition and a vaccine composition each containing the gene are also provided.
    COPYRIGHT: (C)2011,JPO&INPIT

    摘要翻译： 要解决的问题：为了鉴定革兰氏阴性细菌的致病基因，从而允许鉴定靶向致病基因的新抗菌剂及其产物，并提供可用于新鲜革兰氏阴性菌的新型革兰氏阴性细菌突变体 疫苗。 解决方案：提供减毒巴斯德氏菌（Mannheimia）溶血霉菌，使得：将突变引入到由编码atpG多肽的多核苷酸序列表示的基因中进行修饰，以使编码的基因产物的表达下降 通过该基因导致无活性基因产物的表达。 此外，还提供了各自含有该基因的免疫原性组合物和疫苗组合物。 版权所有（C）2011，JPO＆INPIT

    3-(CONDENSED RING-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES AND 3-(NITROGEN ATOM-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES
    4.
    发明专利
    3-(CONDENSED RING-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES AND 3-(NITROGEN ATOM-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES 失效

    公开(公告)号：JPH1180139A

    公开(公告)日：1999-03-26

    申请号：JP19194998

    申请日：1998-07-07

    申请人： UPJOHN CO

    发明人： BRICKNER STEVEN J

    IPC分类号： C07D263/24 ,  A61K31/42 ,  A61K31/421 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04 ,  C07D263/20 ,  C07D413/04

    摘要： PROBLEM TO BE SOLVED: To obtain a new 3-(condensed ring-substituted) phenyl-5β- amidomethyloxazolidinone useful as an antimicrobial agent. SOLUTION: This 3-(condensed ring-substituted) phenyl-5β-(amidomethyl) oxazolidin-2-one is shown by formula I [R1 is H, an alkyl, a cycloalkyl, an alkenyl, phenyl, pyridyl, etc.; either R2 or R4 is H and the other and R3 form a group of formula II (n3 and n4 are each 0-3; n7 and n are each 0 or 1; R10-1 and R10-2 are each H, an alkyl, etc.; R10-3 and R10-4 are each as shown for R10-1 and R10-2 ), etc.; either R5 or R6 is H and the other is H, an alkyl, etc.], and its pharmaceutically permissible salt such as 3-(1'-oxo-2'α-methyl-5'- indanyl)-5β-(acetamidomethyl)oxazolidin-2-one. The compound of formula I is prepared by obtaining a compound of formula IV through three processes from a compound of formula III, then forming a compound of formula V, reducing the compound with H2 and further acylating the resulting compound.

    COMPOSITION CONTAINING 3-GUANIDINOPROPIONIC ACID
    9.
    发明专利
    COMPOSITION CONTAINING 3-GUANIDINOPROPIONIC ACID 失效

    公开(公告)号：JPH0820534A

    公开(公告)日：1996-01-23

    申请号：JP17854695

    申请日：1995-07-14

    申请人： UPJOHN CO

    发明人： MAATEIN DAARAMU MEGURATSUSON

    IPC分类号： A23K1/16 ,  A61K9/00 ,  A61K9/08 ,  A61K9/48 ,  A61K31/155 ,  A61K31/185 ,  A61K31/19 ,  A61K31/195 ,  A61P3/00 ,  A61P3/06 ,  A61P3/08 ,  A61P5/00

    摘要： PROBLEM TO BE SOLVED: To obtain a composition for reducing the fat content of the farm animals, and increasing the muscle and protein contents thereof. SOLUTION: This composition consists of 3-guanidinopropionic acid or medically acceptable salts thereof in an effective amount, and is used for producing an animal product having less fat content. The composition is administered by mixing with a feed, or by injecting or using a mobile sustained release apparatus. By the administration of 3-guanidinopropionic acid, it is possible to treat or prevent certain kinds of metabolic disorders in humans and animals e.g. hyperglycemia, glucose tolerance disorder, hyperinsulinemia, insulin insensitivity, hypermylinemia, adposis or hyperlipidemia.