摘要:
PROBLEM TO BE SOLVED: To provide an active component capable of stimulating the direct or indirect expression of type 2 and/or type 3 human β-defensin without inducing inflammation, irritation or hypersensitive reaction. SOLUTION: The increase of the amount of β-defensin in human skin prevents the pathogenic specific species (Staphylococcus aureus) from invading excessively into an ecosystem of a body, and contributes for protecting the skin and keeping it to be healthy. The active component is selected from the roots of mugwort, horseweed, bark of a red-berried elder, etc., or their extract, α-MSH, one of its constituting peptides and substance resembling to the peptides. The active components can be used as a cosmetic composition containing the same by 0.01-10 wt. %. Also, the active components can be used as medicinally permissible excipients. As the method for screening the active components without causing inflammation, a skin bio-test method using epithelial cells such as keratinocytes, cornecytes, etc., is cited. COPYRIGHT: (C)2004,JPO
摘要:
PROBLEM TO BE SOLVED: To provide an active ingredient capable of stimulating direct or indirect expression of type 2 and/or type 3 human beta-defensins. SOLUTION: The active ingredient capable of stimulating direct or indirect expression of type 2 and/or type 3 human beta-defensins without causing any inflammatory, irritation or hypersensitive reaction is chosen from (i) an extract chosen from the group consisting of a quinoa extract, a boldo extract and a mixture of the quinoa and boldo extracts, (ii) jasmonic acid and (iii) mixtures thereof. A cosmetic or pharmaceutical composition containing the active ingredient at a concentration ranging from 0.001 wt.% to 20 wt.% exerts a bactericidal or antifungal property. A screening method for the selection of such active ingredient is also provided. COPYRIGHT: (C)2008,JPO&INPIT