公开(公告)号：JP5291930B2

公开(公告)日：2013-09-18

申请号：JP2007507148

申请日：2006-03-08

Applicant: 独立行政法人科学技術振興機構

Inventor： 鈴木　　孝治 ,  洋希 一二三 ,  伸弘 谷本 ,  恵 牧野

IPC: A61K49/00 ,  C07C237/04 ,  C07D323/00 ,  C07F5/00 ,  G01R33/28

CPC classification number: C07D323/00 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07C237/10 ,  C07D257/02 ,  C07F5/025

Abstract: Novel gadolinium complex compounds responsive to ions and compounds other than zinc ion, as well as MRI probes made of the compounds are disclosed. Since the gadolinium complex compounds of the present invention such as that represented by the following structural formula exhibit responsiveness to potassium ion, calcium ion, glucose or the like, by using the gadolinium complex compounds of the present invention as a MRI probe, the ion or compound in a living body can be detected and concentration distribution thereof may be determined.