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公开(公告)号：JP2011213731A
公开(公告)日：2011-10-27
申请号：JP2011147503
申请日：2011-07-01
IPC分类号： A61K45/00 , A61K9/127 , A61K31/409 , A61K41/00 , A61K47/24 , A61K47/34 , A61P1/02 , A61P1/04 , A61P11/00 , A61P15/00 , A61P17/00 , A61P31/00 , A61P35/00
CPC分类号： A61K41/0071 , A61K9/127
摘要： PROBLEM TO BE SOLVED: To provide an improved photosensitizer formulation for use in photodynamic therapy (PDT).SOLUTION: The pharmaceutical liposomal formulation for photodynamic therapy comprises a liposomal bilayer which consists substantially of phospholipids, and a therapeutically effective amount of a non-polar photosensitizer. It is another object of the present invention to incorporate non-polar photosensitizers into a liposomal membrane thus allowing non-polar and polar substances to be transported using the same vesicle. It is a further object of the present invention to preserve the structure and size of liposomal constructs with incorporated non-polar photosensitizer during freeze-drying processes by adding monosaccharides or polyalcohols as cryoprotectants.
摘要翻译： 要解决的问题：提供用于光动力学治疗（PDT）的改进的光敏剂制剂。解决方案：用于光动力学治疗的药物脂质体制剂包含基本上由磷脂组成的脂质体双层和治疗有效量的非极性光敏剂 。 本发明的另一个目的是将非极性光敏剂掺入脂质体膜中，从而允许使用相同囊泡输送非极性和极性物质。 本发明的另一个目的是通过加入单糖或多元醇作为冷冻保护剂，在冷冻干燥过程中通过掺入的非极性光敏剂来保持脂质体构建体的结构和大小。
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公开(公告)号：JP2010269173A
公开(公告)日：2010-12-02
申请号：JP2010177235
申请日：2010-08-06
发明人： NEUBERGER WOLFGANG
CPC分类号： A61B18/24 , A61B18/20 , A61B2017/00075 , A61B2018/00196 , A61B2018/00636
摘要： PROBLEM TO BE SOLVED: To provide a system and method for controllably releasing laser radiation in percutaneous laser radiation treatment. SOLUTION: An optical fiber is inserted below the skin or into a vascular lumen to a predetermined point. The fiber is connected to a source of electromagnetic radiation such as a laser. Radiation is then delivered to the treatment site while the fiber is simultaneously drawn out to the entry point. The fiber is manually withdrawn at a rate and the radiation is administered at a power or energy level. To maintain a constant proper energy density, the speed of withdrawal is measured and sent to a controlling mechanism. The controlling mechanism modifies the power emitted, pulse length or pulse rate to ensure that the vein or tissue receives a consistent dose of energy. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译： 要解决的问题：提供一种用于在经皮激光辐射治疗中可控地释放激光辐射的系统和方法。 解决方案：将光纤插入皮肤下方或插入血管腔至预定点。 光纤连接到诸如激光的电磁辐射源。 然后将辐射递送到治疗部位，同时将纤维同时拉出到入口点。 以一定速率手动取出纤维，辐射以功率或能量水平施用。 为了保持恒定的适当的能量密度，测量提取速度并将其发送到控制机制。 控制机制改变发射功率，脉冲长度或脉率，以确保静脉或组织接受一致的能量。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2009079050A
公开(公告)日：2009-04-16
申请号：JP2008256022
申请日：2008-10-01
CPC分类号： A61Q9/04 , A61K8/0241 , A61K8/49 , A61K2800/412 , A61K2800/438 , A61K2800/56 , A61K2800/81 , A61K2800/82 , A61K2800/83 , A61Q9/00
摘要： PROBLEM TO BE SOLVED: To provide a means of attaining permanent or semipermanent dehairing to remove an unnecessary hair without the risk of a scar and infection (frequently occurs in an electrolytic method) targeting a follicle after dehairing from it, and its method.
SOLUTION: In this method, a permanent/semipermanent dehairing composition, which is activated by a chromophore, a photosensitizer, an ultrasound sensitive agent, and a chemical means, and formed in a non-spherical minute particle having a size of not smaller than 10 μm but not larger than 50 μm, is introduced after removing an unnecessary hair, in a follicle to alter and/or kill the cell contributing to the growth of a hair by activating the compound by electromagnetic irradiation, ultrasonic irradiation, etc.
COPYRIGHT: (C)2009,JPO&INPIT摘要翻译： 要解决的问题：提供一种获得永久性或半永久性脱毛的方法，以去除不需要的毛发，而不会在脱毛后对毛囊进行针对毛发的瘢痕和感染（在电解方法中经常发生）的风险及其方法 。 解决方案：在该方法中，由发色团活化的永久性/半永久性脱毛组合物，光敏剂，超声波敏感剂和化学方法，并形成在非球形微粒中，其尺寸不为 在除去毛发后不必要的头发，通过电磁辐射，超声波照射等激活化合物来改变和/或杀死有助于毛发生长的细胞，从而引入小于10μm，但不大于50μm的物质。 版权所有（C）2009，JPO＆INPIT
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