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公开(公告)号：JP2006104115A
公开(公告)日：2006-04-20
申请号：JP2004291996
申请日：2004-10-04
申请人： Fuji Photo Film Co Ltd , Japan Science & Technology Agency , Tohoku Univ , 国立大学法人東北大学 , 富士写真フイルム株式会社 , 独立行政法人科学技術振興機構
发明人： IHARA MASATAKA , TAKASU KIYOMASA , KHANITHA PUDHOM , KITAGUCHI HIROSHI , KAWAKAMI MASAYUKI , SATO KOZO
IPC分类号： A61K31/428 , A61K31/4439 , A61K31/4709 , A61P33/00 , C07D417/14
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4439 , A61K31/4709
摘要： PROBLEM TO BE SOLVED: To obtain an anti-trypanosomiasis agent having high prophylactic or therapeutic effects on trypanosomiasis. SOLUTION: This anti-trypanosomiasis agent comprises a compound represented by formula (1) (wherein, R 1 and R 2 denote each hydrogen atom, a halogen atom, hydroxy group, oxygen atom, a 1-5C alkyl group, a 1-5C alkoxy group, a 5-8C aryl group, a 5-8C aryloxy group, a 2-6C alkoxycarbonyl group or a 2-6C alkylaminocarbonyl group and may mutually be bound; R 3 , R 4 and R 5 denote each a 1-5C alkyl group or a 5-8C aryl group; R 6 and R 7 denote each hydrogen atom, a halogen atom, hydroxy group, oxygen atom, a 1-8C alkyl group, a 1-5C alkoxy group, a 5-8C aryl group, a 5-8C aryloxy group or a 2-6C alkoxycarbonyl group and may mutually be bound; Y and Z form each a 5- or a 6-membered heterocyclic ring; (m) and (n) denote each 0 or 1; Q denotes a physiologically acceptable anion; and (k) denotes an integer of 0-2). COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译： 待解决的问题：获得对锥虫病具有高预防或治疗作用的抗锥虫病药。 解决方案：该抗锥虫病药包含式（1）表示的化合物（其中，R 1和R 2各自表示氢原子，卤素原子， 羟基，氧原子，1-5C烷基，1-5C烷氧基，5-8C芳基，5-8C芳氧基，2-6C烷氧基羰基或2-6C烷基氨基羰基，并且可以相互 结合; R 3，R 3，R SP 3，R SP 3，R SP 5，各自表示1-5C烷基或5-8C芳基; R“ SP> 6 和R
7 表示每个氢原子，卤素原子，羟基，氧原子，1-8C烷基，1-5C烷氧基，5-8C 芳基，5-8C芳氧基或2-6C烷氧基羰基，可以相互结合; Y和Z各自形成5-或6-元杂环;（m）和（n）分别表示0或1 ; Q表示生理上可接受的阴离子;（k）表示0-2的整数）。 版权所有（C）2006，JPO＆NCIPI -
公开(公告)号：JPH11218885A
公开(公告)日：1999-08-10
申请号：JP1753598
申请日：1998-01-29
发明人： TAGUCHI TOSHIKI , SATO KOZO
IPC分类号： G03C8/10
摘要： PROBLEM TO BE SOLVED: To obtain a silver halide photographic sensitive material capable of forming a lightfast dye image by incorporating a dye donative compound partially having a cyan dye structure. SOLUTION: This photosensitive material contains on a support at least one of the dye donative compounds represented by formula I: (Dye-X)q -Y in which Dye is a cyan dye group or its precursor group represented by formula II; X is a simple bond or a bonding group; Y is a group having a function for releasing Dye in reverse accordance with reduction of silver halide to silver and causing different in diffusibility between the released dye and the compound of the formula I; Dye and X combine with one of Bn group in the formula II; and (q) is 1 or 2; in the formula II, each of A1 and A2 is the H atom or an alkyl group or the like; G is a carbonyl group or the like; R is an alkyl group; each of Z1 and Z2 is an atomic group necessary to form an aromatic ring or the like; Bn are a group of substituents on Z2 ; and (n) is an integer of 1-5.
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公开(公告)号：JPH09258400A
公开(公告)日：1997-10-03
申请号：JP6806896
申请日：1996-03-25
发明人： SATO KOZO
摘要： PROBLEM TO BE SOLVED: To obtain a dye-forming coupler giving a dye superior in hue and good in lightfasteness by incorporating at least one kind of dye-forming coupler. SOLUTION: The silver halide color photographic sensitive material contains the 1H-pyrrolo[1,2-C][1,2,3] triazole type dye-forming coupler represented by the formula in which each of R1 and R2 is an H atom or a substituent, preferably, each is an electron withdrawing group having a Hammett's substituent constant δp of >=0.3 and X is an H atom or a group to be released by reaction with the oxidation product of a color developing agent. Thus coupler exhibits absorption characteristics preferable as a yellow or orange dry in the case of oxidation coupling with a hydrazine derivative color-developing reducing agent, thus permitting the dye obtained by the coupler to be superior in spectral absorption characteristics and good color reproduction performance and a color image obtained by this coupler to be superior in lightfastness.
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公开(公告)号：JPH09146245A
公开(公告)日：1997-06-06
申请号：JP30130195
申请日：1995-11-20
发明人： WATANABE KATSUYUKI , OKAMURA HISASHI , SATO KOZO
摘要： PROBLEM TO BE SOLVED: To form an image excellent in preservability and having a high S-N ratio with a specified precursor of a coloring dye excellent in aging stability and coloring ability by holding the precursor on a substrate. SOLUTION: This photosensitive material contains at least one kind of precursor of a coloring dye represented by formula I on the substrate. In the formula I, each of R1 -R3 is H, halogen, cyano, alkyl, etc., R4 is H, alkyl, aryl, etc., R5 is an electron withdrawing substituent, R6 is alkyl or aryl, and A is hydroxyl or dialkylamino, preferably hydroxyl or
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公开(公告)号：JPH0621254B2
公开(公告)日：1994-03-23
申请号：JP9976888
申请日：1988-04-22
发明人： KAMIO TAKAYOSHI , SATO KOZO
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公开(公告)号：JPH05339273A
公开(公告)日：1993-12-21
申请号：JP14718992
申请日：1992-06-08
发明人： YAMAKAWA KAZUYOSHI , SATO KOZO , SUGIME TAKASHI
IPC分类号： C07D495/04 , C07D519/00
摘要： PURPOSE:To obtain a new compound useful as an intermediate for producing ticlopidine hydrochloride having antithrombotic action. CONSTITUTION:Compound of formula I and formula II (R is H or alkyl) such as 3-amino-5-o-chlorobenzyl-4,5,6,7-tetrahydrothieno [3,2c]pyridine-2-carboxylic acid methyl ester. The compound of formula I is obtained by decomposing amide bond of a compound of formula III (R is alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, etc.) under an acidic condition to give a compound of formula II and then subjecting this compound to o-chlorobenzylation.
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公开(公告)号：JPH05339272A
公开(公告)日：1993-12-21
申请号：JP14718892
申请日：1992-06-08
发明人： YAMAKAWA KAZUYOSHI , SATO KOZO , SUGIME TAKASHI
IPC分类号： C07D495/04 , C07D519/00
摘要： PURPOSE:To obtain a new compound useful as an intermediate for producing ticlopidine hydrochloride having antithrombotic action. CONSTITUTION:A compound of formula I (R is alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, alkoxycarbonyl, aryloxycarbonyl, etc.; R is H or alkyl) such as 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid methyl ester. The compound of formula I is obtained by reacting a 3-cyano-4- piperidone derivative of formula II with a sulfonic acid halide of formula III (R is alkyl or aryl; X is halogen) to produce a 3-cyanotetrahydropyridine of formula IV and reacting this derivative with a thioglycolic acid of formula V or its ester in the presence of a base.
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