公开(公告)号：JP2000080066A

公开(公告)日：2000-03-21

申请号：JP16945199

申请日：1999-06-16

申请人： MITSUI CHEMICALS INC

发明人： YAMASHITA HIROYUKI ,  TOGASHI KAZUHIKO ,  KAI AKIYOSHI ,  MORI JUNICHI ,  MORI HARUKI ,  KAWAI KOICHI ,  KOYABE AKIHIRO ,  SATO TAKASHI

IPC分类号： C07D295/08 ,  A61K31/00 ,  A61K31/165 ,  A61K31/167 ,  A61K31/34 ,  A61K31/341 ,  A61K31/35 ,  A61K31/351 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/00 ,  A61P9/06 ,  C07C235/64 ,  C07C311/08 ,  C07C317/44 ,  C07D307/22 ,  C07D307/68 ,  C07D309/08

摘要： PROBLEM TO BE SOLVED: To obtain a new anilide derivative useful as an active ingredient for new type antiarrhythmic medicines having high safety and free from a ventricular function-inhibiting action and an arhythmia-stimulating action. SOLUTION: An anilide derivative of formula I (R1 is a 1-3C alkoxy, a 1-3C alkyl or the like; R2, R3 are each H, a 1-3C alkoxy, a 1-3C alkyl or the like; R4, R5 are each H, a 1-4C alkyl, a 3-6C cycloalkyl or the like) or its pharmacologically acceatable salt, for examale, 4'-[2-(ethylamino) ethoxy]-2-(methanesulfonamido)benzanilide. The anilide derivative of formula I is obtained, for example, by condensing a carboxylic acid derivative of formula II with an aniline derivative of formula III in the presence of a condensing agent such as dicyclohexylcarbodiimide or carbonyldiimidazole. The anilide derivative of formula I can be used as an active ingredient to provide an antiarrhythmic medicine not affecting an ventricular function, especially an auricular arrhythmia-treating medicine.

公开(公告)号：JP2001151742A

公开(公告)日：2001-06-05

申请号：JP33524499

申请日：1999-11-26

申请人： MITSUI CHEMICALS INC

发明人： YAMASHITA HIROYUKI ,  TOGASHI KAZUHIKO ,  KAI AKIYOSHI ,  MORI JUNICHI ,  MORI HARUKI ,  KAWAI KOICHI ,  KOYABE AKIHIRO ,  SATO TAKASHI

IPC分类号： C07D295/00 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/5375 ,  A61P9/06 ,  C07C235/64 ,  C07C235/88 ,  C07C237/42 ,  C07C237/50

摘要： PROBLEM TO BE SOLVED: To obtain a new antiarrhythmic agent having no effect on cardiac function. SOLUTION: This antiarrhythmic agent comprises a new anilide derivative represented by the general formula. The antiarrhythmic agent is applicable also to patients lowered in cardiac function and excellent in safety.

公开(公告)号：JPH1149771A

公开(公告)日：1999-02-23

申请号：JP21080497

申请日：1997-08-05

申请人： MITSUI CHEMICALS INC

发明人： YAMASHITA HIROYUKI ,  FUJIWARA JUNYA ,  MORI HARUKI ,  KAWAI KOICHI ,  KOYABE AKIHIRO

IPC分类号： C07D405/04 ,  A61K31/415 ,  A61P13/02 ,  A61P15/00

摘要： PROBLEM TO BE SOLVED: To obtain a new compound selectively acting on α1 receptor of urethral smooth muscle, having little adverse effects such as increased blood pressure, and useful for treatment of incontinence of urine. SOLUTION: This new compound is a compound expressed by formula I (R is a 1-6C alkyl; R is H, OH or a 1-6C alkyloxy) or a salt thereof, e.g. 4-(2-imidazolinyl)-8-(methylsufonylamino)chroman. The compound of formula II is obtained by using 8-nitro-4-chromanone derivative as a starting material, subjecting it to cyanation, dehydration, reduction, and sulfonylation to deviate a 4-cyano-8-alkylsulfonylamino)chroman derivative expressed by formula III, reacting the compound of formula III with hydrochloride acid gas in an alcohol solvent to convert it to the corresponding imidate and reacting the imidate with ethylenediame.