公开(公告)号：JP2008246401A

公开(公告)日：2008-10-16

申请号：JP2007092285

申请日：2007-03-30

Applicant: Ne Chemcat Corp ,  エヌ・イーケムキャット株式会社

Inventor： KANEDA KIYOOMI ,  UENO SHINJI

IPC: B01J31/26 ,  C07B53/00 ,  C07B61/00 ,  C07C51/353 ,  C07C62/24 ,  C07C67/347 ,  C07C69/757

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a solid catalyst for asymmetric Michael addition reaction easily separated from a product, enhanced in optical purity and prepared in an industrially inexpensive manner, and a manufacturing method of an optically active Michael addition product by the asymmetric Michael addition reaction of a 1, 3-dicarbonyl compound and an enone compound using the solid catalyst for asymmetric Michael addition reaction. SOLUTION: The solid catalyst for asymmetric Michael addition reaction is constituted by fixing lanthanide and an asymmetric carboxylic acid on a carrier comprising hydroxyapatite represented by the general formula (I): Ca 10-z (HPO 4 ) z (PO 4 ) 6-z (OH) 2-z *nH 2 O and/or fluoroapatite represented by the general formula (II): Ca 10-y (HPO 4 ) y (PO 4 ) 6-y F 2-y *nH 2 O both of which are preliminarily treated with the asymmetric carboxylic acid and produced by adding hydroxyapatite represented by the general formula (I) and/or fluoroapatite represented by the general formula (II), both of which are preliminarily treated with the asymmetric carboxylic acid to a solution, which is prepared by dissolving a salt of lanthanide and the asymmetric carboxylic acid in a solvent, to stirr the resulting solution to bond lanthanide to oxygen of phosphoric acid by the ion exchange with calcium of hydroxyapatite and/or fluoroapatite. The manufacturing method of the optically active Michael addition product is characterized in that the 1, 3-dicarbonyl compound and the enone compound are reacted in the presence of the solid catalyst for asymmetric Michael addition reaction. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：为了提供容易与产物分离的不对称迈克尔加成反应的固体催化剂，提高光学纯度并以工业上便宜的方式制备，以及通过不对称的光学活性迈克尔加成产物的制造方法 使用固体催化剂进行非对称迈克尔加成反应的1,3-二羰基化合物和烯酮化合物的迈克尔加成反应。 解决方案：用于不对称迈克尔加成反应的固体催化剂是通过将镧系元素和不对称羧酸固定在由通式（I）表示的羟基磷灰石的载体上构成的：HPO 4 ）ž（PO 4 ） 6-Z （OH） 2-Z 10-y（SBO 4）SB （PO 4 ） 6-y / SB> 2-y * nH SB 2 其通过将由不对称羧酸预先处理成溶液的通式（I）表示的羟基磷灰石和/或通式（II）表示的氟磷灰石进行预处理， 其通过将镧系元素和不对称羧酸的盐溶解在溶剂中来制备，以通过与h的钙离子交换而使所得溶液与镧系元素与磷酸的氧键合 羟基磷灰石和/或氟磷灰石。 光学活性迈克尔加成产物的制备方法的特征在于1,3-二羰基化合物和烯酮化合物在用于不对称迈克尔加成反应的固体催化剂存在下反应。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008246400A

公开(公告)日：2008-10-16

申请号：JP2007092284

申请日：2007-03-30

Applicant: Ne Chemcat Corp ,  エヌ・イーケムキャット株式会社

Inventor： KANEDA KIYOOMI ,  UENO SHINJI

IPC: B01J21/16 ,  B01J37/18 ,  C07B61/00 ,  C07C45/29 ,  C07C49/04 ,  C07C49/385 ,  C07C49/403 ,  C07C49/453

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a solid catalyst for the dehydrogenation reaction using an industrially inexpensive carrier but requiring no oxidizing agent and easily separated from a product, its manufacturing method and a manufacturing method of a saturated carbonyl compound by the dehydrogenation reaction of a saturated secondary alcohol compound using the catalyst. SOLUTION: The solid catalyst for alcohol dehydrogenation reaction contains carrier comprising hydrotalcite represented by the general formula: [Mg 8-z Al z (OH) 16 ] z+ [X n- z/n ]*mH 2 O and rhodium supported on the hydrotalcite carrier and is manufactured by adding hydrotalcite represented by the general formula to a solution of a rhodium compound and stirring the obtained mixture to subject the same to solid-liquid separation and drying treatment before reducing the dried mixture. The saturated carbonyl compound is manufactured by dehydrogenating the saturated secondary alcohol compound under a condition using no oxidizing agent in the presence of the solid catalyst for alcohol dehydrogenation reaction. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：为了提供使用工业上廉价的载体但不需要氧化剂并且容易与产物分离的脱氢反应的固体催化剂，其制备方法和通过脱氢反应的饱和羰基化合物的制备方法 的饱和仲醇化合物。 解决方案：用于醇脱氢反应的固体催化剂包含由以下通式表示的水滑石的载体：[Mg SB 8（OH）SB 16 ] z + [X n - z / n ] * 水滑石载体，通过将由通式表示的水滑石添加到铑化合物的溶液中并搅拌所得混合物以在还原干燥混合物之前进行固液分离和干燥处理来制造。 在醇脱氢反应的固体催化剂的存在下，在不使用氧化剂的条件下使饱和仲醇化合物脱氢来制造饱和羰基化合物。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2008246399A

公开(公告)日：2008-10-16

申请号：JP2007092283

申请日：2007-03-30

Applicant: Ne Chemcat Corp ,  エヌ・イーケムキャット株式会社

Inventor： KANEDA KIYOOMI ,  UENO SHINJI

IPC: B01J23/58 ,  C07B41/06 ,  C07B61/00 ,  C07C47/228 ,  C07C47/23 ,  C07C49/213 ,  C07C49/215 ,  C07C49/233 ,  C07C49/255 ,  C07C49/657 ,  C07C255/19 ,  C07D307/54 ,  C07D309/30

CPC classification number: Y02P20/52

Abstract: PROBLEM TO BE SOLVED: To provide a catalyst which is a solid catalyst facilitating the separation of a target product, easily prepared and used for manufacturing a carbon-carbon bond product by the 1,4-addition reaction of aromatic boronic acid and an α, β-unsaturated carbonyl compound or an α, β-unsaturated nitrile compound. SOLUTION: The catalyst is composed of a carrier comprising hydrotalcite represented by the general formula: [Mg 8-z Al z (OH) 16 ] z+ [X n- z/n ]*mH 2 O and rhodium supported on the hydrotalcite carrier and used for the addition reaction of aromatic boronic acid and the α, β-unsaturated carbonyl compound or an α, β-unsaturated nitrile compound. The carbon-carbon bond product is produced by the addition reaction of aromatic boronic acid and the α, β-unsaturated carbonyl compound or an α, β-unsaturated nitrile compound in the presence of the solid catalyst for addition reaction. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供一种催化剂，其是促进目标产物分离的固体催化剂，容易制备并用于制备碳 - 碳键产物，通过芳香族硼酸的1,4-加成反应和 α，β-不饱和羰基化合物或α，β-不饱和腈化合物。 解决方案：催化剂由包含由以下通式表示的水滑石的载体组成：[Mg 3 S 8 -Z] SB>] z + [X n - z / n ] * mH 2和支撑在水滑石上的铑 载体，用于芳香族硼酸和α，β-不饱和羰基化合物或α，β-不饱和腈化合物的加成反应。 碳 - 碳键产物是通过芳族硼酸和α，β-不饱和羰基化合物或α，β-不饱和腈化合物在用于加成反应的固体催化剂存在下的加成反应制备的。 版权所有（C）2009，JPO＆INPIT