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公开(公告)号：JP2012143250A
公开(公告)日：2012-08-02
申请号：JP2012106130
申请日：2012-05-07
申请人： Novo Nordisk As , ノボ ノルデイスク エイ エス
发明人： DE FREES SHAWN , ZOPF DAVID , BAYER ROBERT , BOWE CARYN , HAKES DAVID , CHEN XI
IPC分类号： C12N15/09 , C12P21/02 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61P1/16 , A61P3/10 , A61P5/10 , A61P7/04 , A61P7/06 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H19/10 , C07K1/00 , C07K1/107 , C07K1/13 , C07K2/00 , C07K9/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/715 , C07K14/755 , C07K14/81 , C07K16/08 , C07K16/18 , C07K16/24 , C07K16/28 , C12N9/16 , C12N9/22 , C12N9/26 , C12N9/42 , C12N9/64 , C12N9/72 , C12P19/26 , C12P21/00 , C12P21/06 , C12P21/08
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073
摘要： PROBLEM TO BE SOLVED: To provide more effective granulocyte colony stimulating factor (G-CSF).SOLUTION: A method for covalently bonding a modifying group having a glycosyl group to a G-CSF factor and a covalent conjugate obtained by the method are provided.
摘要翻译： 要解决的问题：提供更有效的粒细胞集落刺激因子（G-CSF）。 解决方案：提供了通过该方法共价键合具有糖基的修饰基团与G-CSF因子和共价缀合物的方法。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2014087370A
公开(公告)日：2014-05-15
申请号：JP2014013799
申请日：2014-01-28
申请人： Novo Nordisk As , ノボ ノルデイスク エイ エス
发明人： DE FREES SHAWN , ZOPF DAVID , BAYER ROBERT , BOWE CARYN , HAKES DAVID , CHEN XI
IPC分类号： C12N15/09 , C12P21/02 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61P1/16 , A61P3/10 , A61P5/10 , A61P7/04 , A61P7/06 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H19/10 , C07K1/00 , C07K1/107 , C07K1/13 , C07K9/00 , C07K14/00 , C07K14/47 , C07K14/475 , C07K14/505 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/575 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/755 , C07K14/81 , C07K16/00 , C07K16/08 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/46 , C12N9/16 , C12N9/22 , C12N9/26 , C12N9/42 , C12N9/64 , C12N9/72 , C12P19/26 , C12P21/00 , C12P21/06 , C12P21/08
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073
摘要： PROBLEM TO BE SOLVED: To provide a more effective G-CSF factor.SOLUTION: Provided are a method of covalently attaching a modifying group having a glycosyl group to a G-CSF factor, and a conjugate obtained by the method.
摘要翻译： 要解决的问题：提供更有效的G-CSF因子。解决方案：提供将具有糖基的修饰基团共价连接到G-CSF因子的方法和通过该方法获得的缀合物的方法。
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公开(公告)号：JP2010120954A
公开(公告)日：2010-06-03
申请号：JP2010024516
申请日：2010-02-05
申请人： Novo Nordisk As , ノボ ノルデイスク エイ エス
发明人： DE FREES SHAWN , ZOPF DAVID , BAYER ROBERT , BOWE CARYN , HAKES DAVID , CHEN XI
IPC分类号： C07K14/535 , C12N15/09 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K45/00 , A61K47/48 , A61P1/16 , A61P3/10 , A61P5/10 , A61P7/02 , A61P7/04 , A61P7/06 , A61P13/00 , A61P15/00 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07H19/10 , C07K1/00 , C07K1/107 , C07K1/13 , C07K9/00 , C07K14/00 , C07K14/02 , C07K14/46 , C07K14/47 , C07K14/505 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/755 , C07K14/81 , C07K16/08 , C07K16/18 , C07K16/24 , C07K16/28 , C12N9/16 , C12N9/22 , C12N9/26 , C12N9/42 , C12N9/64 , C12N9/72 , C12P19/26 , C12P21/00 , C12P21/02 , C12P21/06 , C12P21/08
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073
摘要： PROBLEM TO BE SOLVED: To provide a more effective G-CSF factor capable of producing a glycosyl-modified peptide in an industrial scale. SOLUTION: A method for covalently bonding a modifying group having a glycosyl group to a G-CSF factor, and a covalent conjugate obtained by the method are provided. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 待解决的问题：提供能够以工业规模生产糖基修饰的肽的更有效的G-CSF因子。 解决方案：提供了将通过糖基分解的修饰基团与G-CSF因子共价键合的方法和通过该方法得到的共价结合体。 版权所有（C）2010，JPO＆INPIT
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