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    Composition and method for treating lung cancer
    2.
    发明专利
    Composition and method for treating lung cancer 审中-公开
    用于治疗肺癌的组合物和方法

    公开(公告)号：JP2011078418A

    公开(公告)日：2011-04-21

    申请号：JP2010248037

    申请日：2010-11-05

    申请人： Oncotherapy Science Ltd ,  オンコセラピー・サイエンス株式会社

    发明人： NAKAMURA YUSUKE ,  DAIGO YATARO ,  NAKAZURU SHUICHI

    IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K48/00 ,  A61P35/00 ,  A61P35/02 ,  C12N15/09 ,  G01N33/574

    CPC分类号： C12N15/113 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/53 ,  G01N33/57423

    摘要： PROBLEM TO BE SOLVED: To provide a composition for treatment of lung cancer and a method for inhibiting growth of a cell.
    SOLUTION: A double-stranded molecule includes a sense strand and an antisense strand, wherein the sense strand includes a ribonucleotide sequence corresponding to a target sequence, the antisense strand comprises a ribonucleotide sequence which is complementary to the sense strand, and the sense and the antisense strands hybridize to each other to form a double-stranded molecule. Expression of a gene is inhibited by introduction of the double-stranded molecule into a cell which expresses a PKP3, CDCA1, CDCA8, DLX5, URLC11, or NPTX1 gene. The method of treating or preventing lung cancer in a subject includes administering to the subject a composition comprising a small interfering RNA (siRNA) for inhibiting the expression of the PKP3, CDCA1, CDCA8, DLX5, URLC11 or NPTX1 gene.
    COPYRIGHT: (C)2011,JPO&INPIT

    摘要翻译： 待解决的问题：提供用于治疗肺癌的组合物和抑制细胞生长的方法。 解决方案：双链分子包括有义链和反义链，其中有义链包括对应于靶序列的核糖核苷酸序列，反义链包含与有义链互补的核糖核苷酸序列，并且 正义和反义链彼此杂交以形成双链分子。 通过将双链分子引入表达PKP3，CDCA1，CDCA8，DLX5，URLC11或NPTX1基因的细胞中来抑制基因的表达。 治疗或预防受试者肺癌的方法包括向受试者施用包含用于抑制PKP3，CDCA1，CDCA8，DLX5，URLC11或NPTX1基因表达的小干扰RNA（siRNA）的组合物。 版权所有（C）2011，JPO＆INPIT

    Method for diagnosing non-small cell lung cancer
    4.
    发明专利
    Method for diagnosing non-small cell lung cancer 审中-公开
    用于诊断非小细胞肺癌的方法

    公开(公告)号：JP2012125247A

    公开(公告)日：2012-07-05

    申请号：JP2012003039

    申请日：2012-01-11

    申请人： Oncotherapy Science Ltd ,  オンコセラピー・サイエンス株式会社

    发明人： NAKAMURA YUSUKE ,  DAIGO YATARO ,  NAKAZURU SHUICHI

    IPC分类号： C12Q1/68 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  C07K14/47 ,  C07K16/18 ,  C12M1/02 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/113 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574 ,  G01N37/00

    CPC分类号： G01N33/57423 ,  A61K31/7088 ,  C07K14/47 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/50

    摘要： PROBLEM TO BE SOLVED: To provide a method for detecting non-small cell lung cancer using differentially expressed genes, and a method for identifying a compound for treating and preventing non-small cell lung cancer.SOLUTION: This invention relates to a method for diagnosing non-small cell lung cancer or factors of developing non-small cell lung cancer in a biological sample derived from a subject. According to the method, it is detected that the subject is affected with the non-small cell lung cancer or that the subject has a risk of developing the non-small cell lung cancer based on the increase or decrease of a level relative to a normal collation level of the genes. The invention further relates to a method for identifying a compound which inhibits the expression or activity of non-small cell lung cancer-related genes including: (1) a step of bringing test cells expressing the non-small cell lung cancer-related genes into contact with a test compound; (2) a step of detecting the level of expression of the non-small cell lung cancer-related genes; and (3) a step of determining a compound suppressing the level of expression relative to the normal collation level as a factor of inhibiting the non-small cell lung cancer-related genes.

    摘要翻译： 待解决的问题：提供使用差异表达基因检测非小细胞肺癌的方法，以及鉴定用于治疗和预防非小细胞肺癌的化合物的方法。 解决方案：本发明涉及一种用于诊断非小细胞肺癌的方法或来自受试者的生物样品中发展中的非小细胞肺癌的因素。 根据该方法，检测到受试者受到非小细胞肺癌的影响，或者受试者具有基于相对于正常人的水平的增加或减少而发展非小细胞肺癌的风险 基因的整理水平。 本发明还涉及一种鉴定抑制非小细胞肺癌相关基因表达或活性的化合物的方法，包括：（1）使表达非小细胞肺癌相关基因的测试细胞进入 与试验化合物接触; （2）检测非小细胞肺癌相关基因表达水平的步骤; 和（3）作为抑制非小细胞肺癌相关基因的因子，测定抑制相对于正常对照水平的表达水平的化合物的步骤。 版权所有（C）2012，JPO＆INPIT

    Peptide vaccine for lung cancer expressing ttk, urlc10 or koc1 polypeptides
    5.
    发明专利
    Peptide vaccine for lung cancer expressing ttk, urlc10 or koc1 polypeptides 有权
    肺癌用于表达TTK，URLC10或KOC1多肽的肺癌疫苗

    公开(公告)号：JP2009173660A

    公开(公告)日：2009-08-06

    申请号：JP2009058798

    申请日：2009-03-12

    申请人： Oncotherapy Science Ltd ,  オンコセラピー・サイエンス株式会社

    发明人： TAWARA HIDEAKI ,  TSUNODA TAKUYA ,  NAKAMURA YUSUKE ,  DAIGO YATARO ,  NAKAZURU SHUICHI

    IPC分类号： C07K7/06 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C07K7/08 ,  C12N5/06 ,  C12N15/09

    CPC分类号： C12N9/1211 ,  C12Q1/6886

    摘要： PROBLEM TO BE SOLVED: To provide immunogenic peptides which are specifically upward controlled with tumor cells of lung cancer tissues, are useful for killing the tumor cells, and are originated from TTK, URLC10 or KOC1. SOLUTION: There are provided: peptides comprising specific amino acid sequences; as well as peptides comprising the above amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility. Medicines for treating or preventing tumors comprises these peptides. The peptides can also be used as vaccines. COPYRIGHT: (C)2009,JPO&INPIT

    摘要翻译： 要解决的问题：为了提供特异性向上受到肺癌组织的肿瘤细胞控制的免疫原性肽，可用于杀死肿瘤细胞，并且起源于TTK，URLC10或KOC1。 提供：提供了包含特定氨基酸序列的肽; 以及包含上述氨基酸序列的肽，其中1,2或几个氨基酸被取代，缺失或添加，并具有细胞毒性T细胞诱导性。 用于治疗或预防肿瘤的药物包括这些肽。 肽也可以用作疫苗。 版权所有（C）2009，JPO＆INPIT

    Method for diagnosing non-small cell lung cancer
    8.
    发明专利
    Method for diagnosing non-small cell lung cancer 有权
    用于诊断非小细胞肺癌的方法

    公开(公告)号：JP2009240313A

    公开(公告)日：2009-10-22

    申请号：JP2009138122

    申请日：2009-06-09

    申请人： Oncotherapy Science Ltd ,  オンコセラピー・サイエンス株式会社

    发明人： NAKAMURA YUSUKE ,  DAIGO YATARO ,  NAKAZURU SHUICHI

    IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/113 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50

    CPC分类号： G01N33/57423 ,  A61K31/7088 ,  C07K14/47 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/50

    摘要： PROBLEM TO BE SOLVED: To provide a method for detecting non-small cell lung cancer using differentially expressed genes, and to provide a method for identifying a compound for treating and preventing the non-small cell lung cancer. SOLUTION: The method for diagnosing the non-small cell lung cancer or a predisposition to developing the non-small lung cancer in a biological sample derived from a subject is provided. In the method, an increase or a decrease of the level compared to a normal control level of the gene indicates that the subject suffers from or is at a risk of developing the non-small cell lung cancer. The method for identifying the compound that inhibits the expression or the activity of the non-small cell lung cancer-associated gene comprises (1) a step of bringing a test cell expressing the non-small cell lung cancer-associated gene into contact with a test compound; (2) a step of detecting the expression level of the non-small cell lung cancer-associated gene; and (3) a step of determining the compound that suppresses the expression level compared to the normal control level of the gene as an inhibitor of the non-small cell lung cancer-associated gene. COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译： 待解决的问题：提供使用差异表达基因检测非小细胞肺癌的方法，并提供鉴定用于治疗和预防非小细胞肺癌的化合物的方法。 提供了用于诊断非小细胞肺癌的方法或从衍生自受试者的生物样品中发展非小细胞肺癌的倾向。 在该方法中，与基因的正常对照水平相比，水平的增加或降低表明受试者患有或处于发展非小细胞肺癌的风险中。 用于鉴定抑制非小细胞肺癌相关基因的表达或活性的化合物的方法包括：（1）使表达非小细胞肺癌相关基因的测试细胞与 试验化合物; （2）检测非小细胞肺癌相关基因的表达水平的步骤; 和（3）与作为非小细胞肺癌相关基因的抑制剂的基因的正常对照水平相比，测定抑制表达水平的化合物的步骤。 版权所有（C）2010，JPO＆INPIT