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公开(公告)号：JP2014193190A
公开(公告)日：2014-10-09
申请号：JP2014138644
申请日：2014-07-04
Inventor： NOGUCHI MAKOTO
Abstract: PROBLEM TO BE SOLVED: To provide a promoter capable of easily undergoing a culture to a spheroid form.SOLUTION: A spheroid-forming promoter is characterized by being obtained by using a body fluid present in the trunk or a body fluid collected from the liver of cuttlefish or octopus among cephalopoda. The body fluid may be collected by squeezing or centrifuging, or by dripping through freeze-thaw technique.
Abstract translation: 要解决的问题：提供能够容易地经历培养至球状体的促进剂。解决方案：球形成形促进剂的特征在于通过使用存在于树干中的体液或从肝脏收集的体液获得 头鱼中的墨鱼或章鱼。 体液可以通过挤压或离心收集，或通过冻融技术滴入。
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公开(公告)号：JP2007314458A
公开(公告)日：2007-12-06
申请号：JP2006145160
申请日：2006-05-25
Inventor： TAKAHASHI YUSUKE , NOGUCHI MAKOTO
Abstract: PROBLEM TO BE SOLVED: To provide an extraction method capable of simply obtaining a collagen having high quality in good yield.
SOLUTION: A crude collagen (2.5g) obtained from scales is weighed and 25 ml of 30% aqueous solution of the hydrogen peroxide is added to the weighed crude collagen and the mixture is allowed to stand for 16 hr. at a room temperature of 20°C to 25°C. Then, 200 ml of 0.02N acetic acid is added to the mixture of aqueous hydrogen peroxide with the crude collagen and the mixture is allowed to stand for 72 hr. in this state. Then, the mixture of the aqueous hydrogen peroxide with the crude collagen and the acetic acid is subjected to centrifugal separation for 10 min in 1.000 rpm number of revolutions to remove an insoluble ingredient. Further, the mixture is dialyzed to remove a low-molecular weight component such as hydrogen peroxide and acetic acid, and freeze-drying of the treated mixture is carried out to provide 1.53g collagen in 61.2% yield.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 待解决的问题：提供能够简单地以良好的产率获得高质量的胶原的提取方法。
解决方案：称量从鳞片获得的粗胶原（2.5g），并将25ml 30％过氧化氢水溶液加入到称重的粗胶原中，并将混合物静置16小时。 在室温为20℃至25℃。 然后，将200ml的0.02N乙酸加入过氧化氢水溶液与粗胶原的混合物中，并使混合物静置72小时。 在这个状态。 然后，将过氧化氢水溶液与粗胶原和乙酸的混合物以1.000rpm转数进行离心分离10分钟以除去不溶成分。 此外，将混合物透析以除去低分子量组分如过氧化氢和乙酸，并进行冷冻干燥处理的混合物，得到61.3％胶原蛋白，产率为61.2％。 版权所有（C）2008，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2010013440A
公开(公告)日：2010-01-21
申请号：JP2009125456
申请日：2009-05-25
Applicant: Tottori Institute Of Industrial Technology , Tottori Univ , 国立大学法人鳥取大学 , 地方独立行政法人鳥取県産業技術センター
Inventor： KUDOME ICHIRO , SHIRAYOSHI YASUAKI , TAKEYA HIROYUKI , TOYOSHIMA RYOTA , NOGUCHI MAKOTO , UMEBAYASHI MOTOHIRO
IPC: A61K31/202 , A61K31/138 , A61K45/00 , A61P9/00 , A61P9/06 , A61P43/00
Abstract: PROBLEM TO BE SOLVED: To provide an atrial remodeling inhibitor for prophylaxis and therapy of chronic atrial fibrillation, wherein Kv1.5 protein that is an ion channel is reduced to make an antiarrhythmic drug ineffective by the atrial remodeling.
SOLUTION: The atrial remodeling inhibitor includes EPA (eicosapentaenoic acid) in a low dose for increasing the Kv1.5 protein in cardiac muscle, wherein the EPA is orally and chronically administered to a patient. The atrial remodeling inhibitor can prevent even a decrease in cardiac contractility, thrombus, embolism, or cerebral apoplexy etc., caused by the atrial fibrillation.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 要解决的问题：提供用于预防和治疗慢性心房颤动的心房重塑抑制剂，其中作为离子通道的Kv1.5蛋白质被还原以使抗心律不齐药物由于心房重构无效。 解决方案：心房重塑抑制剂包括低剂量的EPA（二十碳五烯酸），用于增加心肌中的Kv1.5蛋白质，其中EPA被口服和长期施用于患者。 心房重塑抑制剂可以预防房颤引起的心脏收缩力，血栓，栓塞或脑中风等的降低。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2009219430A
公开(公告)日：2009-10-01
申请号：JP2008067178
申请日：2008-03-17
Applicant: Kanda Giko:Kk , Tottori Institute Of Industrial Technology , Tottori Univ , 国立大学法人鳥取大学 , 地方独立行政法人鳥取県産業技術センター , 有限会社カンダ技工
Inventor： OSHIRO TAKASHI , IZUMI YOSHIKAZU , NAKAYAMA HAJIME , NOGUCHI MAKOTO , TAKAHASHI YUSUKE
IPC: C12P21/06 , A23J3/04 , A23J3/34 , A61K8/65 , A61K38/00 , A61K38/17 , A61P17/16 , A61P19/02 , A61Q19/00 , C07K14/78
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a collagen peptide which produces a large amount of an uncolored collagen peptide in a short time. SOLUTION: The method for producing a collagen peptide suppressed in coloration or uncolored, includes heating a collagen-containing raw material or collagen in the presence of hydrogen peroxide. A collagen-containing raw material or collagen is heated and treated with a proteinase before the hydrogen peroxide treatment to obtain a collagen peptide in a shorter time. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 待解决的问题：提供一种在短时间内产生大量未着色胶原肽的胶原肽的制备方法。 抑制着色或未着色的胶原肽的制造方法包括在过氧化氢的存在下加热含胶原的原料或胶原。 在过氧化氢处理之前用含蛋白酶的方法加热含有胶原蛋白的原料或胶原，在较短时间内得到胶原肽。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2011062129A
公开(公告)日：2011-03-31
申请号：JP2009215142
申请日：2009-09-17
Inventor： NOGUCHI MAKOTO
Abstract: PROBLEM TO BE SOLVED: To provide a promoter capable of easily undergoing a culture to a spheroid form.
SOLUTION: The spheroid-forming promoter is characterized by being obtained by using the body fluid of predetermined fish having mucosal body skin, wherein the body fluid is collected from the sites ranging from the skin to muscular tissue. It is preferable that the body fluid to be used is Allolepis hollandi, Lycodes tanakai Jordan and Thompson or flatfish one. Another version of the promoter is characterized by being obtained by using the body fluid present on the inner surface of the trunk of cuttlefish or octopus, or collected from the liver thereof; wherein the body fluid may be collected by squeezing or centrifuging the relevant fish, cuttlefish or octopus or by dripping through freeze-thaw technique.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 待解决的问题：提供能够容易地进行培养的促进剂以使球状体形成。 解决方案：球状体形成促进剂的特征在于通过使用具有粘膜体皮肤的预定鱼的体液获得，其中从皮肤到肌肉组织的位置收集体液。 优选使用的体液是Allolepis hollandi，Lycodes tanakai Jordan和Thompson或鲽鱼。 其特征在于通过使用存在于墨鱼或章鱼的内表面上的体液或从其肝脏收集的体液; 其中，可以通过挤压或离心相关鱼，墨鱼或章鱼或通过冻融技术滴入来收集体液。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2008011818A
公开(公告)日：2008-01-24
申请号：JP2006188411
申请日：2006-07-07
Applicant: Fujicco Co Ltd , Fujicco Foods Kk , Tottori Institute Of Industrial Technology , フジッコフーズ株式会社 , フジッコ株式会社 , 地方独立行政法人鳥取県産業技術センター
Inventor： SEGAWA YUKIHIDE , NOGUCHI MAKOTO , ARIFUKU ICHIRO
Abstract: PROBLEM TO BE SOLVED: To provide a new method for producing nata de coco with the intention for preventing microbial tainting and for space saving and production process shortening. SOLUTION: The method for producing nata de coco is provided with a seed culture step as stirring culture, and microbial tainting is prevented in the seed culture step, thus saving a working space. Cellulose lumps developed in a seed medium are removed by either one process among the following processes:(1) seed medium filtration; (2) a seed culture is made using a cellulase-containing seed medium; and (3) cellulase is added to the seed medium after completing the seed culture. By removing cellulose lumps in the seed medium, cellulose lumps are prevented from mixing into the culture medium, enabling nata de coco sheet surface to be smoothed. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 要解决的问题：为了提供一种新的防止微生物污染和节省空间和生产过程缩短的方法来提供新的方法。 解决方案：提供了一种用于搅拌培养的种子培养步骤，在种子培养步骤中防止微生物污染，从而节省了工作空间。 在种子培养基中培养的纤维素块通过以下过程中的任一种方法除去：（1）种子培养基过滤; （2）使用含有纤维素酶的种子培养基进行种子培养; 并且（3）在完成种子培养后将纤维素酶加入到种子培养基中。 通过除去种子培养基中的纤维素块，可以防止纤维素块混入培养基中，从而能使平滑的花椰菜片表面变得平滑。 版权所有（C）2008，JPO＆INPIT
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7.发明专利Volume reduction extraction method of glycosaminoglycan and generation method of proteoglycan-containing precipitation 有权谷氨酰胺凝胶的体积减少提取方法和含有蛋白酶的沉淀的产生方法
公开(公告)号：JP2010124811A
公开(公告)日：2010-06-10
申请号：JP2008306264
申请日：2008-12-01
Applicant: Daimatsu:Kk , Tottori Institute Of Industrial Technology , 地方独立行政法人鳥取県産業技術センター , 株式会社 ダイマツ
Inventor： WATABE SHINYA , NOGUCHI MAKOTO , ARIFUKU ICHIRO , TAKAHASHI YUSUKE , UMEBAYASHI MOTOHIRO
Abstract: PROBLEM TO BE SOLVED: To provide a technology increasing workability and effectively extracting and isolating glycosaminoglycan and proteoglycan.
SOLUTION: There is provided a volume reduction extraction method of glycosaminoglycan, which comprises adding an alkaline aqueous solution to tissues derived from a living body to obtain an extraction liquid containing glycosaminoglycan, adding an acidic aqueous solution to the extraction liquid to generate precipitation to reduce volume, and exposing the precipitation to an acidic aqueous solution containing inorganic salts and adjusted its pH to be almost the pH in generation of the precipitation so as to elute glycosaminoglycan in the aqueous solution.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 要解决的问题：提供技术增加的可操作性并有效提取和分离糖胺聚糖和蛋白多糖。 提供了一种糖胺聚糖的体积缩小提取方法，其包括将碱性水溶液添加到来自活体的组织中，得到含有糖胺聚糖的提取液，向所述提取液中添加酸性水溶液以产生沉淀 降低体积，并将沉淀物暴露于含有无机盐的酸性水溶液中，并将其pH调节至几乎为沉淀生成时的pH值，从而在水溶液中洗脱糖胺聚糖。 版权所有（C）2010，JPO＆INPIT
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