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公开(公告)号:JP2009209150A
公开(公告)日:2009-09-17
申请号:JP2009141638
申请日:2009-05-25
发明人: LAZAR GREGORY ALAN , CHIRINO ARTHUR J , DANG WEI , DESJARLAIS JOHN RUDOLPH , DOBERSTEIN STEPHEN KOHL , HAYES ROBERT J , KARKI SHER BAHADUR , VAFA OMID
IPC分类号: C07K16/28 , A61K38/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/10 , A61P3/14 , A61P7/00 , A61P9/04 , A61P9/10 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07K16/00 , C07K16/32 , C12N15/09
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K2317/52
摘要: PROBLEM TO BE SOLVED: To provide Fc variants optimized in a number of therapy-associated characteristics. SOLUTION: Optimized Fc variants, methods for generating them, and antibodies and Fc fusions comprising the optimized Fc variants are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译: 要解决的问题:提供在许多治疗相关特征中优化的Fc变体。 提供了优化的Fc变体,产生它们的方法,以及包含优化的Fc变体的抗体和Fc融合体。 版权所有(C)2009,JPO&INPIT
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公开(公告)号:JP2009203237A
公开(公告)日:2009-09-10
申请号:JP2009141637
申请日:2009-05-25
发明人: LAZAR GREGORY ALAN , CHIRINO ARTHUR J , DANG WEI , DESJARLAIS JOHN RUDOLPH , DOBERSTEIN STEPHEN KOHL , HAYES ROBERT J , KARKI SHER BAHADUR , VAFA OMID
IPC分类号: C07K16/30 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/32 , C07K16/46 , C12N15/09
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K2317/34 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/94
摘要: PROBLEM TO BE SOLVED: To provide Fc variants optimized to many treatment-related characteristics. SOLUTION: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising the optimized Fc variants. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译: 要解决的问题:提供针对许多治疗相关特征优化的Fc变体。 解决方案:本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。 版权所有(C)2009,JPO&INPIT
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公开(公告)号:JP2011188869A
公开(公告)日:2011-09-29
申请号:JP2011136557
申请日:2011-06-20
发明人: LAZAR GREGORY ALAN , DANG WEI , DESJARLAIS JOHN R , KARKI SHER BAHADUR , VAFA OMID , HAYES ROBERT
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/2863 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: PROBLEM TO BE SOLVED: To provide Fc variants optimized for a number of therapeutically relevant properties. SOLUTION: The present invention relates to the optimized Fc variants, methods for their generation, Fc polypeptides comprising the optimized Fc variants, and methods for using the optimized Fc variants. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译: 待解决的问题:提供针对多种治疗相关性质优化的Fc变体。 解决方案:本发明涉及优化的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。 版权所有(C)2011,JPO&INPIT
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