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31 条记录 (耗时 0.017 秒)

    Preparation of optically active mercaptocarboxylic acid
    4.
    发明专利
    Preparation of optically active mercaptocarboxylic acid 失效
    光学活性磷酰胆酸的制备

    公开(公告)号：JPS5738768A

    公开(公告)日：1982-03-03

    申请号：JP11505380

    申请日：1980-08-20

    申请人： Kanegafuchi Chem Ind Co Ltd

    发明人： OOHASHI TAKEHISA ,  SHIMAZAKI MASAMI ,  NOMURA KENJI ,  SUGA KAZUNORI ,  WATANABE KIYOSHI

    IPC分类号： C07B53/00 ,  C07B31/00 ,  C07C53/19 ,  C07C53/50 ,  C07C67/00 ,  C07C313/00 ,  C07C319/02 ,  C07C319/14 ,  C07C323/52

    CPC分类号： C07C53/50 ,  C07C53/19 ,  C07C323/00

    摘要： PURPOSE: To obtain the titled compound useful as a raw material for a hypotensive agent, etc. in high purity and yield economically, by reacting a specific optically active halogenous compound with a hydrosulfide formed from hydrogen sulfide and a base, and hydrolyzing the resultant product.
    CONSTITUTION: An optically active halogenous compound, e.g. β-D-chloroisobutyric acid, expressed by formula I [X is halogen; n is an integer 1W3; R
    1 is H or 1W 4C lower alkyl; R
    2 is H or 1W4C lower alkyl (however except H when R
    1 is H); R
    3 is carboxyl or a group capable of forming carboxyl group] is reacted with a hydrosulfide prepared from hydrogen sulfide and a base, e.g. sodium hydrosulfide. In case R
    3 cannot be converted into the carboxyl group, the intermediate product is further hydrolyzed to give the aimed compound expressed by formula II.
    COPYRIGHT: (C)1982,JPO&Japio

    摘要翻译： 目的：通过使特定的光学活性卤化合物与硫化氢和碱形成的氢硫化物反应，得到经济上高纯度和低收率的低血压药原料等有用的标题化合物，并水解所得产物 。 构成：光学活性的卤素化合物，例如 由式I表示的β-D-氯异丁酸[X是卤素; n为整数1-3; R1是H或1-4位低级烷基; R2为H或1-4C的低级烷基（但当R 1为H时为H）; R3是羧基或能够形成羧基的基团]与由硫化氢和碱制备的氢硫化物反应。 氢硫化钠。 在不能转化为羧基的情况下，中间产物进一步水解，得到式II表示的目标化合物。

    Method for producing 3,3,3-trifluoropropionic acid chloride
    9.
    发明专利
    Method for producing 3,3,3-trifluoropropionic acid chloride 有权
    制备3,3,3-三氟丙酸氯化物的方法

    公开(公告)号：JP2007302648A

    公开(公告)日：2007-11-22

    申请号：JP2006205206

    申请日：2006-07-27

    申请人： Central Glass Co Ltd ,  セントラル硝子株式会社

    发明人： KOMATA TAKEO ,  HOSOI TAKESHI ,  AKIBA SHINYA

    IPC分类号： C07C51/58 ,  C07C51/04 ,  C07C53/21 ,  C07C53/50

    CPC分类号： C07C51/60 ,  C07C53/50

    摘要： PROBLEM TO BE SOLVED: To provide a method for producing 3,3,3-trifluoropropionic acid chloride, on an industrial scale, useful as an intermediate for a medicine and an agrochemical or a production raw material or a synthetic intermediate for a functional material such as a fluorine-containing polymer, etc.
    SOLUTION: 3,3,3-Trifluoropropionic acid chloride is obtained in high selectivity by chlorinating 3,3,3-trifluoroproionaldehyde with a chlorinating agent selected from chlorine, sulfuryl chloride and an organic N-chloro compound under a specific condition.
    COPYRIGHT: (C)2008,JPO&INPIT

    摘要翻译： 待解决的问题：提供一种工业规模生产3,3,3-三氟丙酰氯的方法，其用作药物和农用化学品的中间体或生产原料或合成中间体 功能材料如含氟聚合物等。解决方案：通过用选自氯，磺酰氯的氯化剂氯化3,3,3-三氟丙醛，以高选择性获得3,3,3-三氟丙酰氯 和在特定条件下的有机N-氯化合物。 版权所有（C）2008，JPO＆INPIT