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公开(公告)号:JP2006182783A
公开(公告)日:2006-07-13
申请号:JP2006020169
申请日:2006-01-30
申请人: Research Corp Technologies Inc , リサーチ コーポレイション テクノロジーズ,インコーポレイテッドResearch Corporation Technologies, Inc.
IPC分类号: C07K16/18 , G01N33/53 , A61K38/00 , A61K38/20 , A61K39/395 , A61P31/12 , A61P37/06 , C07K14/54 , C07K14/73 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号: A61K38/2013 , A61K2039/505 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K16/244 , Y10S514/885 , A61K2300/00
摘要: PROBLEM TO BE SOLVED: To provide an antibody specific to a fragment of a lymphocyte chemical inducible factor (LCF) polypeptide shown by a particular sequence.
SOLUTION: The antibody specific to the LCF polypeptide shown by a particular sequence that neutralizes biological activity of the LCF polypeptide is provided. The antibody can control LCF-CD4 interaction and carry out screening of a candidate LCF agonist or an antagonist. The antibody is useful to stimulate propagation of CD4
+ T cells in mammals.
COPYRIGHT: (C)2006,JPO&NCIPI摘要翻译: 待解决的问题:提供对特定序列所示的淋巴细胞化学诱导因子(LCF)多肽的片段特异的抗体。 解决方案:提供了中和LCF多肽的生物学活性的特定序列显示的LCF多肽特异性抗体。 抗体可以控制LCF-CD4相互作用并进行候选LCF激动剂或拮抗剂的筛选。 该抗体可用于刺激哺乳动物中CD4 + SP + T细胞的繁殖。 版权所有(C)2006,JPO&NCIPI
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公开(公告)号:JP2009149651A
公开(公告)日:2009-07-09
申请号:JP2008330880
申请日:2008-12-25
IPC分类号: C07K14/52 , G01N33/53 , A61K38/00 , A61K38/20 , A61K39/395 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P31/12 , A61P37/06 , C07K14/54 , C07K14/73 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号: A61K38/2013 , A61K2039/505 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K16/244 , Y10S514/885 , A61K2300/00
摘要: PROBLEM TO BE SOLVED: To provide a method for searching a lymphocyte chemoattractant factor and a method for using the same. SOLUTION: The purified DNA encoding a LCF and the recombinant protein expressed from such DNA are disclosed. The LCF fragment or analog exhibits a LCF agonist or antagonist activity. The method for suppressing a LCF-CD4 interaction and the method for screening a candidate LCF agonist or antagonist are provided. The composition and a method useful for stimulating proliferation of CD4 + T-cell in a mammal are also provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译: 待解决的问题:提供一种搜索淋巴细胞趋化因子的方法及其使用方法。 解决方案:公开了编码LCF的纯化DNA和由此DNA表达的重组蛋白。 LCF片段或类似物显示LCF激动剂或拮抗剂活性。 提供了抑制LCF-CD4相互作用的方法和筛选候选LCF激动剂或拮抗剂的方法。 还提供了用于刺激哺乳动物CD4 + T细胞增殖的组合物和方法。 版权所有(C)2009,JPO&INPIT
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公开(公告)号:JP4279289B2
公开(公告)日:2009-06-17
申请号:JP2006020169
申请日:2006-01-30
IPC分类号: C07K16/18 , G01N33/53 , A61K38/00 , A61K38/20 , A61K39/395 , A61P31/12 , C07K14/54 , C07K14/73 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号: A61K38/2013 , A61K2039/505 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K16/244 , Y10S514/885 , A61K2300/00
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公开(公告)号:JP2014516913A
公开(公告)日:2014-07-17
申请号:JP2013538955
申请日:2011-11-11
申请人: シーダース シナイ メディカル センター
发明人: チュウ、カン−ユー , ケイ シャー、プレディマン
IPC分类号: A61K39/00 , A61K38/00 , A61K38/27 , A61K39/395 , A61P9/10 , A61P9/12 , C07K7/08 , C07K14/47 , C12N5/0783
CPC分类号: A61K39/0012 , A61K38/04 , A61K38/10 , A61K38/1841 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K39/0005 , A61K39/3955 , A61K2039/5158 , A61K2039/55505 , C07K7/08 , C07K14/495 , C07K14/5406 , C07K14/5428 , C07K14/5443 , C07K14/5446 , C07K14/55 , C07K14/775 , C07K16/246 , C12N5/0636
摘要: 個体における高血圧及び/又はそれに関連する症状を治療及び/又は予防するための免疫調節剤、T細胞、組成物、方法及びシステム。
【選択図】図2B-
公开(公告)号:JP2003507011A
公开(公告)日:2003-02-25
申请号:JP2001515701
申请日:2000-08-04
IPC分类号: C12N15/09 , A61K31/56 , A61K38/00 , A61K39/395 , A61P1/04 , A61P5/14 , A61P11/06 , A61P25/00 , A61P29/00 , A61P31/22 , C07K5/10 , C07K5/11 , C07K7/06 , C07K7/08 , C07K14/54 , C07K16/44
CPC分类号: A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要: The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acids in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
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公开(公告)号:JP4804529B2
公开(公告)日:2011-11-02
申请号:JP2008330880
申请日:2008-12-25
IPC分类号: C07K14/52 , G01N33/53 , A61K38/00 , A61K38/20 , A61K39/395 , A61P31/12 , C07K14/54 , C07K14/73 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号: A61K38/2013 , A61K2039/505 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K16/244 , Y10S514/885 , A61K2300/00
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公开(公告)号:JP4278710B2
公开(公告)日:2009-06-17
申请号:JP50073495
申请日:1994-05-16
IPC分类号: A61K39/395 , G01N33/53 , A61K38/00 , A61K38/20 , A61P31/02 , A61P31/12 , C07K14/54 , C07K14/73 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号: A61K38/2013 , A61K2039/505 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K16/244 , Y10S514/885 , A61K2300/00
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