摘要:
PROBLEM TO BE SOLVED: To provide a method of preparing a microparticle for reducing the concentration of a residual solvent used in residual formulation.SOLUTION: A microparticle is placed in contact with a non-aqueous wash system to reduce the concentration of residual volume of a halogenated solvent used to biodegradably dissolve a biocompatible polymer which is used to form a microparticle containing a microparticle peptide. As a desired non-aqueous wash system, 100% ethanol or a blend of ethanol and heptane is included. Use a solvent blend of hardening solvent and wash solvent enables one process to harden and wash the microparticle, thereby eliminating the necessity of the wash process after the hardening process.
摘要:
PROBLEM TO BE SOLVED: To provide a production method for a liquid enclosing capsule, which effectively produces a liquid enclosing capsule excellent in retentivity and releasing of a core material, to provide a liquid enclosing capsule obtained by the production method for a liquid enclosing capsule, and to provide a capsule-containing composition containing the liquid enclosing capsule.SOLUTION: A production method for a liquid enclosing capsule includes: a step of dispersing a mixed solution in an aqueous medium to prepare an emulsion liquid, wherein the mixed solution has a compound having a polymeric functional group and an alkoxy group in the molecule, and a high polar liquid; a step of polymerizing and condensing the compound having the polymeric functional group and the alkoxy group to prepare a primary capsule containing the high polar liquid as a core material in a shell containing a polymer; and a step of coating the surface of the primary capsule with a thermoplastic resin.