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1.发明公开신규 ２-아미노-이미다졸-４-온 화합물, 및 인지 장애,알쯔하이머병, 신경변성 및 치매의 치료에 사용될 약제의제조에 있어서의 이들의 용도 无效新型2-氨基咪唑-4-酮化合物及其用于治疗认知功能障碍，阿尔茨海默病，神经细胞增生和恶化的药物的制造中的应用
公开(公告)号：KR1020080080565A
公开(公告)日：2008-09-04
申请号：KR1020087014934
申请日：2006-11-20
Applicant: 아스트라제네카 아베 , 아스텍스 테라퓨틱스 리미티드
Inventor： 베르크,스테판 , 버로우스,제레미 , 체사리,지아니 , 콘그리브,마일스,스튜어트 , 헤드스트룀,요한 , 헬베르크,스벤 , 회그딘,카타리나 , 킬스트룀,야콥 , 콜모딘,카린 , 린드스트룀,요한 , 뮤레이,크리스토퍼 , 파텔,사힐
IPC: C07D233/88 , C07D413/10 , C07D417/04 , A61K31/4168
CPC classification number: C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1856
Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
Abstract translation: 本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。 这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。
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2.发明公开치매 및 신경변성 장애의 치료용 글리코겐 신타제 키나제억제제로서의 신규 ２-페닐-이미다조[４,５-ｂ]피리딘유도체 无效新颖的2-苯基 - 咪唑并[4,5-B]吡啶衍生物作为治疗神经细胞和神经损伤病症的GLYCOGEN SYNTHASE激酶的抑制剂
公开(公告)号：KR1020080057334A
公开(公告)日：2008-06-24
申请号：KR1020087010754
申请日：2006-10-02
Applicant: 아스트라제네카 아베
IPC: C07D471/04 , A61K31/437 , A61P19/08 , A61P25/00
CPC classification number: C07D471/04
Abstract: The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
Abstract translation: 本发明涉及作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂化物的新的式（I）化合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和 所述活性化合物在治疗中的用途。
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Patent Agency Ranking3.发明公开글리코겐 신타제 키나제 (ＧＳＫ3) 관련 질환의 치료를 위한 이미다졸-피리미딘 유도체 无效用于治疗与GLYCOGEN SYNTHASE KINASE（GSK3）相关的疾病的咪唑并吡啶衍生物
公开(公告)号：KR1020090024817A
公开(公告)日：2009-03-09
申请号：KR1020097001642
申请日：2007-06-26
Applicant: 아스트라제네카 아베
IPC: C07D403/14 , C07D405/14 , A61K31/506 , A61P25/28
CPC classification number: C07D401/14 , C07D405/14
Abstract: The present invention relates to a compound of formula (I) as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of compound of formula (I) and to new intermediates used therein.
Abstract translation: 本发明涉及作为游离碱的式（I）化合物或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物及其中使用的新中间体的方法。
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4.发明公开치매 및 신경변성 장애의 치료에 사용하기 위한 글리코겐신타제 키나제 3 억제제로서의 신규이미다조[4,5-Ｂ]피리딘 유도체 无效新颖的咪唑并[4,5-B]吡啶衍生物作为治疗神经病学和神经损伤性疾病的GLYCOGEN SYNTHASE KINASE 3的抑制剂
公开(公告)号：KR1020080059285A
公开(公告)日：2008-06-26
申请号：KR1020087010753
申请日：2006-10-02
Applicant: 아스트라제네카 아베
IPC: C07D471/04 , A61K31/437 , A61K31/444 , A61P19/08
CPC classification number: C07D471/04
Abstract: The present invention relates to new compounds of formula (I) Wherein X is or Y; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
Abstract translation: 本发明涉及新的式（I）化合物，其中X是或Y; 作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂化物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。
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5.发明公开글리코겐 신타제 키나제 (ＧＳＫ3) 관련 질환의 치료를 위한 이미다졸-피리미딘 유도체 无效用于治疗与GLYCOGEN SYNTHASE KINASE（GSK3）相关的疾病的咪唑并吡啶衍生物
公开(公告)号：KR1020090024295A
公开(公告)日：2009-03-06
申请号：KR1020097001643
申请日：2007-06-26
Applicant: 아스트라제네카 아베
IPC: C07D403/14 , C07D405/14 , A61K31/506 , A61P25/28
CPC classification number: C07D403/14 , C07D403/04 , C07D405/14
Abstract: The present invention relates to a compound of formula (I): [Chemical formula should be inserted here. Please see paper copy] (I) as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of the compound of formula (I).
Abstract translation: 本发明涉及式（I）化合物：[化学式应在此插入。 请参阅纸本]（I）作为游离碱或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物的方法。
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6.发明公开신규 피리미딘 유도체 및 요법에서의 이들의 용도 및알쯔하이머병의 예방 및/또는 치료용 의약의 제조에있어서의 피리미딘 유도체의 용도 无效新的吡嗪衍生物及其在治疗中的使用，以及在制备用于预防和/或治疗阿尔茨海默病的药物中使用吡嗪衍生物
公开(公告)号：KR1020080059423A
公开(公告)日：2008-06-27
申请号：KR1020087010755
申请日：2006-10-02
Applicant: 아스트라제네카 아베
Inventor： 안데르손,라르스 , 아르젤,에르완 , 베르크,스테판 , 버로우스,제레미 , 헬베르크,스펜 , 휘르타,페르난도 , 페데르센,토르벤 , 라인,토비아스 , 로티씨,디디에르 , 스타프,카린 , 투레크,도미니카
IPC: C07D403/04 , C07D405/14 , A61K31/506 , A61P25/16
CPC classification number: C07D405/14 , A61K31/506 , C07D401/14 , C07D403/04 , C07D409/14
Abstract: The present invention relates to use of compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, as pharmaceutical ingredients for treatment of dementia, Alzheimer's Disease, Parkinson's Disease, Frontotemporal dementia Parkinson's Type, Parkinson dementia complex of Guam, HIV dementia, diseases with associated neurofibrillar tangle pathologies and/or dementia pugilistica.
Abstract translation: 本发明涉及式（I）化合物作为其盐的游离碱或其药学上可接受的盐，溶剂合物或溶剂合物，其制备方法和其中使用的新中间体作为治疗痴呆的药物成分，阿尔茨海默病 疾病，帕金森氏病，额颞叶痴呆，帕金森氏病，关岛的帕金森氏综合征，艾滋病毒性痴呆，伴有神经原纤维缠结病和/或痴呆症的疾病。
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公开(公告)号：KR1020020080479A
公开(公告)日：2002-10-23
申请号：KR1020027011797
申请日：2001-03-06
Applicant: 아스트라제네카 아베
IPC: C07D401/04
Abstract: 본 발명은 화학식 (I)의 화합물(여기서 변수는 본 출원에 정의되어 있음), 그의 제조 방법, 그를 포함하는 조성물 및 CCR5 수용체 활성을 조절하는 그의 용도에 관한 것이다.
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