公开(公告)号：US06697669B2

公开(公告)日：2004-02-24

申请号：US09352809

申请日：1999-07-13

申请人： Nagendu B. Dev ,  Gunter A. Hofmann ,  Edward Nolan ,  Dietmar P. Rabussay ,  Arnt Tonnessen ,  Georg Widera ,  Lei Zhang

发明人： Nagendu B. Dev ,  Gunter A. Hofmann ,  Edward Nolan ,  Dietmar P. Rabussay ,  Arnt Tonnessen ,  Georg Widera ,  Lei Zhang

IPC分类号： A61N130

CPC分类号： A61N1/327 ,  A61N1/0424 ,  A61N1/0452 ,  A61N1/306 ,  A61N1/325

摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

公开(公告)号：US06654636B1

公开(公告)日：2003-11-25

申请号：US09625825

申请日：2000-07-26

申请人： Nagendu B. Dev ,  Gunter A. Hofmann ,  Edward Nolan ,  Dietmar P. Rabussay ,  Arnt Tonnessen ,  Georg Widera ,  Lei Zhang

发明人： Nagendu B. Dev ,  Gunter A. Hofmann ,  Edward Nolan ,  Dietmar P. Rabussay ,  Arnt Tonnessen ,  Georg Widera ,  Lei Zhang

IPC分类号： A61N130

CPC分类号： A61N1/327 ,  A61N1/0424 ,  A61N1/0452 ,  A61N1/306 ,  A61N1/325

摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

摘要翻译： 本发明描述了体内方法，使用脉冲电场将治疗剂递送到皮肤和肌肉的细胞中用于局部和全身治疗。 特别地，治疗剂包括裸体或配制的核酸，多肽和化学治疗剂。

公开(公告)号：US06192270B1

公开(公告)日：2001-02-20

申请号：US09134245

申请日：1998-08-14

申请人： Gunter A. Hofmann ,  Dietmar Rabussay ,  Arnt Tonnessen

发明人： Gunter A. Hofmann ,  Dietmar Rabussay ,  Arnt Tonnessen

IPC分类号： A61N130

CPC分类号： A61N1/0424 ,  A61N1/042 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/30 ,  A61N1/325

摘要： An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at least a portion of the distal surface and extending through at least a portion of the plurality of through holes and onto at least a portion of the proximal surface, a second electrode disposed on at least a portion of the proximal surface and in closely spaced relation with the first electrode for engaging a tissue surface through which to apply an electric field, and an insulating barrier that is disposed on at least a portion of the proximal surface of the carrier between the first electrode and the second electrode.

摘要翻译： 一种用于反式表面分子传递的装置和方法的电极组件，包括具有近端表面，远端表面和从近端表面到远端表面的多个通孔的非导电载体，第一电极 设置在所述远端表面的至少一部分上并且延伸穿过所述多个通孔的至少一部分并且延伸到所述近端表面的至少一部分上，第二电极，设置在所述近端表面的至少一部分上并且紧密地 与用于接合施加电场的组织表面的第一电极间隔开的关系;以及设置在第一电极和第二电极之间的载体近端表面的至少一部分上的绝缘屏障。