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    Electrical field therapy with reduced histopathological change in muscle
    3.
    发明授权
    Electrical field therapy with reduced histopathological change in muscle 有权
    电场治疗减少肌肉组织病理学变化

    公开(公告)号：US07570992B2

    公开(公告)日：2009-08-04

    申请号：US10756946

    申请日：2004-01-13

    申请人： Edward Nolan ,  Dietmar P. Rabussay ,  Georg Widera ,  Lei Zhang

    发明人： Edward Nolan ,  Dietmar P. Rabussay ,  Georg Widera ,  Lei Zhang

    IPC分类号： A61N1/30 ,  A61M31/00

    CPC分类号： A61N1/325 ,  A61N1/306

    摘要： In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

    摘要翻译： 提供体内方法，用于使电场向受试者递送治疗性治疗，同时减少诱导靶肌肉组织中的组织病理学变化，例如与由脉冲电场引起的免疫应答的诱导或扩增相关。 治疗剂可以递送到肌肉细胞，用于局部和全身治疗，具有最佳的基因表达和最小的组织损伤。 特别地，治疗剂包括裸体或配制的核酸，多肽和化学治疗剂。

    Electrical field therapy with reduced histopathological change in muscle
    4.
    发明授权
    Electrical field therapy with reduced histopathological change in muscle 有权
    电场治疗减少肌肉组织病理学变化

    公开(公告)号：US06678556B1

    公开(公告)日：2004-01-13

    申请号：US10165657

    申请日：2002-06-07

    申请人： Edward Nolan ,  Dietmar P. Rabussay ,  Georg Widera ,  Lei Zhang

    发明人： Edward Nolan ,  Dietmar P. Rabussay ,  Georg Widera ,  Lei Zhang

    IPC分类号： A61N130

    CPC分类号： A61N1/325 ,  A61N1/306

    摘要： In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

    摘要翻译： 提供体内方法，用于使电场向受试者递送治疗性治疗，同时减少诱导靶肌肉组织中的组织病理学变化，例如与由脉冲电场引起的免疫应答的诱导或扩增相关。 治疗剂可以递送到肌肉细胞，用于局部和全身治疗，具有最佳的基因表达和最小的组织损伤。 特别地，治疗剂包括裸体或配制的核酸，多肽和化学治疗剂。

    Mileage and fuel purchase monitoring device for vehicles
    5.
    发明授权
    Mileage and fuel purchase monitoring device for vehicles 失效
    车辆里程和燃油购买监控装置

    公开(公告)号：US06424893B1

    公开(公告)日：2002-07-23

    申请号：US09667465

    申请日：2000-09-22

    申请人： Patrick Byrne ,  Edward Barnes ,  Edward Nolan

    发明人： Patrick Byrne ,  Edward Barnes ,  Edward Nolan

    IPC分类号： G06F1900

    CPC分类号： G01C22/02 ,  G07C5/0883

    摘要： A mileage and fuel purchase monitoring device for vehicles including a data collecting system that is connected with an odometer of a truck or other motor vehicle. The data collecting system is preferably secured to a dashboard of the truck for easy access by the driver. The data collecting system is provided with a keyboard and a display for entering relevant information related to a planned trip to be made.

    摘要翻译： 一种用于车辆的里程和燃料购买监控装置，包括与卡车或其他机动车辆的里程计连接的数据收集系统。 数据采集​​系统优选地被固定到卡车的仪表板上，以便驾驶员方便地接近。 数据采集​​系统具有键盘和用于输入与要进行的计划旅行相关的相关信息的显示器。

    CLADDING PANEL
    6.
    发明申请
    CLADDING PANEL 审中-公开
    封面

    公开(公告)号：US20080115452A1

    公开(公告)日：2008-05-22

    申请号：US11934380

    申请日：2007-11-02

    申请人： Edward Nolan

    发明人： Edward Nolan

    IPC分类号： E04B1/04 ,  E04G21/00

    CPC分类号： B28B19/0053 ,  B28B23/02 ,  E04C2/041

    摘要： A prefabricated reinforced brick panel has a plurality of bricks arranged in a spaced-apart array with mortar between the bricks. The array comprises a number of superimposed rows of bricks. The bricks in each row are staggered relative to the bricks in each adjacent row of bricks. Each brick has a number of vertical through holes extending between a top and a bottom of the brick. These through holes are aligned in the array and vertical reinforcing bars are inserted into aligned holes and extend between a top and a bottom of the panel. Two offset vertical reinforcing bars pass through each brick. Transverse reinforcing bars are mounted in the mortar between rows of bricks.

    摘要翻译： 预制的加强砖面板具有多个砖，间隔开地排列成砖块之间的砂浆。 阵列包括多个重叠的砖块。 每排砖块相对于相邻排砖块中的砖块交错。 每个砖都有一些垂直通孔，在砖的顶部和底部之间延伸。 这些通孔在阵列中对准，并且垂直的钢筋插入对准的孔中并且在面板的顶部和底部之间延伸。 两个偏移的垂直钢筋通过每个砖。 横向钢筋安装在砖之间的砂浆中。

    Electroporation devices
    7.
    发明申请
    Electroporation devices 审中-公开
    电穿孔装置

    公开(公告)号：US20060224192A1

    公开(公告)日：2006-10-05

    申请号：US11443115

    申请日：2006-05-30

    申请人： Steve Dimmer ,  Gunter Hofmann ,  Daniel Holt ,  Gurvinder Nanda ,  Edward Nolan

    发明人： Steve Dimmer ,  Gunter Hofmann ,  Daniel Holt ,  Gurvinder Nanda ,  Edward Nolan

    IPC分类号： A61N1/30 ,  A61N1/18

    CPC分类号： A61N1/327 ,  A61N1/08 ,  A61N1/306 ,  A61N1/325

    摘要： Improved devices and methods for performing electroporation-mediated delivery agents to cells is described. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.

    摘要翻译： 描述了用于对细胞进行电穿孔介导的递送试剂的改进的装置和方法。 该方法包括定位第一电极和第二电极，使得在第一电极和第二电极之间通过的电信号通过电池。 该方法还包括在第一电极和第二电极之间传递电信号，电信号具有大于约10kHz的频率。 在该方法的一个实施例中，电信号具有双极波形。 在该方法的另一个实施方案中，电极位于治疗部位，例如肿瘤，用于药物的体内递送。

    Modular wall element
    8.
    发明授权
    Modular wall element 失效
    模块化墙体元件

    公开(公告)号：US06412244B2

    公开(公告)日：2002-07-02

    申请号：US09396551

    申请日：1999-09-03

    申请人： Edward Nolan

    发明人： Edward Nolan

    IPC分类号： B44F700

    CPC分类号： E04H17/16 ,  E01F8/0023 ,  E02D27/01 ,  E04B1/04 ,  E04C2/06 ,  E04C2002/008

    摘要： A prefabricated modular wall element (20) comprises a precast reinforced concrete wall panel (21) having a front face (24). A plurality of spaced-apart individual slabs (33) of stone or brick are partially embedded in the front face (24) of the panel (21) during casting of the panel (21) and project outwardly of the front face (24) with channels being formed between the slabs (33). The slabs are arranged on the front face (24) such that the front face (24) simulates a wall constructed of stone. A pair of spaced-apart support legs (38) are provided at a bottom (27) of the wall panel (21) for keying into a concrete foundation (42) to support the wall element (1) in an upright.

    摘要翻译： 预制模块化墙体元件（20）包括具有前表面（24）的预制钢筋混凝土墙板（21）。 多个间隔开的石头或砖的单独板坯（33）在铸造面板（21）期间部分地嵌入面板（21）的前表面（24）中并且以正面（24）向外突出， 通道形成在板坯（33）之间。 平板布置在前表面（24）上，使得前表面（24）模拟由石头构成的墙壁。 一对间隔开的支撑腿（38）设置在壁板（21）的底部（27）处，用于键入到混凝土基座（42）中，以支撑竖直的壁元件（1）。

    Detachable ramp carrying system for moving containers
    9.
    发明授权
    Detachable ramp carrying system for moving containers 失效
    用于移动容器的可拆卸斜坡承载系统

    公开(公告)号：US06349840B1

    公开(公告)日：2002-02-26

    申请号：US09671541

    申请日：2000-09-27

    申请人： Patrick Byrne ,  Edward Nolan

    发明人： Patrick Byrne ,  Edward Nolan

    IPC分类号： B65D9000

    CPC分类号： B65D88/542 ,  B60P1/43

    摘要： A detachable ramp carrying system for moving containers including a pair of securement brackets coupled with the horizontal lower segments of opposed L-shaped brackets of the moving container. The securement brackets support the ramp thereon disposed below the closed lower end of the container.

    摘要翻译： 一种用于移动容器的可拆卸斜坡承载系统，包括与移动容器的相对的L形支架的水平​​下段连接的一对固定支架。 固定支架支撑其上设置在容器的封闭下端下方的斜面。