公开(公告)号：US20220031776A1

公开(公告)日：2022-02-03

申请号：US16644641

申请日：2018-09-07

Applicant: Keio University ,  BiomX Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

Inventor： Kenya Honda ,  Koji Atarashi ,  Seiko Narushima ,  Eran Elinav ,  Rotem Sorek ,  Efrat Khabra ,  Hava Ben David ,  Eyal Weinstock ,  Sarah Pollock ,  Yulia Matiuhin ,  Naomi Zak

IPC: A61K35/76 ,  C12N7/00

Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.

公开(公告)号：US20240100105A1

公开(公告)日：2024-03-28

申请号：US18481324

申请日：2023-10-05

Applicant: BIOMX LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eyal Weinstock ,  Hava Ben-David ,  Kobi Konstantin Sudakov ,  Ayelet Moses ,  Sarah Rachel Pollock ,  Rotem Sorek ,  Naomi Bluma Zak

IPC: A61K35/76 ,  A61K9/00 ,  A61K45/06 ,  A61P17/10 ,  A61P31/04

CPC classification number: A61K35/76 ,  A61K9/0014 ,  A61K45/06 ,  A61P17/10 ,  A61P31/04 ,  C12N2795/00032

Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes (P. acnes) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.

公开(公告)号：US20210177920A1

公开(公告)日：2021-06-17

申请号：US16770432

申请日：2018-12-04

Applicant: BIOMX LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eyal Weinstock ,  Hava Ben-David ,  Kobi Konstantin Sudakov ,  Ayelet Moses ,  Sarah Rachel Pollock ,  Rotem Sorek ,  Naomi Bluma Zak

IPC: A61K35/76 ,  A61K9/00 ,  A61P17/10 ,  A61P31/04 ,  A61K45/06

Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes (P. acnes) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.

公开(公告)号：US20240173369A1

公开(公告)日：2024-05-30

申请号：US18283909

申请日：2022-03-30

Applicant: BIOMX LTD.

Inventor： Lior Moshe Zelcbuch ,  Rotem Edgar ,  Irit Sherman ,  Dana Inbar ,  Noa Ben-Yishai ,  Maya Kahan-Hanum

IPC: A61K35/76 ,  A61K31/427 ,  A61K31/7036 ,  A61K38/16 ,  A61K45/06 ,  A61P31/04 ,  C12N7/00

CPC classification number: A61K35/76 ,  A61K31/427 ,  A61K31/7036 ,  A61K38/164 ,  A61K45/06 ,  A61P31/04 ,  C12N7/00 ,  C12N2795/00032

Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Pseudomonas aeruginosa, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-10. Uses thereof are also disclosed.

公开(公告)号：US20230390349A1

公开(公告)日：2023-12-07

申请号：US18033822

申请日：2021-11-11

Applicant: Biomx Ltd.

Inventor： Lior Moshe ZELCBUCH ,  Sagit YAHAV ,  Maya KAHAN-HANUM ,  Naomi Bluma ZAK ,  Lihi NINIO-MANY

IPC: A61K35/76 ,  A61P35/00

CPC classification number: A61K35/76 ,  A61P35/00

Abstract: A method of treating a disease associated with Fusobacterium nucleatum infection in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one isolated bacteriophage capable of infecting a Fusobacterium nucleatum bacterial species, wherein said at least one bacteriophage has a genomic nucleic acid sequence at least 85% identical to the nucleic acid sequence as set forth in SEQ ID NOs: 1-7 or 15-20. Compositions for treating the disease are also disclosed.

公开(公告)号：US20240415904A1

公开(公告)日：2024-12-19

申请号：US18289842

申请日：2022-05-12

Applicant: BIOMX LTD.

Inventor： Lior Moshe Zelcbuch ,  Nufar Buchshtab ,  Yifat Elharar ,  Julian Nicenboim ,  Tamar Lin

IPC: A61K35/76 ,  A61P31/04 ,  C12N7/00

Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Staphylococcus aureus, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-7. Uses thereof are also disclosed.

公开(公告)号：US20240075084A1

公开(公告)日：2024-03-07

申请号：US18273295

申请日：2022-01-20

Applicant: Biomx Ltd.

Inventor： Eyal WEINSTOCK ,  Iddo Nadav WEINER ,  Maya KAHAN-HANUM ,  Efrat KHABRA ,  Noa BEN-YISHAI ,  Dana INBAR ,  Rotem EDGAR

IPC: A61K35/76 ,  A61P31/04 ,  C12N7/00

CPC classification number: A61K35/76 ,  A61P31/04 ,  C12N7/00 ,  C12N2795/10021 ,  C12N2795/10032

Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Klebsiella pneumoniae, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-30. Uses thereof are also disclosed.

公开(公告)号：US20220152132A1

公开(公告)日：2022-05-19

申请号：US17436693

申请日：2020-03-06

Applicant: Keio University ,  Biomx Ltd.

Inventor： Kenya HONDA ,  Koji ATARASHI ,  Seiko NARUSHIMA ,  Efrat KHABRA ,  Hava BEN DAVID ,  Eyal WEINSTOCK ,  Yulia MATIUHIN ,  Naomi Bluma ZAK

IPC: A61K35/76 ,  A61P31/04

Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.