公开(公告)号：US20230390349A1

公开(公告)日：2023-12-07

申请号：US18033822

申请日：2021-11-11

Applicant: Biomx Ltd.

Inventor： Lior Moshe ZELCBUCH ,  Sagit YAHAV ,  Maya KAHAN-HANUM ,  Naomi Bluma ZAK ,  Lihi NINIO-MANY

IPC: A61K35/76 ,  A61P35/00

CPC classification number: A61K35/76 ,  A61P35/00

Abstract: A method of treating a disease associated with Fusobacterium nucleatum infection in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one isolated bacteriophage capable of infecting a Fusobacterium nucleatum bacterial species, wherein said at least one bacteriophage has a genomic nucleic acid sequence at least 85% identical to the nucleic acid sequence as set forth in SEQ ID NOs: 1-7 or 15-20. Compositions for treating the disease are also disclosed.

公开(公告)号：US20240075084A1

公开(公告)日：2024-03-07

申请号：US18273295

申请日：2022-01-20

Applicant: Biomx Ltd.

Inventor： Eyal WEINSTOCK ,  Iddo Nadav WEINER ,  Maya KAHAN-HANUM ,  Efrat KHABRA ,  Noa BEN-YISHAI ,  Dana INBAR ,  Rotem EDGAR

IPC: A61K35/76 ,  A61P31/04 ,  C12N7/00

CPC classification number: A61K35/76 ,  A61P31/04 ,  C12N7/00 ,  C12N2795/10021 ,  C12N2795/10032

Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Klebsiella pneumoniae, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-30. Uses thereof are also disclosed.