公开(公告)号：US07595323B2

公开(公告)日：2009-09-29

申请号：US10806834

申请日：2004-03-22

Applicant: Dong-Yeon Kim ,  Jae-Gun Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Woo-Chul Bae ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Jae-Gun Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Woo-Chul Bae ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: C07D239/28 ,  A61K31/505

CPC classification number: C07D401/04 ,  C07D401/12

Abstract: The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, or cervical cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及对肺癌，胃癌，结肠癌，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病等有显着影响的N-苯基-2-嘧啶胺衍生物 ，膀胱癌，直肠癌或子宫颈癌等，其温血动物及其盐。 本发明还涉及一种制备该化合物的方法以及用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。

公开(公告)号：US07501424B2

公开(公告)日：2009-03-10

申请号：US11813175

申请日：2005-09-07

Applicant: Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: C07D239/28 ,  A61K31/505

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及由上述式（1）表示的新型N-苯基-2-嘧啶胺衍生物及其对温血动物（例如肺癌，胃癌，结肠癌）中对癌症的显着影响的盐 ，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病，膀胱癌，直肠癌，子宫颈癌，淋巴瘤等。本发明还涉及一种制备该化合物的方法， 用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。

公开(公告)号：US20080096899A1

公开(公告)日：2008-04-24

申请号：US11813175

申请日：2005-09-07

Applicant: Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

Inventor： Dong-Yeon Kim ,  Dae-Jin Cho ,  Gong-Yeal Lee ,  Hong-Youb Kim ,  Seok-Hun Woo ,  Yong-Seok Kim ,  Sun-Ahe Lee ,  Byoung-Cheol Han

IPC: A61K31/506 ,  A61P35/00 ,  A61K31/497 ,  C07D403/04 ,  C07D417/04

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Abstract translation: 本发明涉及由上述式（1）表示的新型N-苯基-2-嘧啶胺衍生物及其对温血动物（例如肺癌，胃癌，结肠癌）中对癌症的显着影响的盐 ，胰腺癌，肝癌，前列腺癌，乳腺癌，慢性或急性白血病，血液恶性肿瘤，脑病，膀胱癌，直肠癌，子宫颈癌，淋巴瘤等。本发明还涉及一种制备该化合物的方法， 用于治疗上述各种疾病的药物组合物，其包含有效量的作为活性成分的化合物以及药学上可接受的惰性载体。