公开(公告)号：US10335048B2

公开(公告)日：2019-07-02

申请号：US14543071

申请日：2014-11-17

Applicant: William Rooney ,  Charles Springer, Jr. ,  Xin Li

Inventor： William Rooney ,  Charles Springer, Jr. ,  Xin Li

IPC: A61B5/055 ,  A61B5/0265 ,  G01R33/563 ,  A61B5/0295 ,  A61B5/026 ,  A61B5/00 ,  G01R33/48 ,  G01R33/50 ,  G01R33/56

Abstract: Provided herein are methods and apparatuses for determining a level of cellular metabolic activity for a region of interest in order to detect and map on-going gliovascular unit metabolic activity using high-resolution 1H2O MRI. In one example approach, a computer-implemented method includes receiving a first set of DCE-MRI time-course data for a region, wherein a contrast agent is administered prior to imaging, identifying a region of interest from the first set of DCE-MRI time-course data for further analysis, performing shutter-speed pharmacokinetic analysis of the time-course data associated with the region of interest using computer-implemented software to obtain a finite and non-zero mean water molecule capillary lifetime in the region of interest, and indicating a level of cellular metabolic activity in the brain based on the mean water molecule capillary lifetime.

公开(公告)号：US20150141804A1

公开(公告)日：2015-05-21

申请号：US14543071

申请日：2014-11-17

Applicant: William Rooney ,  Charles Springer, JR. ,  Xin Li

Inventor： William Rooney ,  Charles Springer, JR. ,  Xin Li

IPC: A61B5/026 ,  A61B5/00 ,  G01R33/48 ,  A61B5/0295 ,  G01R33/563 ,  G01R33/56

CPC classification number: A61B5/0263 ,  A61B5/0013 ,  A61B5/0037 ,  A61B5/0295 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/4866 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/748 ,  G01R33/4828 ,  G01R33/5601 ,  G01R33/5608 ,  G01R33/56366

Abstract: Provided herein are methods and apparatuses for determining a level of cellular metabolic activity for a region of interest in order to detect and map on-going gliovascular unit metabolic activity using high-resolution 1H2O MRI. In one example approach, a computer-implemented method includes receiving a first set of DCE-MRI time-course data for a region, wherein a contrast agent is administered prior to imaging, identifying a region of interest from the first set of DCE-MRI time-course data for further analysis, performing shutter-speed pharmacokinetic analysis of the time-course data associated with the region of interest using computer-implemented software to obtain a finite and non-zero mean water molecule capillary lifetime in the region of interest, and indicating a level of cellular metabolic activity in the brain based on the mean water molecule capillary lifetime.

Abstract translation: 本文提供了用于确定感兴趣区域的细胞代谢活动水平的方法和装置，以便使用高分辨率1H2O MRI来检测和映射正在进行的心血管单位代谢活动。 在一个示例性方法中，计算机实现的方法包括接收用于区域的第一组DCE-MRI时间段数据，其中在成像之前施用造影剂，从第一组DCE-MRI识别感兴趣区域 用于进一步分析的时间过程数据，使用计算机实现的软件执行与感兴趣区域相关联的时间线数据的快门速度药代动力学分析，以获得感兴趣区域中的有限和非零平均水分子毛细血管寿命， 并基于平均水分子毛细管寿命指示脑中的细胞代谢活性水平。