公开(公告)号：US20080076736A1

公开(公告)日：2008-03-27

申请号：US11834505

申请日：2007-08-06

Applicant: John Goddard ,  Donald Picker ,  Samuil Umansky ,  Steven Price ,  Jac Wijkmans ,  Edward Boyd ,  Anthony Baxter

Inventor： John Goddard ,  Donald Picker ,  Samuil Umansky ,  Steven Price ,  Jac Wijkmans ,  Edward Boyd ,  Anthony Baxter

IPC: A61K31/66 ,  A61P43/00 ,  C07F9/02 ,  C12N5/06

CPC classification number: C07F9/091

Abstract: The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.

Abstract translation: 本发明提供含有溶血磷脂酸的抗凋亡组合物和制备和使用组合物的方法。 此类组合物还可含有LPA增效剂，包括蛋白质，脂质膜结构和聚合物如聚乙二醇。 组合物可另外含有其它药学上有效的试剂，例如药物，抗生素，伤口愈合剂和抗氧化剂。

公开(公告)号：US20070015780A1

公开(公告)日：2007-01-18

申请号：US10548794

申请日：2004-03-10

Applicant: Donald Picker ,  Geoffrey Henson ,  Simon Fricker ,  Kunwar Shailubhai ,  Gary Jacob

Inventor： Donald Picker ,  Geoffrey Henson ,  Simon Fricker ,  Kunwar Shailubhai ,  Gary Jacob

IPC: A61K31/4747 ,  A61K31/403

CPC classification number: A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K45/06 ,  A61K2300/00

Abstract: A method of treating cancer by administering a therapeutically effective amount of a compound represented by the following Formula (I), or salt, hydrate, or solvate thereof; wherein: n represents a number from 3 to 7; m represents a number from 1 to 2; R1 and R2 independently represent a hydrogen atom or are a substituted or unsubstituted, branched or unbranched or cyclic, alkyl provided that the total number of carbon atoms represented by R1 and R2 when taken together is no less than 5 and no greater than 10; or R1 and R2 together independently represent a cyclic alkyl group having no less than 3 or no more than 7 carbon atoms; R3 and R4 independently represent a hydrogen atom or a saturated or unsaturated, substituted or unsubstituted, branched or unbranched or cyclic, hydrocarbyl radical.

Abstract translation: 通过施用治疗有效量的由下式（I）表示的化合物或其盐，水合物或溶剂合物来治疗癌症的方法; 其中：n表示3〜7的数; m表示1〜2的数; R 1和R 2独立地表示氢原子，或者是取代或未取代的，支链或非支链或环状烷基，条件是由R 1表示的碳原子总数， 当共在一起时，SUB> 1和R 2 2不小于5且不大于10; 或R 1和R 2共同独立地表示具有不少于3个或不超过7个碳原子的环状烷基; R 3和R 4独立地表示氢原子或饱和或不饱和的取代或未取代的支链或非支链或环状烃基。

公开(公告)号：US20060063738A1

公开(公告)日：2006-03-23

申请号：US11236403

申请日：2005-09-26

Applicant: Ian Bathurst ,  Matthew Foehr ,  J. Goddard ,  Samuil Umansky ,  John Bradley ,  Donald Picker

Inventor： Ian Bathurst ,  Matthew Foehr ,  J. Goddard ,  Samuil Umansky ,  John Bradley ,  Donald Picker

IPC: A61K31/685

CPC classification number: A61K31/685

Abstract: The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.

公开(公告)号：US20050250801A1

公开(公告)日：2005-11-10

申请号：US10796292

申请日：2004-03-10

Applicant: Kunwar Shailubhai ,  Gary Jacob ,  Donald Picker ,  Geoffrey Henson ,  Simon Fricker

Inventor： Kunwar Shailubhai ,  Gary Jacob ,  Donald Picker ,  Geoffrey Henson ,  Simon Fricker

IPC: A61K20060101 ,  A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K38/00 ,  A61K45/06

CPC classification number: A61K31/403 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4747 ,  A61K45/06 ,  A61K2300/00

Abstract: A method of treating cancer by administering a therapeutically effective amount of a compound represented by the following Formula (I), or salt, hydrate, or solvate thereof: wherein: n represents a number from 3 to 7; m represents a number from 1 to 2; R1 and R2 independently represent a hydrogen atom or are a substituted or unsubstituted, branched or unbranched or cyclic, alkyl provided that the total number of carbon atoms represented by R1 and R2 when taken together is no less than 5 and no greater than 10; or R1 and R2 together independently represent a cyclic alkyl group having no less than 3 or no more than 7 carbon atoms; R3 and R4 independently represent a hydrogen atom or a saturated or unsaturated, substituted or unsubstituted, branched or unbranched or cyclic, hydrocarbyl radical.

Abstract translation: 通过给予治疗有效量的由下式（I）表示的化合物或其盐，水合物或溶剂合物来治疗癌症的方法：其中：n表示3至7的数; m表示1〜2的数; R 1和R 2独立地表示氢原子，或者是取代或未取代的，支链或非支链或环状烷基，条件是由R 1表示的碳原子总数， 当共在一起时，SUB> 1和R 2 2不小于5且不大于10; 或R 1和R 2共同独立地表示具有不少于3个或不超过7个碳原子的环状烷基; R 3和R 4独立地表示氢原子或饱和或不饱和的取代或未取代的支链或非支链或环状烃基。