公开(公告)号：US20090325920A1

公开(公告)日：2009-12-31

申请号：US11909278

申请日：2006-03-24

申请人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

发明人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

IPC分类号： A61K31/57 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K31/57

摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

公开(公告)号：US20050187188A1

公开(公告)日：2005-08-25

申请号：US11085889

申请日：2005-03-22

申请人： Donald Stein ,  Stuart Hoffman

发明人： Donald Stein ,  Stuart Hoffman

IPC分类号： A61K47/40 ,  A61K31/57 ,  A61P7/10 ,  A61P17/02 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61K31/724

CPC分类号： A61K31/57

摘要： The present invention provides methods for conferring a neuroprotective effect on a population of cells in a subject following a traumatic injury to the central nervous system. Specifically, the methods of the invention provide for the administration of a progestin or progestin metabolite following a traumatic brain injury. The progestin or progestin metabolite is administered at therapeutically effective concentrations that produce a neuroprotective effect (i.e., a decrease in the loss of neuronal activity) and reduces and/or prevents the various physiological events leading to neurodegeneration, such as, cerebral edema and the immune/inflammatory response.

摘要翻译： 本发明提供了对中枢神经系统创伤性损伤后对受试者的细胞群赋予神经保护作用的方法。 具体地，本发明的方法提供了在创伤性脑损伤后给药孕激素或孕激素代谢物。 孕激素或孕激素代谢物以治疗有效浓度施用，其产生神经保护作用（即，神经元活性丧失的减少），并且减少和/或预防导致神经变性的各种生理事件，例如脑水肿和免疫 /炎症反应。

公开(公告)号：US06258526B1

公开(公告)日：2001-07-10

申请号：US09487429

申请日：2000-01-19

申请人： Wilfred Donald Stein ,  Miriam Viviana Kott

发明人： Wilfred Donald Stein ,  Miriam Viviana Kott

IPC分类号： C12Q100

CPC分类号： G01N33/5076 ,  G01N2800/52 ,  Y10S436/809

摘要： The invention provides an ex-vivo test kit for testing the effectiveness of reversers of multidrug resistance in the blood, serum or plasma of a patient containing the reversers, the kit comprising, a plurality of cell membranes from highly drug-resistant cells, the cell membranes containing proteins which pump drugs and the membranes being respectively attached to a plurality of support surfaces, and a dye which provides a light signal, which dye is pumped by the proteins contained in the membranes.

摘要翻译： 本发明提供了一种用于测试含有逆转剂的患者的血液，血清或血浆中的多药耐药逆转者的有效性的试剂盒，该试剂盒包括来自高度耐药细胞的多个细胞膜，细胞 含有蛋白质的膜，其将药物和膜分别连接到多个支撑表面，以及提供光信号的染料，所述染料被膜中包含的蛋白质泵送。

公开(公告)号：US20120245133A1

公开(公告)日：2012-09-27

申请号：US13454503

申请日：2012-04-24

申请人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

发明人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

IPC分类号： A61K31/57 ,  A61P25/00

CPC分类号： A61K31/57

摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。

公开(公告)号：US20070078117A1

公开(公告)日：2007-04-05

申请号：US11527816

申请日：2006-09-27

申请人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

发明人： Stuart Hoffman ,  Arthur Kellermann ,  Donald Stein ,  David Wright ,  Douglas Lowery-North

IPC分类号： A61K31/57

CPC分类号： A61K31/57

摘要： Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

摘要翻译： 提供了用创伤性中枢神经系统损伤治疗受试者的方法，更具体地说，是创伤性脑损伤。 所述方法包括包含孕酮恒定或两级给药方案的治疗。 在一种方法中，需要治疗的受试者至少进行一次治疗循环，其中治疗循环包括施用孕酮的治疗有效的两级静脉内给药方案。 两级给药方案包括第一时间段，其中向受试者施用较高剂量的孕酮，随后是第二时间段，其中向受试者施用较小时剂量的孕酮。