公开(公告)号：US09989527B2

公开(公告)日：2018-06-05

申请号：US15005776

申请日：2016-01-25

Applicant: Alverix, Inc.

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC: G01N33/543 ,  G01N21/84 ,  G01N33/558 ,  G01N21/17 ,  G01N21/64 ,  G01N21/27

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

公开(公告)号：US20170192022A1

公开(公告)日：2017-07-06

申请号：US15403553

申请日：2017-01-11

Applicant: Theranos, Inc.

Inventor： Shaunak Roy ,  Melissa Takahashi ,  Ian Gibbons ,  Edmond Ku ,  Thanh Dang ,  Tammy Burd ,  Adam Vollmer ,  Elizabeth A. Holmes

IPC: G01N33/86 ,  G01N27/07

CPC classification number: G01N33/86 ,  G01N27/06 ,  G01N27/07 ,  G01N33/49 ,  G01N33/5302 ,  G01N2800/52 ,  Y10S435/973 ,  Y10S436/809 ,  Y10T436/106664

Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US09575058B2

公开(公告)日：2017-02-21

申请号：US14534064

申请日：2014-11-05

Applicant: Theranos, Inc.

Inventor： Shaunak Roy ,  Malissa Takahashi ,  Ian Gibbons ,  Edmond Ku ,  Thanh Dang ,  Tammy Burd ,  Adam Vollmer ,  Elizabeth A. Holmes

IPC: C12M1/34 ,  G01N33/53 ,  G01N33/49 ,  G01N27/06

CPC classification number: G01N33/86 ,  G01N27/06 ,  G01N27/07 ,  G01N33/49 ,  G01N33/5302 ,  G01N2800/52 ,  Y10S435/973 ,  Y10S436/809 ,  Y10T436/106664

Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Abstract translation: 本发明提供允许从生物流体检测分析物的流体装置和系统。 所述方法和装置对于为各种医疗应用提供点护理测试特别有用。

公开(公告)号：US09494527B2

公开(公告)日：2016-11-15

申请号：US13713864

申请日：2012-12-13

Applicant: Step Ahead Innovations, Inc.

Inventor： James E. Clark

IPC: G01N21/15 ,  G01N21/88 ,  G01N21/77 ,  C02F1/00 ,  G01N33/18 ,  G01N21/85 ,  F21V8/00 ,  G01N21/78 ,  G01N31/22 ,  A01K63/04 ,  G01N21/64

CPC classification number: G01N21/77 ,  A01K63/04 ,  C02F1/008 ,  C02F2103/42 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2209/06 ,  C02F2209/14 ,  C02F2209/15 ,  C02F2209/18 ,  G01N21/15 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8507 ,  G01N21/88 ,  G01N31/22 ,  G01N33/18 ,  G01N2021/758 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/127 ,  G02B6/0001 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/12 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383 ,  Y10T436/193333 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Cleaning systems for optics of optical readers to periodically clean one or more surfaces of the optics of matter that may deposit on surface(s) and that might interfere with the performance of the reader. In an example, the cleaning system is used on a chemical indicator apparatus that includes one or more chemical indicators that are read by an optical reader having an optic. During use, the chemical indicator apparatus is moved relative optic during a reading mode. A cleaning element is engaged with the chemical indicator apparatus so as to have a neutral position in which it cannot contact the optic during the reading mode. When it is desired to clean the optic, the chemical indicator apparatus is moved in a manner that causes the cleaning element to move from the neutral position to a deployed position in which it contacts the optic in a manner that cleans the optic as the apparatus continues to be moved.

Abstract translation: 用于光学读取器的光学系统的清洁系统周期性地清洁可能沉积在表面上并且可能干扰读取器的性能的物质光学元件的一个或多个表面。 在一个示例中，清洁系统用于化学指示器装置，其包括由具有光学元件的光学读取器读取的一个或多个化学指示器。 在使用期间，在读取模式期间，化学指示器装置相对于光学元件移动。 清洁元件与化学指示器装置接合，以便具有在读取模式期间其不能接触光学元件的中性位置。 当需要清洁光学元件时，化学指示器装置以使得清洁元件从中立位置移动到展开位置的方式移动，在该展开位置中，该化学指示器装置以与装置相连的方式清洁光学元件的方式移动 被移动

公开(公告)号：US09463431B2

公开(公告)日：2016-10-11

申请号：US14928607

申请日：2015-10-30

Applicant: President and Fellows of Harvard College

Inventor： J. Christopher Love ,  Hidde L. Ploegh ,  Jehnna Ronan

IPC: G01N33/53 ,  B01J19/00 ,  G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  B82Y30/00 ,  G01N33/50 ,  G01N33/68 ,  G01N33/577 ,  G01N33/531

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/12 ,  B82Y30/00 ,  G01N21/6452 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6854 ,  Y10S436/809

Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.

Abstract translation: 提供了筛选测定和进行这种测定的方法。 在某些实施例中，可以设计测定和方法以确定两种或更多种类是否可以彼此结合。 在一些实例中，测定和方法可用于确定已知抗原是否与未知单克隆抗体结合。

公开(公告)号：US09400259B2

公开(公告)日：2016-07-26

申请号：US14181028

申请日：2014-02-14

Applicant: Bioarray Solutions, Ltd

Inventor： Michael Seul

IPC: G01N33/543 ,  G01N27/447 ,  B01J19/00 ,  C12Q1/68 ,  C40B40/04 ,  G01N33/68 ,  G02B3/00 ,  H05H3/04 ,  B01L3/00 ,  C40B40/00 ,  G01N15/14

CPC classification number: B01J19/0046 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0663 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0454 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/00 ,  C40B40/04 ,  G01N15/1468 ,  G01N27/447 ,  G01N33/54313 ,  G01N33/54386 ,  G01N33/6845 ,  G01N2015/149 ,  G01N2015/1497 ,  G02B3/0012 ,  G02B3/0056 ,  G02B3/0075 ,  H05H3/04 ,  Y10S435/808 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S436/806 ,  Y10S436/808 ,  Y10S436/809 ,  Y10T436/25125 ,  C12Q2565/501 ,  C12Q2563/155 ,  C12Q2565/607

Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.

Abstract translation: 一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。 表面附近颗粒的光控电动组装依靠三个功能元件的组合：交流电场引起的平面聚集体组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。 本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。 本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。 此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

公开(公告)号：US09243997B2

公开(公告)日：2016-01-26

申请号：US14019166

申请日：2013-09-05

Applicant: Alverix, Inc.

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC: G01N33/00 ,  G01N21/17 ,  G01N21/84 ,  G01N33/558

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

公开(公告)号：US09091631B2

公开(公告)日：2015-07-28

申请号：US13360081

申请日：2012-01-27

Applicant: Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC: G01N21/17 ,  G01N21/84 ,  G01N33/558

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

Abstract translation: 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

公开(公告)号：US20150010911A1

公开(公告)日：2015-01-08

申请号：US14456592

申请日：2014-08-11

Applicant: APPLIED BIOSYSTEMS, LLC ,  Health And Human Services, United States Of America,as Represented by the Secr

Inventor： James F. BROWN ,  Jonathan E. SILVER

IPC: C12Q1/68 ,  B01L3/00

CPC classification number: C12Q1/6806 ,  B01J2219/00317 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01L3/5027 ,  B01L3/5085 ,  B01L3/50851 ,  B01L3/5088 ,  B01L2200/06 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2400/0409 ,  C07H21/00 ,  C12Q1/6844 ,  C12Q1/686 ,  C40B60/14 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/2575

Abstract: A device for amplifying a target nucleic acid in a sample containing one or more target nucleic acids may include a planar fluidic assembly comprising a flow channel and an inlet, wherein the inlet is in flow communication with the flow channel and is configured to introduce sample containing one or more target nucleic acids into the flow channel, wherein the flow channel has a substantially uniform cross-section from a first end to a second end. A plurality of nucleic acid primers can be disposed at discrete regions along and within the flow channel, each of the plurality of nucleic acid primers being complementary to a portion of the one or more target nucleic acids in the sample to enable a primer-based amplification reaction of the one or more target nucleic acids. The discrete regions may be configured to retain sample and amplified product of the amplification reaction during the primer-based amplification reaction.

Abstract translation: 用于在含有一种或多种靶核酸的样品中扩增靶核酸的装置可以包括包括流动通道和入口的平面流体组件，其中所述入口与所述流动通道流动连通并且构造成引入含有 一个或多个目标核酸进入流动通道，其中流动通道具有从第一端到第二端的基本均匀的横截面。 多个核酸引物可以沿着流动通道内部和内部的离散区域设置，多个核酸引物中的每一个与样品中一个或多个靶核酸的一部分互补，以实现基于引物的扩增 一种或多种靶核酸的反应。 离散区域可以被配置为在基于引物的扩增反应期间保留扩增反应的样品和扩增产物。

公开(公告)号：US08900515B2

公开(公告)日：2014-12-02

申请号：US13304541

申请日：2011-11-25

Applicant: Meng Yi Lin

Inventor： Meng Yi Lin

IPC: G01N27/00 ,  G01N33/487 ,  G01N27/416 ,  G01N27/26 ,  G01N27/414

CPC classification number: G01N33/48771 ,  B01L2300/0825 ,  G01N27/26 ,  G01N27/4148 ,  G01N27/4163 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25375

Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.

Abstract translation: 本发明提供了一种生物传感装置，其包括输入单元，分析单元，处理单元和用于存储作为用于校准生物传感装置的基础的结果数据值的设置单元，以建立条带的校准参数 生物传感装置