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公开(公告)号：US08569307B2
公开(公告)日：2013-10-29
申请号：US13493045
申请日：2012-06-11
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/497 , C07D413/14
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US08222414B2
公开(公告)日：2012-07-17
申请号：US12671180
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： C07D413/14 , A61K31/497
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US08436038B2
公开(公告)日：2013-05-07
申请号：US12671038
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A01N43/38 , A61K31/405
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
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公开(公告)号：US20120252798A1
公开(公告)日：2012-10-04
申请号：US13493045
申请日：2012-06-11
申请人： Soon Ha KIM , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha KIM , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/427 , A61K31/4439 , A61K31/422 , A61K31/4245 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/4985 , A61P1/16 , A61P25/28 , A61P9/10 , A61P3/10 , A61P1/18 , A61P31/04 , A61P31/12 , A61P37/00 , A61P19/02 , A61P13/12 , A61P35/02 , A61P35/00 , A61P25/00 , A61P17/06 , A61P29/00 , A61P13/00 , A61P17/02 , A61P17/16 , A61P25/16 , A61P31/00 , A61P3/04 , A61P7/02 , A61P9/12 , A61P3/00 , A61P37/06 , A61K31/454
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US20100210647A1
公开(公告)日：2010-08-19
申请号：US12671180
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/427 , C07D417/04 , C07D413/04 , C07D417/14 , A61K31/5377 , A61K31/496 , A61K31/422 , A61P25/00 , A61P17/00 , A61P25/16 , A61P9/10
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US20100197673A1
公开(公告)日：2010-08-05
申请号：US12671038
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/541 , C07D401/02 , A61K31/4439 , C07D209/04 , A61K31/404 , A61K31/497 , C07D417/14 , C07D403/02 , A61K31/496 , C07D413/02 , A61K31/5377 , A61K31/454 , C07D231/56 , A61K31/416 , A61P1/16 , A61P25/00 , A61P3/10 , A61P31/00 , A61P19/02 , A61P35/00 , A61P35/02 , A61P11/00 , A61P17/00
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的吲哚或吲唑化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚或吲唑化合物作为活性成分。
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