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公开(公告)号：US20100210647A1
公开(公告)日：2010-08-19
申请号：US12671180
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/427 , C07D417/04 , C07D413/04 , C07D417/14 , A61K31/5377 , A61K31/496 , A61K31/422 , A61P25/00 , A61P17/00 , A61P25/16 , A61P9/10
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US08569307B2
公开(公告)日：2013-10-29
申请号：US13493045
申请日：2012-06-11
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/497 , C07D413/14
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US08222414B2
公开(公告)日：2012-07-17
申请号：US12671180
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Seung Yup Paek , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： C07D413/14 , A61K31/497
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的新的吲哚化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚化合物作为活性成分。
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公开(公告)号：US20100197673A1
公开(公告)日：2010-08-05
申请号：US12671038
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A61K31/541 , C07D401/02 , A61K31/4439 , C07D209/04 , A61K31/404 , A61K31/497 , C07D417/14 , C07D403/02 , A61K31/496 , C07D413/02 , A61K31/5377 , A61K31/454 , C07D231/56 , A61K31/416 , A61P1/16 , A61P25/00 , A61P3/10 , A61P31/00 , A61P19/02 , A61P35/00 , A61P35/02 , A61P11/00 , A61P17/00
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
摘要翻译： 本发明涉及可用于预防或治疗细胞坏死和坏死相关疾病的吲哚或吲唑化合物，其药学上可接受的盐或异构体。 本发明还涉及用于预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包含所述吲哚或吲唑化合物作为活性成分。
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公开(公告)号：US08436038B2
公开(公告)日：2013-05-07
申请号：US12671038
申请日：2008-08-18
申请人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Sun Young Koo , Chul Woong Chung , Sung Bae Lee , Heui Sul Park , Seung Hyun Yoon , Hyo Shin Kwak , Dong Ook Seo , Eok Park
IPC分类号： A01N43/38 , A61K31/405
CPC分类号： C07D417/06 , A61K31/404 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.
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6.发明申请GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开含有活性成分的GLUCOKINASE激活剂和药物组合物公开(公告)号：US20100267708A1
公开(公告)日：2010-10-21
申请号：US12742991
申请日：2008-12-22
申请人： Soon Ha Kim , Sung Bae Lee , Seung Hyun Yoon , Mi Kyoung Cho , Kyoung Hee Kim , Heui Sul Park , Hyoung Jin Kim
发明人： Soon Ha Kim , Sung Bae Lee , Seung Hyun Yoon , Mi Kyoung Cho , Kyoung Hee Kim , Heui Sul Park , Hyoung Jin Kim
IPC分类号： A61K31/541 , C07D417/04 , C07D417/14 , C07D487/04 , A61K31/5377 , A61K31/519 , A61K31/496 , A61K31/44 , A61K31/427 , A61P3/10 , A61P3/04 , C07D403/04
CPC分类号： C07D417/14 , C07D417/04 , C07D487/04
摘要： The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.
摘要翻译： 本发明涉及对葡糖激酶具有优异活性的新的式（1）化合物，以及包含其作为活性成分的药物组合物。
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7.发明授权Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient 有权葡糖激酶活化剂和含有其作为活性成分的药物组合物公开(公告)号：US08309586B2
公开(公告)日：2012-11-13
申请号：US13329831
申请日：2011-12-19
申请人： Soon Ha Kim , Sung Bae Lee , Seung Hyun Yoon , Mi Kyoung Cho , Kyoung Hee Kim , Heui Sul Park , Hyoung Jin Kim
发明人： Soon Ha Kim , Sung Bae Lee , Seung Hyun Yoon , Mi Kyoung Cho , Kyoung Hee Kim , Heui Sul Park , Hyoung Jin Kim
IPC分类号： A61K31/427 , C07D417/04
CPC分类号： C07D417/14 , C07D417/04 , C07D487/04
摘要： Disclosed are new compounds of formula (1) exhibiting excellent activity for glucokinase, pharmaceutical compositions having the same as an active ingredient, and a method of using the same as an active ingredient for lowering blood glucose level: in which the substituents are as defined herein.
摘要翻译： 公开了对葡糖激酶具有优异活性的新的式（1）化合物，与活性成分相同的药物组合物及其用作降低血糖水平的活性成分的方法：其中取代基如本文所定义 。
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8.发明授权Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect 有权具有细胞，组织和器官保存作用的吲哚和吲唑衍生物公开(公告)号：US08349885B2
公开(公告)日：2013-01-08
申请号：US13534682
申请日：2012-06-27
申请人： Soon Ha Kim , Hyoung Jin Kim , Chul Woong Chung , Heui Sul Park , Hyo Shin Kwak , Sung Ho Kim , Jin Gu Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Chul Woong Chung , Heui Sul Park , Hyo Shin Kwak , Sung Ho Kim , Jin Gu Park
IPC分类号： A61K31/416 , A61K31/404 , C07D231/56 , C07D209/10
CPC分类号： C07D417/04 , C07D209/08 , C07D231/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.
摘要翻译： 本发明涉及一种用于保存细胞，组织和器官的组合物，其包含作为活性成分的式（1）的吲哚和吲唑化合物或其药学上可接受的盐或异构体，其可有效预防器官损伤，分离的细胞 由冷藏，移植手术或移植后再灌注引起的系统或组织; 保存方法; 和组合物的制备方法。
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公开(公告)号：US20120214804A1
公开(公告)日：2012-08-23
申请号：US13503857
申请日：2010-10-25
申请人： Soon Ha Kim , Hyoung Jin Kim , Heui Sul Park , Seon Yeong Gu , Hyo Shin Kwak , Du Hee Park , Hyo Soo Kim , Hyun Jai Cho , Ji Hyun Kim , Ju Young Kim , Kwang Min Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Heui Sul Park , Seon Yeong Gu , Hyo Shin Kwak , Du Hee Park , Hyo Soo Kim , Hyun Jai Cho , Ji Hyun Kim , Ju Young Kim , Kwang Min Park
IPC分类号： A61K31/4184 , A61P29/00 , A61P31/00 , A61P19/02 , A61P1/16 , A61P7/04 , A61P31/12 , A61P31/04 , A61P9/00 , A61P25/28 , A61P9/06 , A61P25/14 , A61P25/16 , A61P31/16 , A61P31/20 , A61P31/18 , A61K8/49 , C07D235/18 , C07D405/10 , A61K31/427 , C07D417/04 , A61K31/422 , C07D413/04 , A61K31/496 , C07D417/14 , A61K31/4985 , C07D487/04 , A61K31/541 , A61P9/10
CPC分类号： A61K31/541 , A61K8/492 , A61K31/404 , A61K31/4184 , A61K31/427 , A61K31/496 , A61K31/497 , A61K2800/522 , A61Q19/00 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.
摘要翻译： 本发明涉及药物组合物，其包含如说明书中定义的式（1），（2）或（3）化合物，其用于预防或治疗与氧化应激，线粒体功能障碍，缺氧损伤，坏死和/ 或缺血再灌注损伤，以及包含具有抗氧化作用的吲哚化合物的化妆品组合物。
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10.发明申请INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT 审中-公开具有细胞，组织和器官保护作用的吲哚和吲哚衍生物公开(公告)号：US20100291533A1
公开(公告)日：2010-11-18
申请号：US12811525
申请日：2009-01-05
申请人： Soon Ha Kim , Hyoung Jin Kim , Chul Woong Chung , Heui Sul Park , Hyo Shin Kwak , Sung Ho Kim , Jin Gu Park
发明人： Soon Ha Kim , Hyoung Jin Kim , Chul Woong Chung , Heui Sul Park , Hyo Shin Kwak , Sung Ho Kim , Jin Gu Park
CPC分类号： C07D417/04 , C07D209/08 , C07D231/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.
摘要翻译： 本发明涉及一种用于保存细胞，组织和器官的组合物，其包含作为活性成分的式（1）的吲哚和吲唑化合物或其药学上可接受的盐或异构体，其可有效预防器官损伤，分离的细胞 由冷藏，移植手术或移植后再灌注引起的系统或组织; 保存方法; 和组合物的制备方法。
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