公开(公告)号：US07459294B2

公开(公告)日：2008-12-02

申请号：US10913180

申请日：2004-08-06

申请人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

发明人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

IPC分类号： C12P19/44 ,  C12P19/60 ,  C12P19/62 ,  C12P17/00 ,  C12P17/02

CPC分类号： C12P17/08

摘要： During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in contact with the culture medium. The adsorbent resin reversibly adsorbs precursor compound and, as un-adsorbed precursor compound is converted to product compound, adsorbed precursor compound is released from the resin, thus maintaining the concentration of precursor compound within the pre-selected range.

摘要翻译： 在通过发酵生产产品化合物期间，通过使吸附树脂与培养基接触，将前体化合物的浓度保持在预先选择的浓度范围内。 吸附剂树脂可逆地吸附前体化合物，当未吸附的前体化合物转化为产物化合物时，吸附的前体化合物从树脂中释放出来，从而将前体化合物的浓度保持在预选范围内。