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    Method of producing a compound by fermentation
    1.
    发明授权
    Method of producing a compound by fermentation 失效
    通过发酵生产化合物的方法

    公开(公告)号：US07459294B2

    公开(公告)日：2008-12-02

    申请号：US10913180

    申请日：2004-08-06

    申请人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

    发明人： Timothy A. Leaf ,  Ruchir P. Desai ,  Peter Licari ,  Elaine Jennifer Woo

    IPC分类号： C12P19/44 ,  C12P19/60 ,  C12P19/62 ,  C12P17/00 ,  C12P17/02

    CPC分类号： C12P17/08

    摘要： During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in contact with the culture medium. The adsorbent resin reversibly adsorbs precursor compound and, as un-adsorbed precursor compound is converted to product compound, adsorbed precursor compound is released from the resin, thus maintaining the concentration of precursor compound within the pre-selected range.

    摘要翻译： 在通过发酵生产产品化合物期间，通过使吸附树脂与培养基接触，将前体化合物的浓度保持在预先选择的浓度范围内。 吸附剂树脂可逆地吸附前体化合物，当未吸附的前体化合物转化为产物化合物时，吸附的前体化合物从树脂中释放出来，从而将前体化合物的浓度保持在预选范围内。

    Method for production of polyketides
    3.
    发明授权
    Method for production of polyketides 有权
    聚酮化合物的生产方法

    公开(公告)号：US07067290B2

    公开(公告)日：2006-06-27

    申请号：US10712897

    申请日：2003-11-12

    申请人： Rika Regentin ,  Ruchir P. Desai

    发明人： Rika Regentin ,  Ruchir P. Desai

    IPC分类号： C12P17/06 ,  C12P7/42 ,  C12P7/26 ,  C12P7/62

    CPC分类号： C12P19/62 ,  C12P17/06

    摘要： A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to a value conducive to polyketide product stability, continuing the fermentation until a maximal titer of polyketide is achieved, and optionally extracting the polyketide from the culture.

    摘要翻译： 通过发酵生产聚酮化合物的方法包括以下步骤：在有助于细胞生长的pH值下生长足够产生培养物的时间的产生聚酮生物的生物体的培养物，将培养物的pH降低到值 有利于聚酮化合物产品的稳定性，继续发酵，直到达到最大滴度的聚酮化合物，并且任选地从培养物中提取聚酮化合物。