公开(公告)号：US20240352498A1

公开(公告)日：2024-10-24

申请号：US18751380

申请日：2024-06-24

申请人： The Regents of the University of California ,  Plant Bioscience Limited

发明人： Yuzhong Liu ,  Samantha Aiko Crowe ,  Jay D. Keasling ,  Xiaoyue Chen ,  Graham Arthur Hudson ,  Fei Gan ,  Henrik V. Scheller ,  James Reed ,  Laetitia Martin

IPC分类号： C12P19/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12P5/00

CPC分类号： C12P19/60 ,  C12N9/0069 ,  C12N9/0083 ,  C12N9/1077 ,  C12N9/1205 ,  C12N9/1241 ,  C12N9/88 ,  C12P5/007 ,  C12Y113/99001 ,  C12Y114/99 ,  C12Y207/01043 ,  C12Y207/07064 ,  C12Y402/01076

摘要： The present invention relates inter alia to methods of biosynthetic production of QS-21, precursors and variants thereof, and to related aspects.

公开(公告)号：US12098405B2

公开(公告)日：2024-09-24

申请号：US17522523

申请日：2021-11-09

申请人： The Regents of the University of California

发明人： John Eugene Dueber ,  Zachary Nicholas Russ ,  Tammy Melody Hsu ,  Terry Don Johnson, Jr. ,  Bernardo Cervantes ,  Ramya Lakshmi Prathuri ,  Shyam Pravin Bhakta ,  Arthur Muir Fong, III ,  Luke Nathaniel Latimer

IPC分类号： C12N9/00 ,  C09B7/02 ,  C09B7/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/14 ,  C12P17/16 ,  C12P19/60

CPC分类号： C12P19/60 ,  C09B7/02 ,  C09B7/04 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/13 ,  C12N9/14 ,  C12P17/165 ,  C12Y114/13008 ,  C12Y114/14001 ,  C12Y204/01115 ,  C12Y208/02001

摘要： The present disclosure relates to the biosynthesis of indigoid dye precursors and their conversion to indigoid dyes. Specifically, the present disclosure relates to methods of using polypeptides to produce indigoid dye precursors from indole feed compounds, and the use of the indigoid dye precursors to produce indigoid dyes.

公开(公告)号：US11987829B2

公开(公告)日：2024-05-21

申请号：US17429459

申请日：2020-02-11

申请人： LES LABORATOIRES SERVIER

发明人： Cyrille Pauthenier ,  André Le Jeune ,  Hélène Scornec ,  Célia Roussel ,  Laetitia Joubert

IPC分类号： C12P19/60 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90

CPC分类号： C12P19/60 ,  C12N9/0042 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1007 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12Y106/02004 ,  C12Y114/11022 ,  C12Y114/13011 ,  C12Y114/14 ,  C12Y204/01 ,  C12Y204/01185 ,  C12Y205/01006 ,  C12Y402/01076 ,  C12Y403/01023 ,  C12Y403/01024 ,  C12Y505/01006 ,  C12Y602/01012

摘要： The present invention relates to a recombinant microorganism which is modified to be capable of producing diosmin and hesperidin and to the use thereof for producing diosmin and/or hesperidin.

公开(公告)号：US11773423B2

公开(公告)日：2023-10-03

申请号：US15753378

申请日：2016-08-17

申请人： ZuChem, Inc.

发明人： Micah Douglas Shepherd

IPC分类号： C12P19/60 ,  C12P19/18 ,  C12N9/12 ,  C12N9/88 ,  A61K35/66 ,  C12N9/90 ,  C12N9/10 ,  C12N9/04 ,  A61K35/00

CPC分类号： C12P19/60 ,  A61K35/66 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1241 ,  C12N9/88 ,  C12N9/90 ,  C12P19/18 ,  C12Y101/01049 ,  C12Y206/01 ,  C12Y207/07024 ,  C12Y402/01046 ,  C12Y501/03013 ,  A61K35/00 ,  Y02A50/30

摘要： The invention provides compositions and methods for the production of TDP-deoxysugars.

公开(公告)号：US20230124589A1

公开(公告)日：2023-04-20

申请号：US17906396

申请日：2021-03-15

申请人： DoubleRainbow Biosciences Inc.

发明人： Sheng Ding ,  Yasmin-Pei Kamal Chau ,  Jacob Donald Stanley Wirth ,  Tian Xu ,  Jing-Ke Weng

IPC分类号： C12P19/60 ,  C12N9/10 ,  A61K47/61 ,  A61K47/54

摘要： Ivacaftor glycosides and methods of making ivacaftor glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to ivacaftor to yield ivacaftor glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

公开(公告)号：US20220340941A1

公开(公告)日：2022-10-27

申请号：US17711259

申请日：2022-04-01

申请人： MARS, INCORPORATED ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Thomas M. COLLINS ,  Rebecca J. ROBBINS ,  Randall POWERS ,  Justin SIEGEL ,  Pamela Ruth DENISH ,  Kathryn Gwendolyn GUGGENHEIM

IPC分类号： C12P17/16 ,  C12P19/60 ,  C12N9/18 ,  A23L5/43

摘要： Methods for converting mixtures of anthocyanins occurring in fruit or vegetable juice or extract into particular anthocyanin molecules having desirable colorant properties are provided herein. The method of the present disclosure can be employed to increase the amount of particular anthocyanin molecules, while lowering the total number of anthocyanin molecules present in the natural juice and/or extract. The disclosure is also directed to anthocyanin molecules prepared by the methods of present disclosure and to enzymes capable of catalyzing reactions that provide such effects.

公开(公告)号：US11286511B2

公开(公告)日：2022-03-29

申请号：US16617503

申请日：2017-11-30

申请人： SOUTH CHINA UNIVERSITY OF TECHNOLOGY

发明人： Xiaofeng Li ,  Xuan Xin ,  Guanglei Zhao

IPC分类号： C12P19/60 ,  C12N1/20

摘要： A method for preparing troxerutin ester using whole-cell catalysis belongs to the fields of biological catalysis and pharmaceutical chemistry. The method specifically includes the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole-cell catalyst, and performing a reaction under oscillation at a reaction temperature of 25° C. to 55° C.; and after the reaction is finished, separating and purifying a product by column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The invention has the advantages of mild reaction conditions, environmental friendliness, simple process, fewer side reactions and high selectivity.

公开(公告)号：US10660258B2

公开(公告)日：2020-05-26

申请号：US14914463

申请日：2015-11-26

申请人： VEGITABLE PHARMACEUTICAL CO., LTD

发明人： Hiroyuki Ide ,  Tsuyoshi Ide ,  Koji Ochiai

IPC分类号： A01C1/00 ,  A01G22/00 ,  C12P7/26 ,  C12P7/22 ,  C12P17/06 ,  C12P19/60 ,  A01G7/00 ,  A01G17/02 ,  A01N63/00 ,  G01N30/06 ,  G01N33/00 ,  G01N30/02

摘要： The present invention provides a novel method of manufacturing germinated plant seeds suitable for producing a large amount of phytoalexin, a method of manufacturing raw material seeds for germination induction for use in manufacture of the above germinated plant seeds, an extract composition of the germinated plant seeds and a screening method for a plant seed candidate for use in producing a target substance. The method of manufacturing raw material seeds for germination induction comprises a pre-treatment step of maintaining plant seeds under atmosphere conditions of a carbon dioxide concentration of 400 ppm or more and/or an oxygen concentration of 19 vol % or less continuously for 5 hours or more.

公开(公告)号：US10526283B2

公开(公告)日：2020-01-07

申请号：US15144288

申请日：2016-05-02

申请人： PARION SCIENCES, INC.

发明人： Michael Ross Johnson ,  William R. Thelin

IPC分类号： A61K31/265 ,  C07C327/36 ,  C07C327/28 ,  C07C327/22 ,  C07C323/16 ,  C12P19/60 ,  C12N9/02 ,  C12N9/10 ,  C12P17/16 ,  A61K9/00 ,  A61K9/16 ,  A61K31/047 ,  A61K31/133 ,  A61K31/341 ,  A61K31/385 ,  A61K31/683 ,  A61K33/14 ,  C07D307/68 ,  C07D339/00 ,  C07D339/08 ,  C07F9/6578 ,  C07C321/20 ,  C07D241/12 ,  C07C329/12 ,  C07D307/64

摘要： Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.

公开(公告)号：US20180265880A1

公开(公告)日：2018-09-20

申请号：US15932337

申请日：2018-02-16

申请人： Wisconsin Alumni Research Foundation

发明人： Hiroshi A. Maeda ,  Marcos Viana de Oliveira

IPC分类号： C12N15/82 ,  C12N9/02 ,  C12P19/60

CPC分类号： C12N15/825 ,  C12N9/001 ,  C12N15/8222 ,  C12N15/8243 ,  C12N15/8251 ,  C12P13/22 ,  C12P19/60 ,  C12Y103/01043

摘要： The invention generally relates to arogenate dehydrogenase polynucleotides and methods of using the same. More specifically, the invention relates in part to compositions including arogenate dehydrogenase polynucleotides from beet varieties and other Caryophyllales species and methods of using the same.