公开(公告)号：US08188144B2

公开(公告)日：2012-05-29

申请号：US12757717

申请日：2010-04-09

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

IPC: A61K31/35 ,  A61K31/38 ,  A61K31/40 ,  C07D315/00 ,  C07D207/38

CPC classification number: C07D311/62 ,  A01N1/02 ,  A01N1/0226 ,  C07D207/36 ,  C07D215/22 ,  C07D307/58 ,  C07D311/30 ,  C07D333/32 ,  C07D335/06 ,  C12N5/0606 ,  C12N2501/999

Abstract: The invention is directed to compounds of Formula (I) or salts thereof. The invention is also directed to use of the compounds of formula (I) in the in vitro preservation of living animal cells. The living cells can be isolated cells, such as stem cells, or groups of cells such as tissue or an organ.

Abstract translation: 本发明涉及式（I）的化合物或其盐。 本发明还涉及式（I）化合物在活体动物细胞的体外保存中的用途。 活细胞可以是分离的细胞，例如干细胞或细胞组，例如组织或器官。

公开(公告)号：US20120094384A1

公开(公告)日：2012-04-19

申请号：US13260248

申请日：2010-04-09

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

IPC: C12N5/071 ,  C12N5/077 ,  C12N5/079

CPC classification number: C12N5/0606 ,  C12N2501/999

Abstract: The present invention provides a method for differentiating an undifferentiated cell, said method comprising contacting an undifferentiated cell with certain compounds of Formula (I) or a salt thereof.

Abstract translation: 本发明提供了一种分化未分化细胞的方法，所述方法包括使未分化细胞与某些式（I）化合物或其盐接触。

公开(公告)号：US20130267586A1

公开(公告)日：2013-10-10

申请号：US13879130

申请日：2011-10-13

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

IPC: C07D311/62 ,  C07D309/40

CPC classification number: C07D311/62 ,  C07D309/40 ,  C07D311/26

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

Abstract translation: 本发明提供式I化合物或其盐，以及这些化合物用于治疗涉及氧化损伤的疾病或病症的用途，用于预防对哺乳动物的皮肤的紫外线损伤以及用于预防或逆转其效果 的老化，或用于治疗或预防干性皮肤。

公开(公告)号：US09359323B2

公开(公告)日：2016-06-07

申请号：US13879130

申请日：2011-10-13

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Richard Charles Hartley

IPC: C07D311/00 ,  C07D315/00 ,  C07D311/62 ,  C07D309/40 ,  C07D311/26

CPC classification number: C07D311/62 ,  C07D309/40 ,  C07D311/26

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

公开(公告)号：US20100267132A1

公开(公告)日：2010-10-21

申请号：US12757717

申请日：2010-04-09

Applicant: Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

Inventor： Donald Barton McPhail ,  Graeme James Cook ,  Andrew Scott Johnstone

IPC: C12N5/0735 ,  C12N5/02 ,  C07D311/22

CPC classification number: C07D311/62 ,  A01N1/02 ,  A01N1/0226 ,  C07D207/36 ,  C07D215/22 ,  C07D307/58 ,  C07D311/30 ,  C07D333/32 ,  C07D335/06 ,  C12N5/0606 ,  C12N2501/999

Abstract: The invention is directed to compounds of Formula (I) or salts thereof. The invention is also directed to use of the compounds of formula (I) in the in vitro preservation of living animal cells. The living cells can be isolated cells, such as stem cells, or groups of cells such as tissue or an organ.

Abstract translation: 本发明涉及式（I）的化合物或其盐。 本发明还涉及式（I）化合物在活体动物细胞的体外保存中的用途。 活细胞可以是分离的细胞，例如干细胞或细胞组，例如组织或器官。