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1.发明授权公开(公告)号：US07711416B1
公开(公告)日：2010-05-04
申请号：US11136213
申请日：2005-05-24
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for non-invasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflection coatings are not required. Transient neural surface displacement of less than 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射涂层。 可以检测到振幅小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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2.发明申请MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 有权使用相敏感光学相干反射测量法测量神经功能公开(公告)号：US20140171807A1
公开(公告)日：2014-06-19
申请号：US13720563
申请日：2012-12-19
CPC分类号： A61B5/4041 , A61B5/0066 , A61B5/0075 , A61B5/0082 , A61B5/40 , A61B5/4029 , A61B5/6821 , A61B5/7225 , A61B5/7282 , A61N1/00 , A61N1/3605 , A61N5/0622
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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3.发明授权公开(公告)号：US08352022B2
公开(公告)日：2013-01-08
申请号：US12717735
申请日：2010-03-04
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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4.发明申请MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 有权使用相敏感光学相干反射测量法测量神经功能公开(公告)号：US20100249609A1
公开(公告)日：2010-09-30
申请号：US12717735
申请日：2010-03-04
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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公开(公告)号：US4062354A
公开(公告)日：1977-12-13
申请号：US592361
申请日：1975-07-01
CPC分类号： A61B5/6864 , A61B5/0031 , A61B5/031 , G01L9/0036 , G01L9/007 , G01L9/105
摘要： Intracranial pressure transducer System, wherein a holding bracket containing and supporting sensor elements of the apparatus is surgically positioned, through an opening in the skull, against the dura of a neurosurgical patient. The elements within the holding bracket transmit signals in the form of radiated electromagnetic waves to a receiver located outside the body of the patient. The received signals may be recorded on magnetic tape, may be converted to audible sounds, and/or may be recorded on charts, or otherwise suitably preserved and/or presented for use in monitoring the intracranial pressure of the patient.
摘要翻译： 颅内压力传感器系统，其中容纳和支持的装置的传感器元件的支架通过外科手术定位，通过颅骨中的开口抵靠神经外科患者的硬脑膜。 保持托架内的元件以辐射电磁波的形式将信号发送到位于患者体外的接收器。 接收到的信号可以记录在磁带上，可以被转换为可听见的声音，和/或可以被记录在图表上，或以其他方式被适当地保存和/或呈现以用于监视患者的颅内压。
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