Method and device for label-free all-optical neural regulation and imaging

    公开(公告)号:US12121320B2

    公开(公告)日:2024-10-22

    申请号:US17771457

    申请日:2019-07-31

    发明人: Peng Li Lin Yao

    摘要: A method and a device for label-free all-optical neural regulation and imaging are provided. The method stimulates a neural activity through an infrared laser pulse, and acquires an optical scattered signal caused by the neural activity by optical coherence tomography (OCT) to realize label-free all-optical neural regulation and imaging. The method specifically includes: aiming an infrared laser at a target brain region, injecting a certain time series of laser pulses, synchronously scanning and imaging the target brain region by OCT, analyzing a relative change of an OCT scattered signal before and after laser stimulation, and acquiring a brain function signal based on OCT to realize synchronous neural regulation and imaging. The method and the device enable synchronous neural regulation and imaging without causing crosstalk between the regulation and imaging channels, and without the need for injection of a contrast agent or viral transfection.

    Time-of-flight optical measurement and decoding of fast-optical signals

    公开(公告)号:US12064208B2

    公开(公告)日:2024-08-20

    申请号:US17663992

    申请日:2022-05-18

    申请人: HI LLC

    IPC分类号: A61B5/00 A61B5/026

    摘要: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.

    OPTICAL COHERENCE TOMOGRAPHY IMAGE GENERATION DEVICE AND DENTAL CADCAM DEVICE

    公开(公告)号:US20240260833A1

    公开(公告)日:2024-08-08

    申请号:US18550376

    申请日:2022-06-20

    发明人: Takeshi TOMOE

    摘要: An optical coherence tomography image generation device comprising: a tooth three-dimensional information measurer that irradiates a tooth with measuring laser light to measure tooth three-dimensional information, and visualizes the tooth three-dimensional information to display a tooth image on a display device; a laser cutter that irradiates the tooth with cutting laser light to cut the tooth; a two-dimensional scanning mechanism that scans laser light, which is either the measuring laser light and/or the cutting laser light, in two dimensions; a probe that includes the two-dimensional scanning mechanism, and outputs the laser light, which has passed through the two-dimensional scanning mechanism, from a tip thereof; and an optical path coaxializer that coaxializes an optical path of the measuring laser light entering the two-dimensional scanning mechanism with an optical path of the cutting laser light entering the two-dimensional scanning mechanism.