公开(公告)号：US20210247403A1

公开(公告)日：2021-08-12

申请号：US17050366

申请日：2019-04-23

Applicant: HealthTell Inc.

Inventor： Aaron ARVEY ,  Gang AN ,  Ted TARASOW ,  Bill COLSTON

IPC: G01N33/68 ,  G16H50/20 ,  G16H50/30

Abstract: Provided herein are methods of measuring immune health in a subject. In some embodiments, methods herein comprise, obtaining an immunological measurement from a biological sample from the subject, wherein the immunological measurement comprises antibody-peptide binding. Also provided are computer-implemented methods of predicting immune health, including computer-implemented machine learning algorithms useful in such predictions.

公开(公告)号：US20160041158A1

公开(公告)日：2016-02-11

申请号：US14773751

申请日：2014-03-14

Applicant: ARIZONA BOARD OF REGENTS, ON BEHALF OF ARIZONA, STATE UNIVERSITY ,  HEALTHTELL INC.

Inventor： Neal WOODBURY ,  Stephen JOHNSTON ,  Zhan Gong ZHAO ,  Matthew GREVING

IPC: G01N33/543

CPC classification number: G01N33/54366

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract translation: 本申请提供了用于这种阵列的免疫标记和质量控制的阵列。 还公开了肽阵列及其用于诊断，治疗和研究的用途。

公开(公告)号：US20190234945A1

公开(公告)日：2019-08-01

申请号：US16312168

申请日：2017-06-20

Applicant: HealthTell Inc.

Inventor： Michael William ROWE ,  Theodore Michael TARASOW ,  Jonathan Scott MELNICK

IPC: G01N33/564

CPC classification number: G01N33/564 ,  C07K14/00 ,  G01N2800/24 ,  G01N2800/60

Abstract: Provided herein are methods, assays and devices for the detection and diagnosis of autoimmune diseases, including systemic lupus erythematosus. The methods, assays and devices provided herein analyzes binding patterns of peripheral-blood antibodies on peptide array that correlates well with current systemic lupus erythematosus clinical assessment standards.

公开(公告)号：US20200309774A1

公开(公告)日：2020-10-01

申请号：US16312131

申请日：2017-06-20

Applicant: HealthTell Inc.

Inventor： Robert William GERWIEN ,  Theodore Michael TARASOW ,  Jonathan Scott MELNICK

IPC: G01N33/564 ,  G01N33/68

Abstract: Provided herein are methods, assays and devices for the differential diagnosis and detection of disease progression of autoimmune diseases. The methods, assays and devices provided herein produce and analyze binding patterns of peripheral-blood antibodies on mimetic peptide arrays that differentiate autoimmune diseases, and identify patients progressing to internal organ complications such as interstitial lung disease (ILD), and gastric antral vascular ectasia (GAVE), or renal involvement.

公开(公告)号：US20200209236A1

公开(公告)日：2020-07-02

申请号：US16348704

申请日：2017-11-10

Applicant: HealthTell Inc.

Inventor： Robert William GERWIEN ,  Theodore Michael TARASOW ,  Jonathan Scott MELNICK ,  Kathryn Frances SYKES ,  Michael William ROWE

IPC: G01N33/564

Abstract: The disclosed embodiments concern methods, devices, and systems for identifying candidate biomarkers useful for the diagnosis, prognosis, monitoring and screening and/or as targets for the treatment of diseases and conditions in subjects, in particular autoimmune and infectious diseases. The identification of candidate biomarkers is predicated on identifying discriminating peptides present on a peptide array, which can distinguish samples from different subjects having different health conditions by the binding patterns of antibodies present in the samples.

公开(公告)号：US20200064345A1

公开(公告)日：2020-02-27

申请号：US16488078

申请日：2018-02-22

Applicant: HealthTell Inc.

Inventor： Kathryn Frances SYKES ,  Robert William GERWIEN ,  Jonathan Scott MELNICK ,  Michael William ROWE ,  Theodore Michael TARASOW

IPC: G01N33/569 ,  C12Q1/70 ,  G01N33/576

Abstract: The disclosed embodiments concern non-invasive methods, and apparatus, and systems for identifying infections. The methods are predicated on identifying discriminating peptides present on a peptide array, which are differentially bound by the different mixtures of antibodies present in samples from subjects consequent to an infection relative to binding of mixtures of antibodies present in reference subjects.

公开(公告)号：US20190113522A1

公开(公告)日：2019-04-18

申请号：US16090549

申请日：2017-03-31

Applicant: HealthTell Inc.

Inventor： Matthew GREVING ,  David SMITH ,  Gaurav SAINI

IPC: G01N33/68 ,  B01J19/00 ,  C40B50/18 ,  C40B40/10

Abstract: Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

公开(公告)号：US20190002410A1

公开(公告)日：2019-01-03

申请号：US16024171

申请日：2018-06-29

Applicant: HealthTell Inc.

Inventor： Robert KUIMELIS ,  Gaurav SAINI ,  David SMITH ,  Tommy ARMSBY

IPC: C07D233/02 ,  G03F9/00 ,  C07F7/18 ,  C07C233/13

Abstract: Provided herein are molecules and salts thereof, arrays containing molecules and salts thereof, solid supports containing molecules and salts thereof, kits containing molecules or salts thereof, and methods of determining alignment of photolithographic masks comprising molecules or salts thereof.