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公开(公告)号：US20210076931A1
公开(公告)日：2021-03-18
申请号：US16499386
申请日：2018-03-29
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Pierre POUGET , Pierre DAYE , Jean LORENCEAU
摘要： The invention relates to the evaluation of the perception of colors by mammals with a view to obtaining a characteristic biomarker of each tested subject. It takes advantage of the slow pupillary oscillatory response to generate an objective neurological signature of this perception of colors. A method based on pupil frequency tagging is used at a tagging frequency Ftag adapted to the pupil response speed. A dynamic two-color stimulus is displayed, this stimulus comprising a two-color pattern the colors of which are inverted at the frequency Ftag, one of the colors gradually varying in a range of possible values. From the pupillary response, a signal representative of the oscillation power of the pupil is generated. The minimum of this signal corresponds to the relative iso-luminance of the tested pair of colors.
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公开(公告)号：US11464407B2
公开(公告)日：2022-10-11
申请号：US16499782
申请日：2018-03-29
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Pierre Pouget , Alexis Genin
摘要： A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.
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3.发明公开公开(公告)号：US20230151439A1
公开(公告)日：2023-05-18
申请号：US17606554
申请日：2020-05-07
申请人： INSTITUT PASTEUR , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , INSERM (Institut National de la Sante et de la Recherche Medicale) , SORBONNE UNIVERSITE , INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE - ICM , ECOLE NATIONALE VETERINAIRE DE MAISONS ALFORT , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12Q1/6841
摘要： The invention relates to methods of diagnosis or detection of Moissiacense virus, a novel orthobunyavirus causing human encephalitis, comprising determining the presence of at least one nucleic acid or protein of said virus or antibodies thereto, in a biological sample. The invention also relates to the various diagnostic agents derived from the viral nucleic acids or proteins, in articular nucleic acid primers and probes, antigens and antibodies, and their use for the diagnosis of Moissiacense virus infection and associated disease, in particular encephalitis. The invention further relates to antigens derived from the viral proteins as vaccine for the prevention of Moissiacense virus infection and associated disease, in particular encephalitis.
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公开(公告)号：US11229356B2
公开(公告)日：2022-01-25
申请号：US16499386
申请日：2018-03-29
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Pierre Pouget , Pierre Daye , Jean Lorenceau
摘要： Evaluation of the perception of colors by mammals with a view to obtaining a characteristic biomarker of each tested subject takes advantage of the slow pupillary oscillatory response to generate an objective neurological signature of this perception of colors. A method based on pupil frequency tagging is used at a tagging frequency Ftag adapted to the pupil response speed. A dynamic two-color stimulus is displayed, this stimulus comprising a two-color pattern the colors of which are inverted at the frequency Ftag, one of the colors gradually varying in a range of possible values. From the pupillary response, a signal representative of the oscillation power of the pupil is generated. The minimum of this signal corresponds to the relative iso-luminance of the tested pair of colors.
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5.发明申请公开(公告)号：US20200037870A1
公开(公告)日：2020-02-06
申请号：US16499782
申请日：2018-03-29
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Pierre Pouget , Alexis Genin
摘要： A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.
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6.发明公开公开(公告)号：US20240023879A1
公开(公告)日：2024-01-25
申请号：US18256800
申请日：2021-12-10
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , SORBONNE UNIVERSITE , INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE – ICM , ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
发明人： Mario CHAVEZ , Louis COUSYN , Vincent NAVARRO
CPC分类号： A61B5/4094 , A61B5/7267 , A61B5/746 , G16H50/20
摘要： The invention relates to a method for training a model for predicting occurrence of an epileptic seizure, the method comprising performing a supervised training over a training dataset of a nonlinear binary classification model configured to receive as input the evaluation, by a patient, of the intensity of each prodromal symptom among a predefined set of prodromal symptoms, and to output a classification of said patient belonging either to a pre-ictal or inter-ictal state, and the training dataset comprises data inputs obtained from a plurality of epileptic patients, each data input comprising an evaluation, by a patient, of the intensity of each of the predefined set of prodromal symptoms, each data input being further associated to an indication of said patient belonging to a pre-ictal or inter-ictal state at the time of the evaluation. The invention also relates to a prediction model obtained accordingly, and a computing device for implementing said prediction model.
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公开(公告)号：US11143729B2
公开(公告)日：2021-10-12
申请号：US16757035
申请日：2018-10-15
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Mathieu Santin
IPC分类号： G01R33/561 , G01R33/56 , G01R33/565
摘要： The present invention improves the quality of the magnitude and phase images produced in medical imaging, in particular in the case of multi-antenna MRI. The invention proposes to generate (28) such an image (I) by summing the complex image data (pj,{tilde over (p)}j) obtained from different antennas by weighting these data using only the diagonal elements (Rj,j) of an antenna noise covariance matrix or its inverse or pseudo-inverse matrix (Rj,j−1). A reference antenna (Ref) may be determined (24), so as to be able to replace (26), in each of these datum, a phase component specific to the acquisition antenna by a reference phase component. The reference antenna is preferably a virtual antenna formed by linear combination of the antennas of the MRI system. If significant improvements are obtained in the phase image resulting from the summation, a very clear gain is also surprisingly obtained in the magnitude image.
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公开(公告)号：US20210072334A1
公开(公告)日：2021-03-11
申请号：US16757035
申请日：2018-10-15
申请人： INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (AP-HP) , SORBONNE UNIVERSITE
发明人： Mathieu SANTIN
IPC分类号： G01R33/561 , G01R33/565 , G01R33/56
摘要： The present invention improves the quality of the magnitude and phase images produced in medical imaging, in particular in the case of multi-antenna MRI. The invention proposes to generate (28) such an image (I) by summing the complex image data (pi,{tilde over (p)}j) obtained from different antennas by weighting these data using only the diagonal elements (Rj,j) of an antenna noise covariance matrix or its inverse or pseudo-inverse matrix (Rj,j−1). A reference antenna (Ref) may be determined (24), so as to be able to replace (26), in each of these datum, a phase component specific to the acquisition antenna by a reference phase component. The reference antenna is preferably a virtual antenna formed by linear combination of the antennas of the MRI system. If significant improvements are obtained in the phase image resulting from the summation, a very clear gain is also surprisingly obtained in the magnitude image.
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