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1.发明申请Use of 2,5-dihydroxybenzenesulfonic compounds for the treatment of disorders based on an impairment of no production and/or of regulation of edhf function 审中-公开基于无生产损伤和/或调节edhf功能的2,5-二羟基苯磺酸化合物用于治疗疾病的用途公开(公告)号：US20070010581A1
公开(公告)日：2007-01-11
申请号：US10536780
申请日：2003-11-29
IPC分类号： A61K31/185
CPC分类号： A61K31/185
摘要： The present invention relates to the use of 2,5-dihydroxybenzenesulfonic compounds for the manufacture of medicament for the regulation of nitric oxide (NO) synthesis and/or the regulation of EDHF (Endothelium-derived-Hyperpolarizing-Factor) in the endothelium of humans or animals, whereby the medicament is administered in a daily dose of the 2,5-dihydroxybenzenesulfonic compounds of formula I of
摘要翻译： 本发明涉及2,5-二羟基苯磺酸化合物在制备用于调节人的内皮中的一氧化氮（NO）合成和/或调节EDHF（内皮衍生的超极化因子）的药物中的用途 或动物，其中药物以日剂量的式I的2,5-二羟基苯磺酸化合物<500mg施用。
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2.发明申请Use of 2,5-dihydroxybenzenesulfonic compounds for the treatment of disorders based on an impairment of no production and/or of regulation of edhf function 审中-公开基于无生产损伤和/或调节edhf功能的2,5-二羟基苯磺酸化合物用于治疗疾病的用途公开(公告)号：US20060135611A1
公开(公告)日：2006-06-22
申请号：US10536782
申请日：2003-11-29
IPC分类号： A61K31/185
CPC分类号： A61K31/185
摘要： The present invention relates to the use of 2,5-dihydroxybenzenesulfonic compounds for the manufacture of a medicament for the regulation of nitric oxide (NO) synthesis and/or the regulation of EDHF (Endothelium-Derived-Hyperpolarizing-Factor) in the endothelium of diabetic patients, whereby the medicament is administered in a daily dose of the 2,5-dihydroxybenzenesulfonic compounds of formula (I) of
摘要翻译： 本发明涉及2,5-二羟基苯磺酸化合物在制备用于调节一氧化氮（NO）合成和/或调节内皮中的EDHF（内皮衍生的超极化因子）的药物中的用途 糖尿病患者，其中药物以每日剂量的<500mg式（I）的2,5-二羟基苯磺酸化合物给药。
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3.发明申请USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF PSORIASIS 有权使用2,5-二羟基苯乙烯化合物和衍生物进行PSORIASIS的治疗公开(公告)号：US20110311528A1
公开(公告)日：2011-12-22
申请号：US13166569
申请日：2011-06-22
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/235 , A61K31/255 , A61K31/185 , A61K31/573 , A61P17/06 , A61K31/519 , A61K38/13 , A61K39/395 , A61K39/44 , A61K31/60 , A61K31/192 , A61K31/59
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防银屑病方面的用途。
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4.发明申请Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases 审中-公开使用2,5-二羟基苯衍生物治疗组织活动性疾病公开(公告)号：US20080114063A1
公开(公告)日：2008-05-15
申请号：US11839529
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Luis Ignacio Rivas Lopez , Francisco Javier Moreno Nuncio , Tomas Fernado Fernandez Jaen , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Luis Ignacio Rivas Lopez , Francisco Javier Moreno Nuncio , Tomas Fernado Fernandez Jaen , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/22 , A61K31/225 , A61K31/185
CPC分类号： A61K31/10 , A61K31/192 , A61K31/60 , A61K31/618 , Y02A50/409
摘要： The present invention relates to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of benign prostatic hyperplasia, Barrett's disease, asthma, skeletal muscle and tendon repair, Crohn's disease, ulcerative colitis and leishmaniasis.
摘要翻译： 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂化物，异构体或前体药物在治疗和/或预防任何选自以下的疾病中的用途：良性前列腺增生， 巴雷特氏病，哮喘，骨骼肌和腱修复，克罗恩病，溃疡性结肠炎和利什曼病。
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5.发明申请Active substance combination comprising a 2,5-dihydroxybenzenesulfonic compound and a potassium ion channel modulator 审中-公开包含2,5-二羟基苯磺酸化合物和钾离子通道调节剂的活性物质组合公开(公告)号：US20070032471A1
公开(公告)日：2007-02-08
申请号：US10566132
申请日：2004-07-29
申请人： Antoni Torrens Jover , Ines Alvarez Mathieu , Inigo Saenz De Tejada Gorman , Javier Angulo Frutos , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Ines Alvarez Mathieu , Inigo Saenz De Tejada Gorman , Javier Angulo Frutos , Helmut-Heinrich Buschmann
IPC分类号： A61K31/554 , A61K31/4184 , A61K31/185
CPC分类号： A61K9/2059 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/4858 , A61K9/4866 , A61K45/06
摘要： The present invention relates to an active substance combination comprising at least one 2,5-dihydroxybenzenesulfonic compound and at least one K+ channel modulator, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种2,5-二羟基苯磺酸化合物和至少一种K +通道调节剂的活性物质组合物，包含所述活性物质组合物的药物，包含所述活性物质组合的药物制剂和所述活性物质的用途 组合用于制造药物。
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公开(公告)号：US08815836B2
公开(公告)日：2014-08-26
申请号：US13209803
申请日：2011-08-15
申请人： Pedro Cueva Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cueva Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A01N37/36 , A01N45/00 , A61K31/56 , A01N41/02 , A61K31/255 , A01N37/10 , A61K31/235 , A01N37/02 , A61K31/22 , A61K31/60 , A61K31/10 , A61K31/618 , A61K31/192
CPC分类号： A61K31/185 , A61K8/368 , A61K8/466 , A61K31/10 , A61K31/192 , A61K31/222 , A61K31/225 , A61K31/60 , A61K31/618 , A61K45/06 , A61Q17/04 , A61Q19/08
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis.
摘要翻译： 本发明涉及由式（I）表示的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防性治疗特别是皮炎的用途。
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7.发明申请Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Rosacea 审中-公开使用2,5-二羟基苯化合物和衍生物治疗红斑痤疮公开(公告)号：US20080113947A1
公开(公告)日：2008-05-15
申请号：US11839515
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防酒渣肠炎的用途。
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8.发明申请Use of derivatives of 2, 5-dihydroxyb enzene-sulphonic acids in the elaboration of a medicinal product to enhance the effect of other drugs used for the treatment of erectile dysfunction 审中-公开在制备药物中使用2,5-二羟基苯磺酸衍生物以增强用于治疗勃起功能障碍的其他药物的作用公开(公告)号：US20070197543A1
公开(公告)日：2007-08-23
申请号：US11641269
申请日：2006-12-19
IPC分类号： A61K31/519 , A61K31/185
CPC分类号： A61K45/06 , A61K31/185 , A61K2300/00
摘要： The present invention refers to the use of derivatives of 2,5-dihidroxybenzenosulphonic acids of general formula (I), to develop medicinal products of therapeutic value to enhance the effects of phosphodiesterase-5 including sildenaphyl, vardenaphyl and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerine, nitroprussiate, nitrosothioles and nicorandyl, of the compounds that increase the level of cyclic GMP in the penile tissue and of other compounds used to facilitate penile erection in man.
摘要翻译： 本发明涉及使用通式（I）的2,5-二羟基苯磺酸的衍生物来开发具有治疗价值的药物以增强磷酸二酯酶-5（包括西地那非，伐地那啶和IC-351）对阿扑吗啡的作用， 的一氧化氮供体包括硝酸甘油，硝基甘油，硝普钠，亚硝基硫醇和尼可兰基，增加阴茎组织中环状GMP水平的化合物和用于促进人类阴茎勃起的其他化合物。
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