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公开(公告)号：US09198886B2
公开(公告)日：2015-12-01
申请号：US12986674
申请日：2011-01-07
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
CPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
摘要： The present invention relates to the use of a compound of Formula (IIV) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of macular degeneration, corneal neovascularization or angiogenesis, iris neovascularization or angiogenesis, retinal neovascularization or angiogenesis, diabetic proliferative retinopathy and non-diabetic proliferative retinopathy.
摘要翻译： 本发明涉及式（IIV）化合物或其药学上可接受的盐或溶剂化物，异构体或前体药物在制备用于治疗和/或预防任何选自下组的疾病的药物中的用途： 黄斑变性，角膜新生血管形成或血管生成，虹膜新生血管形成或血管生成，视网膜新生血管形成或血管生成，糖尿病性增生性视网膜病变和非糖尿病性增生性视网膜病变。
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2.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US08889737B2
公开(公告)日：2014-11-18
申请号：US13326778
申请日：2011-12-15
申请人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/222
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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3.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ 有权2,5-二羟基苯化合物及其衍生物用于治疗器官的血液恶化和癌症公开(公告)号：US08541467B2
公开(公告)日：2013-09-24
申请号：US11839525
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A01N37/02 , A01N41/10 , A01N31/08 , A61K31/22 , A61K31/225
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodisplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ.
摘要翻译： 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂合物，异构体或前体药物在治疗和/或预防血液恶化症中的用途，包括骨髓增生异常综合征（MDS）和用于改善功效 的化疗，放射治疗和/或癌症免疫治疗。 此外，它涉及式（I“）化合物用于治疗和/或预防器官癌症的用途。
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公开(公告)号：US20120015912A1
公开(公告)日：2012-01-19
申请号：US12986674
申请日：2011-01-07
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Maria Luisa Krauel , Javier Angulo Frutos , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/185 , C07C65/05 , A61K31/235 , A61K31/192 , A61K31/56 , A61P31/00 , A61P37/02 , A61P37/06 , A61P35/00 , A61P29/00 , A61P39/06 , A61P33/00 , A61P23/00 , A61P27/02 , C07C309/42
CPC分类号： A61K31/185 , A61K31/192 , A61K31/235 , A61K31/56 , A61K45/06
摘要： The present invention relates to the use of a compound of Formula (IIV) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of macular degeneration, corneal neovascularization or angiogenesis, iris neovascularization or angiogenesis, retinal neovascularization or angiogenesis, diabetic proliferative retinopathy and non-diabetic proliferative retinopathy.
摘要翻译： 本发明涉及式（IIV）化合物或其药学上可接受的盐或溶剂化物，异构体或前体药物在制备用于治疗和/或预防任何选自下组的疾病的药物中的用途： 黄斑变性，角膜新生血管形成或血管生成，虹膜新生血管形成或血管生成，视网膜新生血管形成或血管生成，糖尿病性增生性视网膜病变和非糖尿病性增生性视网膜病变。
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5.发明申请Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Skin Cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US20080114060A1
公开(公告)日：2008-05-15
申请号：US11839522
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Vaverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Vaverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isoomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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6.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US08101660B2
公开(公告)日：2012-01-24
申请号：US11839522
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/222 , A61K31/12 , A61K31/10
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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7.发明申请USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF PSORIASIS 有权使用2,5-二羟基苯乙烯化合物和衍生物进行PSORIASIS的治疗公开(公告)号：US20110311528A1
公开(公告)日：2011-12-22
申请号：US13166569
申请日：2011-06-22
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/235 , A61K31/255 , A61K31/185 , A61K31/573 , A61P17/06 , A61K31/519 , A61K38/13 , A61K39/395 , A61K39/44 , A61K31/60 , A61K31/192 , A61K31/59
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防银屑病方面的用途。
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8.发明申请Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases 审中-公开使用2,5-二羟基苯衍生物治疗组织活动性疾病公开(公告)号：US20080114063A1
公开(公告)日：2008-05-15
申请号：US11839529
申请日：2007-08-15
申请人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Luis Ignacio Rivas Lopez , Francisco Javier Moreno Nuncio , Tomas Fernado Fernandez Jaen , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
发明人： Pedro Cuevas Sanchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Luis Ignacio Rivas Lopez , Francisco Javier Moreno Nuncio , Tomas Fernado Fernandez Jaen , Rosa Maria Lozano Puerto , Antonio Romero Garrido , Serafin Valverde Lopez
IPC分类号： A61K31/22 , A61K31/225 , A61K31/185
CPC分类号： A61K31/10 , A61K31/192 , A61K31/60 , A61K31/618 , Y02A50/409
摘要： The present invention relates to the use of a compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of any of the diseases selected from the group consisting of benign prostatic hyperplasia, Barrett's disease, asthma, skeletal muscle and tendon repair, Crohn's disease, ulcerative colitis and leishmaniasis.
摘要翻译： 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂化物，异构体或前体药物在治疗和/或预防任何选自以下的疾病中的用途：良性前列腺增生， 巴雷特氏病，哮喘，骨骼肌和腱修复，克罗恩病，溃疡性结肠炎和利什曼病。
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9.发明申请Active substance combination comprising a 2,5-dihydroxybenzenesulfonic compound and a potassium ion channel modulator 审中-公开包含2,5-二羟基苯磺酸化合物和钾离子通道调节剂的活性物质组合公开(公告)号：US20070032471A1
公开(公告)日：2007-02-08
申请号：US10566132
申请日：2004-07-29
申请人： Antoni Torrens Jover , Ines Alvarez Mathieu , Inigo Saenz De Tejada Gorman , Javier Angulo Frutos , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Ines Alvarez Mathieu , Inigo Saenz De Tejada Gorman , Javier Angulo Frutos , Helmut-Heinrich Buschmann
IPC分类号： A61K31/554 , A61K31/4184 , A61K31/185
CPC分类号： A61K9/2059 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/4858 , A61K9/4866 , A61K45/06
摘要： The present invention relates to an active substance combination comprising at least one 2,5-dihydroxybenzenesulfonic compound and at least one K+ channel modulator, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种2,5-二羟基苯磺酸化合物和至少一种K +通道调节剂的活性物质组合物，包含所述活性物质组合物的药物，包含所述活性物质组合的药物制剂和所述活性物质的用途 组合用于制造药物。
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10.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of psoriasis 有权使用2,5-二羟基苯化合物及其衍生物治疗牛皮癣公开(公告)号：US08530454B2
公开(公告)日：2013-09-10
申请号：US13166569
申请日：2011-06-22
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Javier Angulo Frutos , Serafin Valverde Lopez , Atonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Atonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/185 , A61P17/12 , A61P17/06
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, psoriasis.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防银屑病方面的用途。
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