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公开(公告)号:US07211560B2
公开(公告)日:2007-05-01
申请号:US10747580
申请日:2003-12-29
申请人: Douglas L. Looker , Izydor Z. Apostol , Eric A. Brucker , Michael P. Doyle , David L. Foster , Christopher B. Glascock , James C. Hartman , Geoffrey F. Lee , Douglas D. Lemon , Edwin G. Moore , Jane P. Richards , Michael R. Schick , Stephen P. Trimble , David Pereira , Ton-That Hai , Kenneth E. Burhop
发明人: Douglas L. Looker , Izydor Z. Apostol , Eric A. Brucker , Michael P. Doyle , David L. Foster , Christopher B. Glascock , James C. Hartman , Geoffrey F. Lee , Douglas D. Lemon , Edwin G. Moore , Jane P. Richards , Michael R. Schick , Stephen P. Trimble , David Pereira , Ton-That Hai , Kenneth E. Burhop
IPC分类号: A61K35/14
CPC分类号: C07K14/805 , A61K38/00
摘要: The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.
摘要翻译: 本发明涉及新型血红蛋白组合物,特别是新型重组突变体血红蛋白组合物,其消除或显着减少1)心脏病变的产生,2)胃肠道不适,3)加压作用,和4)与施用细胞外血红蛋白相关的内毒素超敏反应 各种治疗应用中的组合物。 描述的应用包括贫血,头部损伤,出血或血容量不足,局部缺血,恶病质,镰状细胞危象和中风的治疗。 加强癌症治疗; 刺激造血; 改善身体损伤组织的修复; 减轻心源性休克; 和休克复苏。
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公开(公告)号:US6140071A
公开(公告)日:2000-10-31
申请号:US188374
申请日:1994-01-27
CPC分类号: C07K14/805 , C12N15/102 , A61K38/00
摘要: This invention relates to proteins with N-terminal modifications in their amino acid sequence that reduce or eliminate the methylation of the N-terminal methionine that occurs when such proteins are produced in bacteria such as E. coli.
摘要翻译: 本发明涉及在其氨基酸序列中具有N端修饰的蛋白质,其减少或消除当在诸如大肠杆菌的细菌中产生这种蛋白质时发生的N-末端甲硫氨酸的甲基化。
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公开(公告)号:US06670323B1
公开(公告)日:2003-12-30
申请号:US09709914
申请日:2000-11-10
申请人: Douglas L. Looker , Izydor Z. Apostol , Eric A. Brucker , Michael P. Doyle , David L. Foster , Christopher B. Glascock , James C. Hartman , Geoffrey F. Lee , Douglas D. Lemon , Edwin G. Moore , Jane P. Richards , Michael R. Schick , Stephen P. Trimble , David Pereira , Ton-That Hai , Kenneth E. Burhop
发明人: Douglas L. Looker , Izydor Z. Apostol , Eric A. Brucker , Michael P. Doyle , David L. Foster , Christopher B. Glascock , James C. Hartman , Geoffrey F. Lee , Douglas D. Lemon , Edwin G. Moore , Jane P. Richards , Michael R. Schick , Stephen P. Trimble , David Pereira , Ton-That Hai , Kenneth E. Burhop
IPC分类号: C07K14805
CPC分类号: C07K14/805 , A61K38/00
摘要: The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.
摘要翻译: 本发明涉及新型血红蛋白组合物,特别是新型重组突变体血红蛋白组合物,其消除或显着减少1)心脏病变的产生,2)胃肠道不适,3)加压作用,和4)与施用细胞外血红蛋白相关的内毒素超敏反应 各种治疗应用中的组合物。 描述的应用包括贫血,头部损伤,出血或血容量不足,局部缺血,恶病质,镰状细胞危象和中风的治疗。 加强癌症治疗; 刺激造血; 改善身体损伤组织的修复; 减轻心源性休克; 和休克复苏。
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公开(公告)号:US5811264A
公开(公告)日:1998-09-22
申请号:US609271
申请日:1996-02-29
CPC分类号: C07K14/805 , C12N15/102 , A61K38/00
摘要: Mutated protein having a sequence with a non-proline amino acid replacement for a proline at amino acid position 4. The mutated protein is not methylated on its N-terminus when expressed in bacteria. The mutated protein is a mutation of a methylated protein that is at least partially methylated on its N-terminus when expressed in bacteria.
摘要翻译: 在氨基酸位置4具有脯氨酸取代的非脯氨酸氨基酸序列的突变蛋白质。当在细菌中表达时,突变的蛋白质在其N-末端不被甲基化。 突变的蛋白质是当在细菌中表达时在其N-末端至少部分甲基化的甲基化蛋白质的突变。
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