公开(公告)号：US20110123439A1

公开(公告)日：2011-05-26

申请号：US12991503

申请日：2009-05-08

申请人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

发明人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

IPC分类号： A61K51/12

CPC分类号： A61K49/186 ,  A61K49/0002 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/1863 ,  A61K49/1869 ,  A61K49/1875 ,  A61K51/1255

摘要： The present invention relates a dual-modality PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a hybrid nanoparticle comprising: (a) a magnetic signal generating core; (b) a water-soluble multi-functional ligand coated on the signal generating core; and (c) a positron emitting factor linked to the water-soluble multi-functional ligand. The contrast agent of the present invention is the dual-modality contrast agent enabling to perform PET and MR imaging and can effectively obtain images having the merits of PET (excellent sensitivity and high temporal resolution) and MR (high spatial resolution and anatomical information) imaging. The contrast agent of the present invention is very useful for non-invasive and highly sensitive real-time fault-free imaging of various biological events such as cell migration, diagnosis of various diseases (e.g., cancer diagnosis) and drug delivery.

摘要翻译： 本发明涉及双重模式PET（正电子发射断层摄影）/ MRI（磁共振成像）造影剂，混合纳米颗粒，其包括：（a）磁信号产生芯; （b）涂覆在信号产生芯上的水溶性多官能配体; 和（c）与水溶性多官能配体连接的正电子发射因子。 本发明的造影剂是能够进行PET和MR成像的双重模式对比剂，并且可以有效地获得具有PET优点（优异的灵敏度和高时间分辨率）和MR（高空间分辨率和解剖信息）成像的图像 。 本发明的造影剂对于诸如细胞迁移，各种疾病的诊断（例如癌症诊断）和药物递送的各种生物事件的非侵入性和高度灵敏度的实时无故障成像非常有用。

公开(公告)号：US09079867B2

公开(公告)日：2015-07-14

申请号：US13521177

申请日：2011-02-14

申请人： Jeongsoo Yoo ,  Darpan Navinchandra Pandya

发明人： Jeongsoo Yoo ,  Darpan Navinchandra Pandya

IPC分类号： C07D257/02 ,  C07K7/64 ,  A61P35/00 ,  A61K31/395 ,  A61K49/00 ,  A61K31/555 ,  C07F1/08 ,  C07K16/18 ,  A61K51/08 ,  A61K51/10

CPC分类号： C07D257/02 ,  A61K51/082 ,  A61K51/088 ,  A61K51/1051 ,  A61K51/1093

摘要： According to the present invention, a novel polyazamacrocyclic compound which is used as a bifunctional chelating agent (BFC) can be synthesized selectively and in high yield. The novel polyazamacrocyclic compound synthesized by this method chelates with metals and thus can be conjugated with bioactive molecules such as peptides, and can be used in the diagnosis and treatment of medical conditions.

摘要翻译： 根据本发明，可以选择性且高收率地合成用作双功能螯合剂（BFC）的新型多氮杂环化合物。 通过该方法合成的新型多氮杂环化合物与金属螯合，因此可与肽等生物活性分子结合，可用于医疗条件的诊断和治疗。

公开(公告)号：US20130004423A1

公开(公告)日：2013-01-03

申请号：US13521177

申请日：2011-02-14

申请人： Jeongsoo Yoo ,  Darpan Navinchandra Pandya

发明人： Jeongsoo Yoo ,  Darpan Navinchandra Pandya

IPC分类号： C07D257/02 ,  C07K7/64 ,  A61P35/00 ,  A61K31/395 ,  A61K49/00 ,  A61K31/555 ,  C07F1/08 ,  C07K16/18

CPC分类号： C07D257/02 ,  A61K51/082 ,  A61K51/088 ,  A61K51/1051 ,  A61K51/1093

摘要： According to the present invention, a novel polyazamacrocyclic compound which is used as a bifunctional chelating agent (BFC) can be synthesized selectively and in high yield. The novel polyazamacrocyclic compound synthesized by this method chelates with metals and thus can be conjugated with bioactive molecules such as peptides, and can be used in the diagnosis and treatment of medical conditions.

摘要翻译： 根据本发明，可以选择性且高收率地合成用作双功能螯合剂（BFC）的新型多氮杂环化合物。 通过该方法合成的新型多氮杂环化合物与金属螯合，因此可与肽等生物活性分子结合，可用于医疗条件的诊断和治疗。