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公开(公告)号：US09527925B2
公开(公告)日：2016-12-27
申请号：US13433359
申请日：2012-03-29
CPC分类号： C07K16/468 , C07K16/18 , C07K16/22 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Bispecific binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要翻译： 结合VEGF和Ang2两者的双特异性结合分子，优选以免疫球蛋白单可变结构域（如VHH和结构域抗体）的形式，含有它们的药物组合物及其在治疗与VEGF-和/或Ang2介导的疾病相关的疾病中的用途 公开了对血管发生的作用。 此外，还描述了编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20130259859A1
公开(公告)日：2013-10-03
申请号：US13852402
申请日：2013-03-28
申请人： Rene Georg OTT , Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Marie-Ange BUYSE , Erik DEPLA , Pascal MERCHIERS , Frederik STEVENAERT
发明人： Rene Georg OTT , Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Marie-Ange BUYSE , Erik DEPLA , Pascal MERCHIERS , Frederik STEVENAERT
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
摘要： Ang2-binding molecules, preferably Ang2-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with Ang2-mediated effects on angiogenesis. Nucleic acids encoding Ang2-binding molecules, host cells and methods for preparing same.
摘要翻译： Ang2结合分子，优选Ang2结合免疫球蛋白单可变结构域如VHH和结构域抗体，含有它们的药物组合物及其在治疗与Ang2介导的对血管发生的作用相关的疾病中的用途。 编码Ang2-结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20110195494A1
公开(公告)日：2011-08-11
申请号：US12894947
申请日：2010-09-30
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/22 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： DII4-binding molecules, preferably DII4-binding immunoglobulin single variable domains like VHHs and VHs, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with DII4-mediated effects on angiogenesis. Bispecific DII4-binding molecules that also bind to VEGF-A. Nucleic acids encoding DII4-binding molecules, host cells and methods for preparing same.
摘要翻译： DII4结合分子，优选DII4结合免疫球蛋白单可变结构域如VHH和VH，含有它们的药物组合物及其在治疗与DII4介导的对血管发生的作用相关的疾病中的用途。 也与VEGF-A结合的双特异性DII4结合分子。 编码DII4结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20130078247A1
公开(公告)日：2013-03-28
申请号：US13433354
申请日：2012-03-29
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/22 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Bispecific binding molecules binding to both DII4 and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with DII4- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要翻译： 结合DII4和Ang2的双特异性结合分子，优选以免疫球蛋白单可变结构域（如VHH和结构域抗体）的形式，含有它们的药物组合物及其在治疗与DII4和/或Ang2介导的疾病相关的疾病中的用途 公开了对血管发生的作用。 此外，还描述了编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20120225081A1
公开(公告)日：2012-09-06
申请号：US13223563
申请日：2011-09-01
申请人： Andreas GSCHWIND , Eric BORGES , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS
发明人： Andreas GSCHWIND , Eric BORGES , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS
IPC分类号： A61K39/395 , C12N15/13 , A61P35/00 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C07K16/22 , A61P27/02
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： VEGF-binding molecules, preferably VEGF-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF-mediated effects on angiogenesis. Nucleic acids encoding VEGF-binding molecules, host cells and methods for preparing same.
摘要翻译： VEGF结合分子，优选VEGF结合免疫球蛋白单可变域如VHH和结构域抗体，含有它们的药物组合物及其在治疗与VEGF介导的对血管发生的作用相关的疾病中的用途。 编码VEGF结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20140120095A1
公开(公告)日：2014-05-01
申请号：US13848826
申请日：2013-03-22
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和DII4结合组分。 含有它们的药物组合物及其在治疗与VEGF和DII4介导的血管生成作用相关的疾病中的用途。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20130078248A1
公开(公告)日：2013-03-28
申请号：US13433359
申请日：2012-03-29
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/22 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/62 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Bispecific binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要翻译： 结合VEGF和Ang2两者的双特异性结合分子，优选以免疫球蛋白单可变结构域（如VHH和结构域抗体）的形式，含有它们的药物组合物及其在治疗与VEGF-和/或Ang2介导的疾病相关的疾病中的用途 公开了对血管发生的作用。 此外，还描述了编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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公开(公告)号：US20110172398A1
公开(公告)日：2011-07-14
申请号：US12894989
申请日：2010-09-30
申请人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
发明人： Eric BORGES , Andreas GSCHWIND , Joachim BOUCNEAU , Evelyn DE TAVERNIER , Joost KOLKMAN , Pascal MERCHIERS , Diane VAN HOORICK
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.
摘要翻译： 双特异性结合分子，特别是免疫球蛋白单可变结构域，例如VHH和结构域抗体，其在一个分子中包含VEGF结合组分和Dll4结合组分。 含有该组合物的药物组合物及其用于治疗与VEGF和Dll4介导的血管生成作用相关的疾病。 编码双特异性结合分子的核酸，宿主细胞及其制备方法。
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