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1.发明申请PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开抑制β-分泌酶活性的吡咯烷酮化合物及其使用方法公开(公告)号：US20120295894A1
公开(公告)日：2012-11-22
申请号：US13309181
申请日：2011-12-01
申请人： Geoffrey M. BILCER , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
发明人： Geoffrey M. BILCER , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
IPC分类号： A61K31/427 , C07D417/12 , C07D413/12 , A61K31/422 , C07D413/14 , C12N9/99 , A61K31/4439 , A61K31/5377 , A61K31/454 , A61K31/541 , A61P25/28 , C07D417/14 , A61K31/497
CPC分类号： C07D417/14 , A61K31/16 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译： 本文描述的是新型β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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2.发明授权(3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating 失效（3-羟基-4-氨基 - 丁-2-基）-3-（2-噻唑-2-基 - 吡咯烷-1-羰基）苯甲酰胺衍生物和相关化合物作为β-分泌酶抑制剂，用于治疗公开(公告)号：US08299267B2
公开(公告)日：2012-10-30
申请号：US12677748
申请日：2008-09-24
申请人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
发明人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
IPC分类号： C07D417/14 , C07D211/68 , C07D417/00 , C07D413/00 , C07D277/30 , C07D277/28 , C07D263/30 , A61K31/44 , A61K31/445 , A61K31/42 , A61K31/425
CPC分类号： C07D417/14 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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3.发明申请PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开抑制β-分泌酶活性的吡咯烷酮化合物及其使用方法公开(公告)号：US20130102593A1
公开(公告)日：2013-04-25
申请号：US13123101
申请日：2009-10-09
申请人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
发明人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
IPC分类号： C07D417/14 , C07D417/12
CPC分类号： C07D417/14 , A61K31/16 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译： 本文描述的是新型β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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公开(公告)号：US20100286145A1
公开(公告)日：2010-11-11
申请号：US12670105
申请日：2008-07-25
申请人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
发明人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
IPC分类号： A61K31/5377 , C12N9/99 , A61K31/4965 , A61K31/444 , A61K31/4439 , A61K31/427 , C07D417/12 , C07D417/14 , A61P25/28
CPC分类号： C07D277/28 , C07B2200/07 , C07C233/78 , C07C235/50 , C07C235/84 , C07C239/18 , C07C309/66 , C07C311/08 , C07D213/40 , C07D231/12 , C07D239/26 , C07D241/12 , C07D263/32 , C07D307/28 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07F9/6539
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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5.发明申请公开(公告)号：US20120214802A1
公开(公告)日：2012-08-23
申请号：US13259091
申请日：2009-10-09
申请人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
发明人： Geoffrey M. Bilcer , Thippeswamy Devasamudram , Sudha V. Ankala , John C. Lilly , Chunfeng Liu , Hui Lei , Arun K. Ghosh , Makoto Inoue
IPC分类号： A61K31/427 , A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/40 , C07D417/14 , C07D413/12 , C07D207/16 , C07D207/09 , C07D417/12 , C07D413/14 , A61P25/28 , C12N9/99
CPC分类号： A61K31/16 , A61K31/195 , A61K31/40 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
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6.发明申请(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING 失效（3-羟基-4-氨基 - 丁-2-炔基）-3-（2-噻唑-2-基） - 吡咯烷-1-羰基]苯甲酰胺衍生物及相关化合物作为用于治疗的β-分泌酶抑制剂公开(公告)号：US20100286170A1
公开(公告)日：2010-11-11
申请号：US12677748
申请日：2008-09-24
申请人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
发明人： Arun K. Ghosh , Chunfeng Liu , Thippeswamy Devasamudram , Hui Lei , Lisa M. Swanson , Sudha V. Ankala , John C. Lilly , Geoffrey M. Bilcer
IPC分类号： A61K31/497 , C07D417/14 , C07D417/04 , C07D401/10 , C07D207/08 , C07D413/04 , C07D413/14 , C12N9/99 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/427 , A61K31/40 , A61K31/422 , A61P25/28
CPC分类号： C07D417/14 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
摘要翻译： 本发明提供新颖的β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。
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