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公开(公告)号：US07378414B2
公开(公告)日：2008-05-27
申请号：US10925072
申请日：2004-08-24
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D285/26 , A61K31/549
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US07538105B2
公开(公告)日：2009-05-26
申请号：US12098024
申请日：2008-04-04
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US20080193413A1
公开(公告)日：2008-08-14
申请号：US12098024
申请日：2008-04-04
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： A61K31/542 , C07D495/04 , C12N7/06 , A61K38/21 , A61P31/12
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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