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公开(公告)号：US07378414B2
公开(公告)日：2008-05-27
申请号：US10925072
申请日：2004-08-24
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D285/26 , A61K31/549
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US07538105B2
公开(公告)日：2009-05-26
申请号：US12098024
申请日：2008-04-04
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US20080193413A1
公开(公告)日：2008-08-14
申请号：US12098024
申请日：2008-04-04
申请人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
发明人： Douglas K. Hutchinson , John R. Bellettini , David A. Betebenner , Richard D. Bishop , Thomas B. Borchardt , Todd D. Bosse , Russell D. Cink , Charles A. Flentge , Bradley D. Gates , Brian E. Green , Mira M. Hinman , Peggy P. Huang , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , M. Robert Leanna , Dachun Liu , Darold L. Madigan , Keith F. McDaniel , John T. Randolph , Todd W. Rockway , Teresa A. Rosenberg , Kent D. Stewart , Vincent S. Stoll , Rolf Wagner , Ming C. Yeung
IPC分类号： A61K31/542 , C07D495/04 , C12N7/06 , A61K38/21 , A61P31/12
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US07902203B2
公开(公告)日：2011-03-08
申请号：US10699513
申请日：2003-10-31
申请人： John K. Pratt , David A. Betebenner , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Keith F. McDaniel , Clarence J. Maring , Vincent S. Stoll , Rong Zhang , Hui-Ju Chen , William J. Flosi , Larry L. Klein , Allan C. Krueger , Dachun Liu , Darold L. Madigan , Laura M. Maymon , Todd W. Rockway , Kent D. Stewart , Ming C. Yeung , Qinghua Xie
发明人： John K. Pratt , David A. Betebenner , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Keith F. McDaniel , Clarence J. Maring , Vincent S. Stoll , Rong Zhang , Hui-Ju Chen , William J. Flosi , Larry L. Klein , Allan C. Krueger , Dachun Liu , Darold L. Madigan , Laura M. Maymon , Todd W. Rockway , Kent D. Stewart , Ming C. Yeung , Qinghua Xie
IPC分类号： A01N43/54 , A01N43/90 , C07D285/00 , C07D285/22
CPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
摘要翻译： 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供了抑制丙型肝炎病毒（HCV）聚合酶，抑制HCV病毒复制的方法以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。
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公开(公告)号：US08497275B2
公开(公告)日：2013-07-30
申请号：US12492518
申请日：2009-06-26
申请人： Brian E. Green , David D. Anderson , Todd D. Bosse , Curt S. Cooper , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , Dachun Liu , Keith F. McDaniel , Christopher E. Motter , John K. Pratt , Todd W. Rockway , Teresa A. Rosenberg , Ming C. Yeung , Hui-Ju Chen , Jason P. Shanley
发明人： Brian E. Green , David D. Anderson , Todd D. Bosse , Curt S. Cooper , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , Dachun Liu , Keith F. McDaniel , Christopher E. Motter , John K. Pratt , Todd W. Rockway , Teresa A. Rosenberg , Ming C. Yeung , Hui-Ju Chen , Jason P. Shanley
IPC分类号： A61K31/4965 , A61K31/40 , A61K38/00 , A61K38/05
CPC分类号： C07D403/12 , C07D207/16 , C07D241/24 , C07D403/14 , C07D409/14 , C07K7/02
摘要： This invention relates to: (a) compounds of formula I and salts thereof that, inter alia, are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）式I化合物及其盐，其特别可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。
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公开(公告)号：US20100029686A1
公开(公告)日：2010-02-04
申请号：US12492518
申请日：2009-06-26
申请人： Brian E. Green , David D. Anderson , Todd D. Bosse , Curt S. Cooper , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , Dachun Liu , Keith F. McDaniel , Christopher E. Motter , John K. Pratt , Todd W. Rockway , Teresa A. Rosenberg , Ming C. Yeung , Hui-Ju Chen , Jason P. Shanley
发明人： Brian E. Green , David D. Anderson , Todd D. Bosse , Curt S. Cooper , Larry L. Klein , Allan C. Krueger , Daniel P. Larson , Dachun Liu , Keith F. McDaniel , Christopher E. Motter , John K. Pratt , Todd W. Rockway , Teresa A. Rosenberg , Ming C. Yeung , Hui-Ju Chen , Jason P. Shanley
IPC分类号： A61K31/497 , C07D241/12 , A61K31/4965 , C07D403/12 , C07D207/00 , A61K31/40 , A61P31/00
CPC分类号： C07D403/12 , C07D207/16 , C07D241/24 , C07D403/14 , C07D409/14 , C07K7/02
摘要： This invention relates to: (a) compounds of formula I and salts thereof that, inter alia, are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）式I化合物及其盐，其特别可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。
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公开(公告)号：US08501238B2
公开(公告)日：2013-08-06
申请号：US13451889
申请日：2012-04-20
申请人： Charles A. Flentge , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G. Z. Zhang
发明人： Charles A. Flentge , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G. Z. Zhang
IPC分类号： A61K9/14 , A61K31/505 , C07D239/02 , C07D401/00
CPC分类号： C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号：US20120244119A1
公开(公告)日：2012-09-27
申请号：US13451889
申请日：2012-04-20
申请人： Charles A. Flentge , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G.Z. Zhang
发明人： Charles A. Flentge , Douglas K. Hutchinson , David A. Betebenner , David A. DeGoey , Pamela L. Donner , Warren M. Kati , Allan C. Krueger , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , Christopher E. Motter , John K. Pratt , John T. Randolph , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , Xiaochun Lou , Geoff G.Z. Zhang
IPC分类号： C07D239/54 , A61K38/21 , A61P31/14 , A61K31/513
CPC分类号： C07D239/54 , A61K31/513 , A61K45/06 , C07D239/22 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K2300/00
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译： 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。
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公开(公告)号：US07910595B2
公开(公告)日：2011-03-22
申请号：US11613810
申请日：2006-12-20
申请人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号： C07D471/04 , A01N31/519 , A61P31/12
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译： 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US07915411B2
公开(公告)日：2011-03-29
申请号：US11613825
申请日：2006-12-20
申请人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号： C07D471/04 , A61P1/16
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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